Tlr8 toll-like receptor 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tlr8provided by MGI
Official Full Name: toll-like receptor 8provided by MGI
Primary source: MGI:MGI:2176887
See related: Ensembl:ENSMUSG00000040522 AllianceGenome:MGI:2176887
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable identical protein binding activity; nucleic acid binding activity; and pattern recognition receptor activity. Acts upstream of or within regulation of protein phosphorylation. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Is expressed in brain and liver. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TLR8 (toll like receptor 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: X F5; X 78.29 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (166024119..166047325, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (167241123..167264329, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TLR8-activating miR-146a-3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS.
Title: TLR8-activating miR-146a-3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS.
Gender Control of Mouse Embryos by Activation of TLR7/8 on X Sperm via Ligands dsRNA-40 and dsRNA-DR.
Title: Gender Control of Mouse Embryos by Activation of TLR7/8 on X Sperm via Ligands dsRNA-40 and dsRNA-DR.
CD8 T Cell-Derived Exosomal miR-186-5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis.
Title: CD8 T Cell-Derived Exosomal miR-186-5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis.
TLR7/8 stress response drives histiocytosis in SLC29A3 disorders.
Title: TLR7/8 stress response drives histiocytosis in SLC29A3 disorders.
Expression of toll like receptor 8 (TLR8) in specific groups of mouse hippocampal interneurons.
Title: Expression of toll like receptor 8 (TLR8) in specific groups of mouse hippocampal interneurons.
Therapeutic efficacy of cancer vaccine adjuvanted with nanoemulsion loaded with TLR7/8 agonist in lung cancer model.
Title: Therapeutic efficacy of cancer vaccine adjuvanted with nanoemulsion loaded with TLR7/8 agonist in lung cancer model.
TLR8 in the Trigeminal Ganglion Contributes to the Maintenance of Trigeminal Neuropathic Pain in Mice.
Title: TLR8 in the Trigeminal Ganglion Contributes to the Maintenance of Trigeminal Neuropathic Pain in Mice.
Podocyte Injury Through Interaction Between Tlr8 and Its Endogenous Ligand miR-21 in Obstructed and Its Collateral Kidney.
Title: Podocyte Injury Through Interaction Between Tlr8 and Its Endogenous Ligand miR-21 in Obstructed and Its Collateral Kidney.
TLR7/8 in the Pathogenesis of Parkinson's Disease.
Title: TLR7/8 in the Pathogenesis of Parkinson's Disease.
Development of RNA/DNA Hydrogel Targeting Toll-Like Receptor 7/8 for Sustained RNA Release and Potent Immune Activation.
Title: Development of RNA/DNA Hydrogel Targeting Toll-Like Receptor 7/8 for Sustained RNA Release and Potent Immune Activation.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-alpha production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-6 production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 8 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 8 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: toll-like receptor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313760.1 → NP_001300689.1 toll-like receptor 8 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL731735, BC132054, BY210507

UniProtKB/Swiss-Prot

P58682

Conserved Domains (5) summary

PRK15370
Location:47 → 231

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00255
Location:868 → 1004

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:141 → 717

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:62 → 85

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:701 → 762

LRR_8; Leucine rich repeat
NM_001313761.1 → NP_001300690.1 toll-like receptor 8 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region and an alternate segment in the 3' end compared to variant 1. The transcript uses a downstream start codon compared to variant 1, resulting in an isoform (3) that is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL731735, BC132054, BY203258

UniProtKB/Swiss-Prot

P58682

Conserved Domains (4) summary

smart00255
Location:352 → 488

TIR; Toll - interleukin 1 - resistance

cd00116
Location:27 → 246

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:4 → 27

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:81 → 148

LRR_8; Leucine rich repeat
NM_133212.3 → NP_573475.2 toll-like receptor 8 isoform 1 precursor

See identical proteins and their annotated locations for NP_573475.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL731735, BC132054, BY203208

Consensus CDS

CCDS41209.1

UniProtKB/Swiss-Prot

A2AHI9, P58682, Q91XI7

Related

ENSMUSP00000107793.2, ENSMUST00000112170.2

Conserved Domains (4) summary

smart00255
Location:871 → 1007

TIR; Toll - interleukin 1 - resistance

cd00116
Location:32 → 252

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:65 → 88

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:600 → 667

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

166024119..166047325 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006528719.4 → XP_006528782.1 toll-like receptor 8 isoform X1

See identical proteins and their annotated locations for XP_006528782.1

Conserved Domains (5) summary

PRK15370
Location:47 → 231

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00255
Location:868 → 1004

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:141 → 717

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:62 → 85

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:701 → 762

LRR_8; Leucine rich repeat
XM_017318405.2 → XP_017173894.1 toll-like receptor 8 isoform X1

Conserved Domains (5) summary

PRK15370
Location:47 → 231

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00255
Location:868 → 1004

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:141 → 717

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:62 → 85

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:701 → 762

LRR_8; Leucine rich repeat