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    Cpm carboxypeptidase M [ Mus musculus (house mouse) ]

    Gene ID: 70574, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cpmprovided by MGI
    Official Full Name
    carboxypeptidase Mprovided by MGI
    Primary source
    MGI:MGI:1917824
    See related
    Ensembl:ENSMUSG00000020183 AllianceGenome:MGI:1917824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110060I01Rik; 5730456K23Rik; E030045M14Rik
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be located in plasma membrane and side of membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; embryo endoderm; genitourinary system; limb long bone; and sensory organ. Orthologous to human CPM (carboxypeptidase M). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 24.8), kidney adult (RPKM 7.5) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cpm in Genome Data Viewer
    Location:
    10 D2; 10 66.19 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (117465405..117523257)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (117629500..117687352)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32319 Neighboring gene predicted gene, 32365 Neighboring gene STARR-positive B cell enhancer mm9_chr10:117066381-117066682 Neighboring gene STARR-positive B cell enhancer ABC_E580 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:117089250-117089433 Neighboring gene STARR-positive B cell enhancer ABC_E9133 Neighboring gene STARR-positive B cell enhancer ABC_E8368 Neighboring gene predicted gene, 25709 Neighboring gene STARR-positive B cell enhancer ABC_E8369 Neighboring gene STARR-positive B cell enhancer ABC_E8869 Neighboring gene transformed mouse 3T3 cell double minute 2 Neighboring gene STARR-seq mESC enhancer starr_27991 Neighboring gene STARR-seq mESC enhancer starr_27993 Neighboring gene STARR-seq mESC enhancer starr_27994 Neighboring gene STARR-seq mESC enhancer starr_27995 Neighboring gene predicted gene, 53636

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interaction of angiotensin-converting enzyme (ACE) with membrane-bound carboxypeptidase M (CPM) - a new function of ACE. Sun X, et al. Biol Chem, 2008 Dec. PMID 18844448
    2. Multiple RNAs from the mouse carboxypeptidase M locus: functional RNAs or transcription noise? Guimarães AO, et al. BMC Mol Biol, 2009 Feb 8. PMID 19200403, Free PMC Article
    3. Developmental and sexual dimorphic atlas of the prenatal mouse external genitalia at the single-cell level. Amato CM, et al. Proc Natl Acad Sci U S A, 2021 Jun 22. PMID 34155146, Free PMC Article
    4. Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta. Mould A, et al. Genes Dev, 2012 Sep 15. PMID 22987638, Free PMC Article
    5. An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells. Ogaki S, et al. BMC Dev Biol, 2011 Mar 1. PMID 21362171, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118152

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase M
    NP_081744.1
    XP_006514153.1
    XP_036011899.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027468.1 → NP_081744.1  carboxypeptidase M precursor

      See identical proteins and their annotated locations for NP_081744.1

      Status: VALIDATED

      Source sequence(s)
      AC132139
      Consensus CDS
      CCDS48696.1
      UniProtKB/Swiss-Prot
      Q497S5, Q80V42, Q9CYH8
      Related
      ENSMUSP00000020399.6, ENSMUST00000020399.6
      Conserved Domains (2) summary
      cd11308
      Location:314 → 394
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cd03866
      Location:22 → 310
      M14_CPM; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase M subgroup

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      117465405..117523257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156006.1 → XP_036011899.1  carboxypeptidase M isoform X1

      UniProtKB/Swiss-Prot
      Q497S5, Q80V42, Q9CYH8
      Conserved Domains (2) summary
      cd11308
      Location:314 → 394
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cd03866
      Location:22 → 310
      M14_CPM; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase M subgroup

    2. XM_006514090.4 → XP_006514153.1  carboxypeptidase M isoform X2

      Conserved Domains (2) summary
      cd11308
      Location:193 → 273
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cl11393
      Location:1 → 189
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80V42.2 GenPept UniProtKB/Swiss-Prot:Q80V42

    Gene LinkOut

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