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    Fndc3b fibronectin type III domain containing 3B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fndc3bprovided by RGD
    Official Full Name
    fibronectin type III domain containing 3Bprovided by RGD
    Primary source
    RGD:1311673
    See related
    EnsemblRapid:ENSRNOG00000024089 AllianceGenome:RGD:1311673
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311673
    Summary
    Predicted to act upstream of or within several processes, including negative regulation of osteoblast differentiation; substrate adhesion-dependent cell spreading; and type II pneumocyte differentiation. Predicted to be located in endoplasmic reticulum. Orthologous to human FNDC3B (fibronectin type III domain containing 3B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 184.7), Adrenal (RPKM 174.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fndc3b in Genome Data Viewer
    Location:
    2q24
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (112240108..112546113, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (110311439..110617504, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (113109949..113415171, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene U1 small nuclear ribonucleoprotein C-like Neighboring gene growth hormone secretagogue receptor Neighboring gene uncharacterized LOC134485892 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene cyclin-dependent kinase 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fad104, a positive regulator of adipogenesis, negatively regulates osteoblast differentiation. Kishimoto K, et al. Biochem Biophys Res Commun, 2010 Jun 25. PMID 20493170
    2. Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration. Nishizuka M, et al. Exp Cell Res, 2009 Mar 10. PMID 19138685
    3. The novel gene fad104, containing a fibronectin type III domain, has a significant role in adipogenesis. Tominaga K, et al. FEBS Lett, 2004 Nov 5. PMID 15527760
    4. Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation. Kishimoto K, et al. Exp Cell Res, 2011 Sep 10. PMID 21704616
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within type II pneumocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibronectin type III domain-containing protein 3B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191704.1 → NP_001178633.1  fibronectin type III domain-containing protein 3B

      See identical proteins and their annotated locations for NP_001178633.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D4A0W7
      Related
      ENSRNOP00000106352.1, ENSRNOT00000154172.1
      Conserved Domains (2) summary
      cd00063
      Location:674 → 765
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:889 → 950
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      112240108..112546113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281559.1 → XP_063137629.1  fibronectin type III domain-containing protein 3B isoform X2

      Related
      ENSRNOP00000098843.1, ENSRNOT00000152014.1

    2. XM_006232215.5 → XP_006232277.1  fibronectin type III domain-containing protein 3B isoform X1

      See identical proteins and their annotated locations for XP_006232277.1

      UniProtKB/TrEMBL
      D4A0W7
      Conserved Domains (2) summary
      cd00063
      Location:674 → 765
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:889 → 950
      fn3; Fibronectin type III domain

    3. XM_039101977.2 → XP_038957905.1  fibronectin type III domain-containing protein 3B isoform X1

      UniProtKB/TrEMBL
      D4A0W7
      Conserved Domains (2) summary
      cd00063
      Location:674 → 765
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:889 → 950
      fn3; Fibronectin type III domain

    4. XM_006232216.5 → XP_006232278.1  fibronectin type III domain-containing protein 3B isoform X1

      See identical proteins and their annotated locations for XP_006232278.1

      UniProtKB/TrEMBL
      D4A0W7
      Conserved Domains (2) summary
      cd00063
      Location:674 → 765
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:889 → 950
      fn3; Fibronectin type III domain

    5. XM_063281557.1 → XP_063137627.1  fibronectin type III domain-containing protein 3B isoform X1

      UniProtKB/TrEMBL
      D4A0W7

    6. XM_063281558.1 → XP_063137628.1  fibronectin type III domain-containing protein 3B isoform X1

      UniProtKB/TrEMBL
      D4A0W7
    Nucleotide Protein Strain
    Heading Accession and Version

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