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    Mtrf1l mitochondrial translational release factor 1-like [ Mus musculus (house mouse) ]

    Gene ID: 108853, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mtrf1lprovided by MGI
    Official Full Name
    mitochondrial translational release factor 1-likeprovided by MGI
    Primary source
    MGI:MGI:1918830
    See related
    Ensembl:ENSMUSG00000019774 AllianceGenome:MGI:1918830
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130004K12Rik
    Summary
    Predicted to enable translation release factor activity, codon specific. Predicted to be involved in mitochondrial translational termination. Located in mitochondrion. Orthologous to human MTRF1L (mitochondrial translation release factor 1 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.0), limb E14.5 (RPKM 1.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtrf1l in Genome Data Viewer
    Location:
    10 A1; 10 1.91 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (5760151..5775015, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (5811119..5825015, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25595 Neighboring gene predicted gene, 30617 Neighboring gene STARR-positive B cell enhancer ABC_E3873 Neighboring gene STARR-positive B cell enhancer ABC_E3872 Neighboring gene predicted gene, 53609 Neighboring gene F-box protein 5 Neighboring gene STARR-seq mESC enhancer starr_25593 Neighboring gene regulator of G-protein signaling 17 Neighboring gene predicted gene, 18902 Neighboring gene STARR-seq mESC enhancer starr_25590 Neighboring gene STARR-seq mESC enhancer starr_25589 Neighboring gene STARR-seq mESC enhancer starr_25588 Neighboring gene STARR-seq mESC enhancer starr_25586 Neighboring gene predicted gene 3213

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables translation release factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation release factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation release factor activity, codon specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation release factor activity, codon specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial translational termination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peptide chain release factor 1-like, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175374.3 → NP_780583.1  peptide chain release factor 1-like, mitochondrial precursor

      See identical proteins and their annotated locations for NP_780583.1

      Status: VALIDATED

      Source sequence(s)
      AI510282, AK036424, AK078897
      Consensus CDS
      CCDS56684.1
      UniProtKB/Swiss-Prot
      Q8BJU9
      Related
      ENSMUSP00000019908.9, ENSMUST00000019908.9
      Conserved Domains (3) summary
      COG1186
      Location:123 → 355
      PrfB; Protein chain release factor B [Translation, ribosomal structure and biogenesis]
      pfam00472
      Location:224 → 329
      RF-1; RF-1 domain
      pfam03462
      Location:57 → 214
      PCRF; PCRF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      5760151..5775015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_380033.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJU9.1 GenPept UniProtKB/Swiss-Prot:Q8BJU9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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