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    Nfu1 NFU1 iron-sulfur cluster scaffold [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297416, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nfu1provided by RGD
    Official Full Name
    NFU1 iron-sulfur cluster scaffoldprovided by RGD
    Primary source
    RGD:1307823
    See related
    EnsemblRapid:ENSRNOG00000018410 AllianceGenome:RGD:1307823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hirip5
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity; 4 iron, 4 sulfur cluster binding activity; and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly; protein maturation by [2Fe-2S] cluster transfer; and protein maturation by [4Fe-4S] cluster transfer. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 1. Orthologous to human NFU1 (NFU1 iron-sulfur cluster scaffold). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 150.5), Muscle (RPKM 128.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nfu1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (121016316..121036925)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (119458981..119480162)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (118814284..118834955)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene AP2 associated kinase 1 Neighboring gene uncharacterized LOC134486608 Neighboring gene uncharacterized LOC120102328 Neighboring gene glutamine fructose-6-phosphate transaminase 1 Neighboring gene ANTXR cell adhesion molecule 1 Neighboring gene uncharacterized LOC120102329

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Single Mutation in the NFU1 Gene Metabolically Reprograms Pulmonary Artery Smooth Muscle Cells. James J, et al. Arterioscler Thromb Vasc Biol, 2021 Feb. PMID 33297749, Free PMC Article
    2. Understanding the molecular basis for multiple mitochondrial dysfunctions syndrome 1 (MMDS1): impact of a disease-causing Gly189Arg substitution on NFU1. Wesley NA, et al. FEBS J, 2017 Nov. PMID 28906594, Free PMC Article
    3. The Lafora disease gene product laforin interacts with HIRIP5, a phylogenetically conserved protein containing a NifU-like domain. Ganesh S, et al. Hum Mol Genet, 2003 Sep 15. PMID 12915448
    4. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N, et al. Biochim Biophys Acta, 2015 Jun. PMID 25245479, Free PMC Article
    5. Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster. Tong WH, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12886008, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single Mutation in the NFU1 Gene Metabolically Reprograms Pulmonary Artery Smooth Muscle Cells.
      Title: Single Mutation in the NFU1 Gene Metabolically Reprograms Pulmonary Artery Smooth Muscle Cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation by [2Fe-2S] cluster transfer ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation by [4Fe-4S] cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
    Names
    histone cell cycle regulation defective interacting protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106606.2 → NP_001100076.2  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001100076.2

      Status: VALIDATED

      Source sequence(s)
      FM058785, FM064033, FM092780
      UniProtKB/TrEMBL
      A6IAZ7, D3ZA85
      Related
      ENSRNOP00000024884.6, ENSRNOT00000024884.8
      Conserved Domains (2) summary
      smart00932
      Location:59 → 146
      Nfu_N; Scaffold protein Nfu/NifU N terminal
      pfam01106
      Location:171 → 237
      NifU; NifU-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      121016316..121036925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285813.1 → XP_063141883.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X1

      UniProtKB/TrEMBL
      D3ZA85

    2. XM_063285814.1 → XP_063141884.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X2

    3. XM_039107363.2 → XP_038963291.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X4

      Conserved Domains (2) summary
      pfam01106
      Location:81 → 147
      NifU; NifU-like domain
      cl07364
      Location:33 → 56
      Nfu_N; Scaffold protein Nfu/NifU N terminal

    4. XM_063285815.1 → XP_063141885.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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