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    Ep400 E1A binding protein p400 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304569, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ep400provided by RGD
    Official Full Name
    E1A binding protein p400provided by RGD
    Primary source
    RGD:1304733
    See related
    EnsemblRapid:ENSRNOG00000037483 AllianceGenome:RGD:1304733
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables chromatin binding activity and protein antigen binding activity. Predicted to be involved in DNA repair; positive regulation of double-strand break repair via homologous recombination; and regulation of cell cycle. Predicted to be located in nuclear speck. Predicted to be part of NuA4 histone acetyltransferase complex; Swr1 complex; and nucleosome. Orthologous to human EP400 (E1A binding protein p400). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 133.1), Thymus (RPKM 132.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ep400 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    58
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (51551665..51658635)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (45891886..46002523)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (51948650..52055274)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene unc-51 like autophagy activating kinase 1 Neighboring gene uncharacterized LOC120096017 Neighboring gene pseudouridine synthase 1 Neighboring gene replication protein A3 like 1 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA, H/ACA box 49 Neighboring gene DEAD-box helicase 51 Neighboring gene nucleolar complex associated 4 homolog Neighboring gene uncharacterized LOC134481216

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen. Lill NL, et al. J Virol, 1997 Jan. PMID 8985331, Free PMC Article
    2. MYC recruits the TIP60 histone acetyltransferase complex to chromatin. Frank SR, et al. EMBO Rep, 2003 Jun. PMID 12776177, Free PMC Article
    3. PHF5A represents a bridge protein between splicing proteins and ATP-dependent helicases and is differentially expressed during mouse spermatogenesis. Rzymski T, et al. Cytogenet Genome Res, 2008. PMID 18758164
    4. ANP32E is a histone chaperone that removes H2A.Z from chromatin. Obri A, et al. Nature, 2014 Jan 30. PMID 24463511
    5. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein antigen binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Swr1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Swr1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E1A-binding protein p400

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107149.1 → NP_001100619.1  E1A-binding protein p400

      See identical proteins and their annotated locations for NP_001100619.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A0A8I6G935, A6J294, D3ZQ89
      Related
      ENSRNOP00000053578.2, ENSRNOT00000056735.5
      Conserved Domains (6) summary
      smart00573
      Location:762 → 833
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:1073 → 1208
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:1056 → 1336
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1778 → 1894
      Helicase_C; Helicase conserved C-terminal domain
      pfam09309
      Location:533 → 625
      FCP1_C; FCP1, C-terminal
      pfam15790
      Location:1 → 469
      EP400_N; E1A-binding protein p400, N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      51551665..51658635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271366.1 → XP_063127436.1  E1A-binding protein p400 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G935

    2. XM_063271372.1 → XP_063127442.1  E1A-binding protein p400 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G935

    3. XM_063271373.1 → XP_063127443.1  E1A-binding protein p400 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JU09, A0A8I6G935

    4. XM_063271383.1 → XP_063127453.1  E1A-binding protein p400 isoform X7

      UniProtKB/TrEMBL
      A0A8I6G935

    5. XM_063271374.1 → XP_063127444.1  E1A-binding protein p400 isoform X4

      UniProtKB/TrEMBL
      A0A8I6G935

    6. XM_063271375.1 → XP_063127445.1  E1A-binding protein p400 isoform X5

      UniProtKB/TrEMBL
      A0A8I6G935

    7. XM_063271388.1 → XP_063127458.1  E1A-binding protein p400 isoform X12

      UniProtKB/TrEMBL
      A0A8I6G935

    8. XM_063271384.1 → XP_063127454.1  E1A-binding protein p400 isoform X8

      UniProtKB/TrEMBL
      A0A8I6G935

    9. XM_063271389.1 → XP_063127459.1  E1A-binding protein p400 isoform X13

      UniProtKB/TrEMBL
      A0A8I6G935, A6J294, D3ZQ89

    10. XM_063271379.1 → XP_063127449.1  E1A-binding protein p400 isoform X6

      UniProtKB/TrEMBL
      A0A8I6G935

    11. XM_063271385.1 → XP_063127455.1  E1A-binding protein p400 isoform X9

      UniProtKB/TrEMBL
      A0A8I6G935

    12. XM_063271390.1 → XP_063127460.1  E1A-binding protein p400 isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZTE5, A0A8I6G935
      Related
      ENSRNOP00000081678.1, ENSRNOT00000118850.2

    13. XM_063271369.1 → XP_063127439.1  E1A-binding protein p400 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G935

    14. XM_063271376.1 → XP_063127446.1  E1A-binding protein p400 isoform X5

      UniProtKB/TrEMBL
      A0A8I6G935

    15. XM_063271382.1 → XP_063127452.1  E1A-binding protein p400 isoform X6

      UniProtKB/TrEMBL
      A0A8I6G935

    16. XM_063271368.1 → XP_063127438.1  E1A-binding protein p400 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G935

    17. XM_063271367.1 → XP_063127437.1  E1A-binding protein p400 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G935

    18. XM_063271377.1 → XP_063127447.1  E1A-binding protein p400 isoform X5

      UniProtKB/TrEMBL
      A0A8I6G935

    19. XM_063271380.1 → XP_063127450.1  E1A-binding protein p400 isoform X6

      UniProtKB/TrEMBL
      A0A8I6G935

    20. XM_063271371.1 → XP_063127441.1  E1A-binding protein p400 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G935
      Related
      ENSRNOP00000068916.1, ENSRNOT00000084214.3

    21. XM_063271378.1 → XP_063127448.1  E1A-binding protein p400 isoform X5

      UniProtKB/TrEMBL
      A0A8I6G935

    22. XM_063271386.1 → XP_063127456.1  E1A-binding protein p400 isoform X10

      UniProtKB/TrEMBL
      A0A8I6G935

    23. XM_063271387.1 → XP_063127457.1  E1A-binding protein p400 isoform X11

      UniProtKB/TrEMBL
      A0A8I6G935
    Nucleotide Protein Strain
    Heading Accession and Version

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