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    Adamtsl3 ADAMTS-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 269959, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Adamtsl3provided by MGI
    Official Full Name
    ADAMTS-like 3provided by MGI
    Primary source
    MGI:MGI:3028499
    See related
    Ensembl:ENSMUSG00000070469 AllianceGenome:MGI:3028499
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1233; C130057K09; 9230119C12Rik
    Summary
    Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular matrix. Is expressed in embryo. Orthologous to human ADAMTSL3 (ADAMTS like 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 4.3), limb E14.5 (RPKM 2.6) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adamtsl3 in Genome Data Viewer
    Location:
    7 D3; 7 47.18 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (81984612..82263658)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (82335399..82614450)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene SH3-domain GRB2-like 3 Neighboring gene STARR-seq mESC enhancer starr_19382 Neighboring gene STARR-seq mESC enhancer starr_19384 Neighboring gene predicted gene, 32903 Neighboring gene predicted gene, 51492 Neighboring gene stabilizer of axonemal microtubules 2 Neighboring gene VISTA enhancer mm1514 Neighboring gene elongation factor like GTPase 1 Neighboring gene RIKEN cDNA 4933406J10 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload. Rypdal KB, et al. Commun Biol, 2022 Dec 20. PMID 36539599, Free PMC Article
    2. ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases. Hall NG, et al. Matrix Biol, 2003 Nov. PMID 14667842
    3. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFbeta signalling after pressure overload.
      Title: ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1233

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADAMTS-like protein 3
    Names
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif like, 3
    punctin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190374.1 → NP_001177303.1  ADAMTS-like protein 3

      Status: PROVISIONAL

      Source sequence(s)
      AC110192, AC138270
      Consensus CDS
      CCDS57559.1
      UniProtKB/TrEMBL
      G3UXC7
      Related
      ENSMUSP00000133637.2, ENSMUST00000173287.8
      Conserved Domains (6) summary
      smart00408
      Location:1330 → 1388
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:90 → 136
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:1321 → 1393
      IG_like; Immunoglobulin like
      pfam08686
      Location:1674 → 1704
      PLAC; PLAC (protease and lacunin) domain
      cl11960
      Location:942 → 1006
      Ig; Immunoglobulin domain
      cl15278
      Location:1503 → 1558
      TSP_1; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      81984612..82263658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507893.4 → XP_006507956.1  ADAMTS-like protein 3 isoform X2

      Conserved Domains (4) summary
      smart00209
      Location:90 → 136
      TSP1; Thrombospondin type 1 repeats
      cd00096
      Location:1331 → 1393
      Ig; Immunoglobulin domain
      cl11960
      Location:942 → 1006
      Ig; Immunoglobulin domain
      cl15278
      Location:1503 → 1558
      TSP_1; Thrombospondin type 1 domain

    2. XM_036153144.1 → XP_036009037.1  ADAMTS-like protein 3 isoform X1

    3. XM_006507894.4 → XP_006507957.1  ADAMTS-like protein 3 isoform X3

      Conserved Domains (3) summary
      smart00209
      Location:90 → 136
      TSP1; Thrombospondin type 1 repeats
      cd00096
      Location:1224 → 1289
      Ig; Immunoglobulin domain
      cl11960
      Location:942 → 1006
      Ig; Immunoglobulin domain

    RNA

    1. XR_378247.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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