Mrgprx2 MAS-related GPR, member X2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrgprx2provided by MGI
Official Full Name: MAS-related GPR, member X2provided by MGI
Primary source: MGI:MGI:3588270
See related: Ensembl:ENSMUSG00000074109 AllianceGenome:MGI:3588270
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MrgB10; Mrgprb10; G370024M05Rik
Summary: Enables mast cell secretagogue receptor activity. Involved in mast cell activation. Predicted to be active in plasma membrane. Orthologous to several human genes including MRGPRX2 (MAS related GPR family member X2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 7 B4; 7 31.11 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (48128367..48149018, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (48478619..48499270, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
Title: miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain.
Title: PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain.
DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis.
Title: DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis.
Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands.
Title: Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands.
A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice.
Title: A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice.
Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells.
Title: Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells.
MRGPRX2 mediates immediate-type pseudo-allergic reactions induced by iodine-containing iohexol.
Title: MRGPRX2 mediates immediate-type pseudo-allergic reactions induced by iodine-containing iohexol.
granuloma formation during intrathecal morphine infusion was associated with MrgprB2/X2. Reducing MRGPRX2 potentially blocks morphine-induced side effects, including granuloma formation.
Title: A Mast Cell-Specific Receptor Is Critical for Granuloma Induced by Intrathecal Morphine Infusion.
Gold chloride induces a pseudo-allergic reaction via MRGPRX2 both in vitro and in vivo.
Title: Gold induces a pseudo-allergic reaction via MRGPRX2 both in vitro and in vivo.
The N-methyl substitution on the side chain of these drugs played a significant role in activating MRGPRX2.
Title: Phenothiazine antipsychotics exhibit dual properties in pseudo-allergic reactions: Activating MRGPRX2 and inhibiting the H(1) receptor.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables mast cell secretagogue receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mast cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in mast cell degranulation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mas-related G-protein coupled receptor member X2

Names: MAS-related GPR, member B10; mas-related G-protein coupled receptor member B10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034868.3 → NP_001030040.2 mas-related G-protein coupled receptor member X2

See identical proteins and their annotated locations for NP_001030040.2

Status: VALIDATED

Source sequence(s)

AC115742, AK148121, AK148319, CJ131827

Consensus CDS

CCDS52258.1

UniProtKB/Swiss-Prot

E9PV62, Q3UG50, W8W3J9

UniProtKB/TrEMBL

B9EIX9

Related

ENSMUSP00000127022.2, ENSMUST00000098433.5

Conserved Domains (3) summary

pfam00001
Location:59 → 290

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl11424
Location:117 → 256

nitrilase; Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes

cl21561
Location:50 → 183

7tm_4; Olfactory receptor