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    Iigp1c interferon inducible GTPase 1C [ Mus musculus (house mouse) ]

    Gene ID: 240327, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Iigp1cprovided by MGI
    Official Full Name
    interferon inducible GTPase 1Cprovided by MGI
    Primary source
    MGI:MGI:3644953
    See related
    Ensembl:ENSMUSG00000073555 AllianceGenome:MGI:3644953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm4951; Ifgga2; EG240327
    Summary
    Predicted to enable GTPase activity. Acts upstream of or within cellular response to interferon-beta. Predicted to be active in endoplasmic reticulum membrane. Used to study metabolic dysfunction-associated steatotic liver disease. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 5.3), liver adult (RPKM 4.7) and 3 other tissues See more
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    Genomic context

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    See Iigp1c in Genome Data Viewer
    Location:
    18 D3; 18 34.36 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (60345064..60381512)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60212004..60248440)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54034 Neighboring gene STARR-seq mESC enhancer starr_44711 Neighboring gene STARR-seq mESC enhancer starr_44712 Neighboring gene zinc finger protein 12 pseudogene Neighboring gene interferon inducible GTPase 1 pseudogene Neighboring gene predicted gene, 45947 Neighboring gene predicted gene, 46635 Neighboring gene predicted gene 4841

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity. Zhang Z, et al. Nat Commun, 2022 Jul 16. PMID 35842425, Free PMC Article
    2. Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation. Schwerbel K, et al. J Hepatol, 2020 Oct. PMID 32376415, Free PMC Article
    3. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Bürckstümmer T, et al. Nat Immunol, 2009 Mar. PMID 19158679
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to interferon-beta IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC240327
    Names
    interferon-gamma-inducible GTPase Ifgga2 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033767.4 → NP_001028939.1  uncharacterized protein LOC240327

      See identical proteins and their annotated locations for NP_001028939.1

      Status: VALIDATED

      Source sequence(s)
      AC102225
      Consensus CDS
      CCDS29268.1
      UniProtKB/TrEMBL
      Q3UED7, U5NJM4
      Related
      ENSMUSP00000031549.6, ENSMUST00000031549.6
      Conserved Domains (1) summary
      pfam05049
      Location:36 → 402
      IIGP; Interferon-inducible GTPase (IIGP)

    2. NM_001429146.1 → NP_001416075.1  uncharacterized protein LOC240327

      Status: VALIDATED

      Source sequence(s)
      AC102225
      UniProtKB/TrEMBL
      Q3UED7

    3. NM_001429147.1 → NP_001416076.1  uncharacterized protein LOC240327

      Status: VALIDATED

      Source sequence(s)
      AC102225
      UniProtKB/TrEMBL
      Q3UED7

    4. NM_001429148.1 → NP_001416077.1  uncharacterized protein LOC240327

      Status: VALIDATED

      Source sequence(s)
      AC102225
      UniProtKB/TrEMBL
      Q3UED7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      60345064..60381512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246928.4 → XP_011245230.1  uncharacterized protein LOC240327 isoform X1

      Conserved Domains (1) summary
      pfam05049
      Location:36 → 402
      IIGP; Interferon-inducible GTPase (IIGP)

    2. XM_011246929.4 → XP_011245231.1  uncharacterized protein LOC240327 isoform X1

      Conserved Domains (1) summary
      pfam05049
      Location:36 → 402
      IIGP; Interferon-inducible GTPase (IIGP)

    3. XM_006525925.5 → XP_006525988.1  uncharacterized protein LOC240327 isoform X1

      Conserved Domains (1) summary
      pfam05049
      Location:36 → 402
      IIGP; Interferon-inducible GTPase (IIGP)
    Nucleotide Protein Strain
    Heading Accession and Version

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