Nadk2 NAD kinase 2, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nadk2provided by MGI
Official Full Name: NAD kinase 2, mitochondrialprovided by MGI
Primary source: MGI:MGI:1915896
See related: Ensembl:ENSMUSG00000022253 AllianceGenome:MGI:1915896
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MNADK; Nadkd1
Summary: Predicted to enable NAD+ kinase activity and protein homodimerization activity. Predicted to be involved in NAD metabolic process. Located in mitochondrion. Is expressed in retina. Orthologous to human NADK2 (NAD kinase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14 (RPKM 40.2), liver E14.5 (RPKM 34.4) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 3.82 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (9071340..9110584)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (9071260..9110496)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Coxsackie virus B3 (CVB3) triggers the activation of NLRP3 in mouse macrophages by activating nicotinamide adenine dinucleotide kinase 2 (NADK2)].
Title: [Coxsackie virus B3 (CVB3) triggers the activation of NLRP3 in mouse macrophages by activating nicotinamide adenine dinucleotide kinase 2 (NADK2)].
Mouse models of NADK2 deficiency analyzed for metabolic and gene expression changes to elucidate pathophysiology.
Title: Mouse models of NADK2 deficiency analyzed for metabolic and gene expression changes to elucidate pathophysiology.
Deleting MNADK (NADK2) in mice reduced fat oxidation upon energy demand triggered by endurance exercise or fasting. NADK2 is a major metabolic regulator upon increased energy demand.
Title: The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand.
MNADK is localized to mitochondria in Hep G2 cells, and a recombinant MNADK showed NAD kinase activity. MNADK is abundant in mitochondrion-rich tissues, such as liver. MNADK expression was suppressed in human liver tumors. Identification of MNADK immediately suggests a model in which NADK and MNADK are responsible for de novo synthesis of NADP(+) in cytosol and mitochondria, respectively.
Title: MNADK, a novel liver-enriched mitochondrion-localized NAD kinase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (3)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables NAD+ kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ kinase activity	ISO Inferred from Sequence Orthology more info
enables NAD+ kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in NAD metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in NAD metabolic process	ISO Inferred from Sequence Orthology more info
involved_in NAD metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in NADP biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NAD kinase 2, mitochondrial

Names: NAD kinase domain-containing protein 1, mitochondrial

NP_001035485.2

EC 2.7.1.23

NP_001078879.1

EC 2.7.1.23

NP_001273182.1

EC 2.7.1.23

NP_001273184.1

EC 2.7.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040395.4 → NP_001035485.2 NAD kinase 2, mitochondrial isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AK046666, AK078318, AK162601, AW537715, BE692075, BY545448

UniProtKB/TrEMBL

Q14BL1

Conserved Domains (1) summary

cl01255
Location:84 → 306

DAGK_cat; Diacylglycerol kinase catalytic domain
NM_001085410.2 → NP_001078879.1 NAD kinase 2, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_001078879.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK046666, AK078318, AK162601, AW537715, BE692075, BY545448

UniProtKB/Swiss-Prot

Q3TRP5, Q3UEY1, Q8C5H8, Q9CTE4

UniProtKB/TrEMBL

Q14BL1

Related

ENSMUSP00000159405.2, ENSMUST00000190591.10

Conserved Domains (1) summary

cl01255
Location:84 → 328

DAGK_cat; Diacylglycerol kinase catalytic domain
NM_001286253.1 → NP_001273182.1 NAD kinase 2, mitochondrial isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, lacks several additional exons, and its 3' terminal exon extends past a splice site that is used in variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK016988, AK046666, BF460794

UniProtKB/TrEMBL

A0A7P0A156

Related

ENSMUSP00000159408.2, ENSMUST00000190874.8

Conserved Domains (1) summary

cl01255
Location:84 → 306

DAGK_cat; Diacylglycerol kinase catalytic domain
NM_001286255.1 → NP_001273184.1 NAD kinase 2, mitochondrial isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.

Source sequence(s)

AK046666, AK078318, AK162601, AW537715, BE692075, BY545448

UniProtKB/TrEMBL

A0A7N9VS49

Related

ENSMUSP00000159407.2, ENSMUST00000189437.8

Conserved Domains (1) summary

cl01255
Location:84 → 278

DAGK_cat; Diacylglycerol kinase catalytic domain