Gprc6a G protein-coupled receptor, family C, group 6, member A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gprc6aprovided by MGI
Official Full Name: G protein-coupled receptor, family C, group 6, member Aprovided by MGI
Primary source: MGI:MGI:2429498
See related: Ensembl:ENSMUSG00000019905 AllianceGenome:MGI:2429498
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables G protein-coupled receptor activity. Involved in regulation of testosterone biosynthetic process and response to amino acid. Is active in plasma membrane. Is expressed in several structures, including femur; liver; male reproductive gland or organ; musculature; and spleen. Orthologous to human GPRC6A (G protein-coupled receptor class C group 6 member A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 10 B3; 10 25.66 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (51490919..51507554, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (51614823..51631458, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extracellular Ca[2+] aggravates IgE-induced allergic reaction in mast cells through GPRC6A, a novel family C G-protein-coupled receptor.
Title: Extracellular Ca(2+) aggravates IgE-induced allergic reaction in mast cells through GPRC6A, a novel family C G-protein-coupled receptor.
Role of Nutrient-sensing Receptor GPRC6A in Regulating Colonic Group 3 Innate Lymphoid Cells and Inflamed Mucosal Healing.
Title: Role of Nutrient-sensing Receptor GPRC6A in Regulating Colonic Group 3 Innate Lymphoid Cells and Inflamed Mucosal Healing.
Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis.
Title: Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis.
Role of GPRC6A in Regulating Hepatic Energy Metabolism in Mice.
Title: Role of GPRC6A in Regulating Hepatic Energy Metabolism in Mice.
Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice.
Title: Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice.
If the regulatory functions of GPRC6A identified in mice translate to humans, and polymorphisms in GPRC6A are found to predict racial disparities in human diseases, GPRC6A may be a new gene target to predict, prevent, and treat MetS, PCa, and other disorders impacted by GPRC6A.
Title: GPRC6A: Jack of all metabolism (or master of none).
findings imply the possibility to ameliorate menopause-induced metabolic disorder by GPRC6A and adiponectin signaling
Title: Adiponectin receptor 1 resists the decline of serum osteocalcin and GPRC6A expression in ovariectomized mice.
GPCR6A activation by Alum leads to the initiation of innate inflammatory responses whereas it is an important signal for the limitation of adaptive immune responses induced by Alum, partially explained by B cell IL-10.
Title: GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses.
the loss of osteocalcin/Gprc6a signaling has a profound effect on beta-cell mass accrual during late pancreas morphogenesis
Title: Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a.
the GPRC6A receptor is involved in regulating exercise behaviour
Title: Enhanced voluntary wheel running in GPRC6A receptor knockout mice.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (9) 1 citation

General gene information

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Markers

D10Mit141 (e-PCR), detects polymorphism
- UniSTS:126041

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of testosterone biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of testosterone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to amino acid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to amino acid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: G-protein coupled receptor family C group 6 member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153071.1 → NP_694711.1 G-protein coupled receptor family C group 6 member A precursor

See identical proteins and their annotated locations for NP_694711.1

Status: PROVISIONAL

Source sequence(s)

AY101365

Consensus CDS

CCDS23834.1

UniProtKB/Swiss-Prot

Q5DK51, Q5DK52, Q8K4Z6

Related

ENSMUSP00000020062.4, ENSMUST00000020062.4

Conserved Domains (4) summary

cd06361
Location:37 → 506

PBP1_GPC6A_like; Ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor

pfam00003
Location:605 → 838

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:75 → 482

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:520 → 571

NCD3G; Nine Cysteines Domain of family 3 GPCR