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    Cr2 complement C3d receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289395, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cr2provided by RGD
    Official Full Name
    complement C3d receptor 2provided by RGD
    Primary source
    RGD:1310065
    See related
    EnsemblRapid:ENSRNOG00000034164 AllianceGenome:RGD:1310065
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cd21
    Summary
    Predicted to enable several functions, including complement receptor activity; immunoglobulin receptor binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including B cell activation; negative regulation of complement activation, classical pathway; and type I interferon-mediated signaling pathway. Predicted to act upstream of or within with a negative effect on complement activation, alternative pathway. Predicted to act upstream of or within several processes, including cellular response to lipopolysaccharide; immunoglobulin mediated immune response; and skeletal system development. Located in cell surface and extracellular space. Human ortholog(s) of this gene implicated in common variable immunodeficiency 7; nasopharynx carcinoma; and systemic lupus erythematosus. Orthologous to human CR2 (complement C3d receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1089.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cr2 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (109207034..109244980, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (106678579..106716595, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (113890274..113927824, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene CD46 molecule Neighboring gene uncharacterized LOC108352604 Neighboring gene complement C3b/C4b receptor 1 like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120096211

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice. Kane SJ, et al. mSphere, 2017 Nov-Dec. PMID 29202042, Free PMC Article
    2. Phthalide derivative CD21 regulates the platelet- neutrophil extracellular trap-thrombin axis and protects against ischemic brain injury in rodents. Wu ML, et al. Int Immunopharmacol, 2023 Jan. PMID 36527877
    3. In vivo decrease in the expression of complement receptor 2 on B-cells in HIV infection. Scott ME, et al. AIDS, 1993 Jan. PMID 8442917
    4. Characterization of C3 receptors on cultured rat glomerular endothelial cells. Alexander JJ, et al. Kidney Int, 1997 Apr. PMID 9083278
    5. Complement and natural antibody are required in the long-term memory response to influenza virus. Fernandez Gonzalez S, et al. Vaccine, 2008 Dec 30. PMID 19388171

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phthalide derivative CD21 regulates the platelet- neutrophil extracellular trap-thrombin axis and protects against ischemic brain injury in rodents.
      Title: Phthalide derivative CD21 regulates the platelet- neutrophil extracellular trap-thrombin axis and protects against ischemic brain injury in rodents.
    2. CD21 is expressed in the rat mucosal mast cell line RBL-2H3
      Title: Mucosal type mast cells express complement receptor type 2 (CD21).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables complement binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables complement receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables immunoglobulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell mediated immunity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cartilage development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within_negative_effect complement activation, alternative pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in complement activation, alternative pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in complement receptor mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immunoglobulin mediated immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in symbiont entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement receptor type 2
    Names
    complement component (3d/Epstein Barr virus) receptor 2
    complement component 3d receptor 2
    complement receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105989.2 → NP_001099459.2  complement receptor type 2 precursor

      See identical proteins and their annotated locations for NP_001099459.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JH50
      Conserved Domains (2) summary
      cd00033
      Location:719 → 775
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:711 → 964
      PHA02927; secreted complement-binding protein; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      109207034..109244980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769847.4 → XP_008768069.1  complement receptor type 2 isoform X1

      UniProtKB/TrEMBL
      D3Z9F7
      Related
      ENSRNOP00000010910.7, ENSRNOT00000010910.8
      Conserved Domains (4) summary
      cd00033
      Location:1096 → 1152
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:83 → 140
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:10 → 274
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:337 → 395
      Sushi; Sushi repeat (SCR repeat)

    2. XM_063272195.1 → XP_063128265.1  complement receptor type 2 isoform X2

      UniProtKB/TrEMBL
      A6JH50
    Nucleotide Protein Strain
    Heading Accession and Version

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