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    Stard3nl STARD3 N-terminal like [ Mus musculus (house mouse) ]

    Gene ID: 76205, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Stard3nlprovided by MGI
    Official Full Name
    STARD3 N-terminal likeprovided by MGI
    Primary source
    MGI:MGI:1923455
    See related
    Ensembl:ENSMUSG00000003062 AllianceGenome:MGI:1923455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MENTHO; 0610035N01Rik; 6530409L22Rik
    Summary
    Predicted to enable cholesterol binding activity and protein homodimerization activity. Predicted to be involved in cholesterol transport and vesicle tethering to endoplasmic reticulum. Predicted to be located in endosome and organelle membrane contact site. Predicted to be active in endoplasmic reticulum-endosome membrane contact site and late endosome membrane. Predicted to colocalize with endoplasmic reticulum membrane. Is expressed in respiratory system cartilage; sensory organ; skeleton; and tarsus. Orthologous to human STARD3NL (STARD3 N-terminal like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 24.1), whole brain E14.5 (RPKM 18.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stard3nl in Genome Data Viewer
    Location:
    13 A2; 13 6.89 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (19541846..19579983, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (19357676..19395813, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene T cell receptor gamma chain Neighboring gene T cell receptor gamma joining 4 Neighboring gene T cell receptor gamma, constant 4 Neighboring gene STARR-seq mESC enhancer starr_33793 Neighboring gene STARR-positive B cell enhancer mm9_chr13:19487566-19487867 Neighboring gene predicted gene, 40827 Neighboring gene STARR-seq mESC enhancer starr_33795 Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene RIKEN cDNA 9330199G10 gene Neighboring gene STARR-seq mESC enhancer starr_33796

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MENTHO, a MLN64 homologue devoid of the START domain. Alpy F, et al. J Biol Chem, 2002 Dec 27. PMID 12393907
    2. STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2 in osteoporosis. Xu Y, et al. J Cell Mol Med, 2022 Mar. PMID 35098646, Free PMC Article
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    5. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/beta-catenin pathway via binding to Annexin A2 in osteoporosis.
      Title: STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2 in osteoporosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cholesterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle tethering to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle tethering to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle tethering to endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum-endosome membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-endosome membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-endosome membrane contact site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in organelle membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane contact site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    STARD3 N-terminal-like protein
    Names
    MLN64 N-terminal domain homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347485.1 → NP_001334414.1  STARD3 N-terminal-like protein isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is longer than isoform a.
      Source sequence(s)
      AK018331, BG071347, CJ135250, DV648392
      Consensus CDS
      CCDS84008.1
      UniProtKB/TrEMBL
      A0A0G2JE93, Q3U852
      Related
      ENSMUSP00000142680.2, ENSMUST00000200323.3

    2. NM_024270.3 → NP_077232.2  STARD3 N-terminal-like protein isoform a

      See identical proteins and their annotated locations for NP_077232.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (a).
      Source sequence(s)
      BG084215, BP772163, CO039188, DV648392
      Consensus CDS
      CCDS26259.1
      UniProtKB/Swiss-Prot
      Q3U8Q7, Q99J63, Q9D356, Q9DCI3
      UniProtKB/TrEMBL
      Q3U852
      Related
      ENSMUSP00000037991.8, ENSMUST00000039694.13
      Conserved Domains (1) summary
      pfam10457
      Location:49 → 212
      MENTAL; Cholesterol-capturing domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      19541846..19579983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158216.1 → XP_036014109.1  STARD3 N-terminal-like protein isoform X2

      UniProtKB/TrEMBL
      Q3U852
      Conserved Domains (1) summary
      pfam10457
      Location:104 → 267
      MENTAL; Cholesterol-capturing domain

    2. XM_036158217.1 → XP_036014110.1  STARD3 N-terminal-like protein isoform X3

      UniProtKB/Swiss-Prot
      Q3U8Q7, Q99J63, Q9D356, Q9DCI3
      UniProtKB/TrEMBL
      Q3U852
      Conserved Domains (1) summary
      pfam10457
      Location:49 → 212
      MENTAL; Cholesterol-capturing domain

    3. XM_030247456.1 → XP_030103316.1  STARD3 N-terminal-like protein isoform X3

      UniProtKB/Swiss-Prot
      Q3U8Q7, Q99J63, Q9D356, Q9DCI3
      UniProtKB/TrEMBL
      Q3U852
      Conserved Domains (1) summary
      pfam10457
      Location:49 → 212
      MENTAL; Cholesterol-capturing domain

    4. XM_030247454.2 → XP_030103314.1  STARD3 N-terminal-like protein isoform X1

      Conserved Domains (1) summary
      pfam10457
      Location:104 → 268
      MENTAL; Cholesterol-capturing domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCI3.2 GenPept UniProtKB/Swiss-Prot:Q9DCI3

    Gene LinkOut

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