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    Itih4 inter-alpha-trypsin inhibitor heavy chain 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54404, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Itih4provided by RGD
    Official Full Name
    inter-alpha-trypsin inhibitor heavy chain 4provided by RGD
    Primary source
    RGD:70881
    See related
    EnsemblRapid:ENSRNOG00000017381 AllianceGenome:RGD:70881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in acute-phase response and response to cytokine. Located in extracellular space. Biomarker of amyotrophic lateral sclerosis and obesity. Human ortholog(s) of this gene implicated in intermediate coronary syndrome and myocardial infarction. Orthologous to human ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 13454.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Itih4 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6086985..6102162)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6080539..6095710)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (6970367..6985538)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482447 Neighboring gene musculoskeletal, embryonic nuclear protein 1 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 3 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of potential urine proteins and microRNA biomarkers for the diagnosis of pulmonary tuberculosis patients. Wang J, et al. Emerg Microbes Infect, 2018 Apr 11. PMID 29636444, Free PMC Article
    2. Proteomic demonstration of the recurrent presence of inter-alpha-inhibitor H4 heavy-chain during aspergillosis induced in an animal model. Desoubeaux G, et al. Int J Med Microbiol, 2014 May. PMID 24360996
    3. The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human. Soury E, et al. Biochem Biophys Res Commun, 1998 Feb 13. PMID 9480842
    4. ITIH4, as an inflammation biomarker, mainly increases in bacterial bloodstream infection. Ma Y, et al. Cytokine, 2021 Feb. PMID 33348064
    5. ITIH4 serum concentration increases during acute-phase processes in human patients and is up-regulated by interleukin-6 in hepatocarcinoma HepG2 cells. Piñeiro M, et al. Biochem Biophys Res Commun, 1999 Sep 16. PMID 10486281

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables hyaluronic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acute-phase response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in response to cytokine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inter-alpha-trypsin inhibitor heavy chain H4
    Names
    inter-alpha-inhibitor H4 heavy chain
    inter-alpha-trypsin inhibitor heavy chain family, member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019369.2 → NP_062242.2  inter-alpha-trypsin inhibitor heavy chain H4 precursor

      See identical proteins and their annotated locations for NP_062242.2

      Status: VALIDATED

      Source sequence(s)
      BC089806
      UniProtKB/TrEMBL
      D3ZFC6, F7EYF5, Q5EBC0
      Related
      ENSRNOP00000058007.2, ENSRNOT00000061294.6
      Conserved Domains (3) summary
      smart00609
      Location:24 → 148
      VIT; Vault protein Inter-alpha-Trypsin domain
      cd01461
      Location:271 → 452
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      TIGR03788
      Location:40 → 592
      marine_srt_targ; marine proteobacterial sortase target protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      6086985..6102162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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