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    Unk unk zinc finger [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Unkprovided by RGD
    Official Full Name
    unk zinc fingerprovided by RGD
    Primary source
    RGD:1309224
    See related
    EnsemblRapid:ENSRNOG00000006600 AllianceGenome:RGD:1309224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zc3h5; Zc3hdc5
    Summary
    Predicted to enable mRNA CDS binding activity and ribosome binding activity. Predicted to be involved in cell morphogenesis involved in neuron differentiation and negative regulation of cytoplasmic translation. Predicted to act upstream of or within in utero embryonic development and neuron migration. Predicted to be located in cytoplasm. Orthologous to human UNK (unk zinc finger). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 55.0), Spleen (RPKM 45.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Unk in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101764732..101794847)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101265732..101295950)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (104582531..104613102)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene translation machinery-associated protein 7-like Neighboring gene H3.3 histone B Neighboring gene uncharacterized LOC134480906 Neighboring gene unc-13 homolog D Neighboring gene WW domain binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
    2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA CDS binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA CDS binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell morphogenesis involved in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis involved in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein unkempt homolog
    Names
    unkempt family zinc finger
    unkempt homolog
    zinc finger CCCH type containing 5
    zinc finger CCCH type domain containing 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430241.1 → NP_001417170.1  RING finger protein unkempt homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6ARP1, D3ZV40

    2. NM_001430242.1 → NP_001417171.1  RING finger protein unkempt homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6ARP1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      101764732..101794847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003750953.5 → XP_003751001.1  RING finger protein unkempt homolog isoform X1

      Related
      ENSRNOP00000009733.6, ENSRNOT00000009733.9
      Conserved Domains (4) summary
      COG5063
      Location:124 → 318
      CTH1; CCCH-type Zn-finger protein [General function prediction only]
      pfam00642
      Location:294 → 318
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam05384
      Location:646 → 719
      DegS; Sensor protein DegS
      pfam13920
      Location:765 → 801
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    2. XM_003750954.6 → XP_003751002.1  RING finger protein unkempt homolog isoform X2

      Conserved Domains (4) summary
      COG5063
      Location:124 → 318
      CTH1; CCCH-type Zn-finger protein [General function prediction only]
      pfam00642
      Location:294 → 318
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam05384
      Location:633 → 706
      DegS; Sensor protein DegS
      pfam13920
      Location:752 → 788
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    3. XM_039087811.2 → XP_038943739.1  RING finger protein unkempt homolog isoform X3

      Conserved Domains (3) summary
      PHA03307
      Location:308 → 571
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam18384
      Location:34 → 69
      zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)
      pfam00642
      Location:294 → 318
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    RNA

    1. XR_005490797.2 RNA Sequence

    2. XR_010055883.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108306.1: Suppressed sequence

      Description
      NM_001108306.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: UNK (GeneID:85451).
    Nucleotide Protein Strain
    Heading Accession and Version

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