Shroom1 shroom family member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Shroom1provided by MGI
Official Full Name: shroom family member 1provided by MGI
Primary source: MGI:MGI:1919024
See related: Ensembl:ENSMUSG00000018387 AllianceGenome:MGI:1919024
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Apx; Shrm1
Summary: Enables actin filament binding activity and myosin II binding activity. Involved in actin filament bundle assembly and cell morphogenesis. Predicted to be located in cytoplasm and microtubule. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Orthologous to human SHROOM1 (shroom family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver adult (RPKM 13.1), placenta adult (RPKM 5.8) and 21 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11 B1.3; 11 31.95 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (53347904..53358593)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (53457093..53467766)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suppression of SHROOM1 Improves In Vitro and In Vivo Gene Integration by Promoting Homology-Directed Repair.
Title: Suppression of SHROOM1 Improves In Vitro and In Vivo Gene Integration by Promoting Homology-Directed Repair.
The structure of Shrm domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm function, is reported.
Title: Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction.
Shroom localises exclusively to pulmonary smooth muscle cells and is attenuated in pulmonary arterial hypertension
Title: Shroom expression is attenuated in pulmonary arterial hypertension.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Shroom1 (e-PCR), detects polymorphism
- UniSTS:507223

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables myosin II binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament bundle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in apical junction complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: protein Shroom1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290789.1 → NP_001277718.1 protein Shroom1 isoform 2

See identical proteins and their annotated locations for NP_001277718.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the central coding region but maintains reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AK035462, AK134332, AL596095

Consensus CDS

CCDS70182.1

UniProtKB/TrEMBL

D3Z3D5

Related

ENSMUSP00000018531.6, ENSMUST00000018531.12

Conserved Domains (2) summary

pfam08687
Location:456 → 731

ASD2; Apx/Shroom domain ASD2

pfam08688
Location:140 → 239

ASD1; Apx/Shroom domain ASD1
NM_027917.3 → NP_082193.2 protein Shroom1 isoform 1

See identical proteins and their annotated locations for NP_082193.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK035462, AK134332, AL596095

Consensus CDS

CCDS24680.2

UniProtKB/Swiss-Prot

B1AQY5, B1AQY6, Q5SX79, Q5SX83, Q99JP8

UniProtKB/TrEMBL

D3Z3D5

Related

ENSMUSP00000104641.3, ENSMUST00000109013.9

Conserved Domains (2) summary

pfam08687
Location:519 → 794

ASD2; Apx/Shroom domain ASD2

pfam08688
Location:140 → 239

ASD1; Apx/Shroom domain ASD1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

53347904..53358593

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534259.5 → XP_006534322.1 protein Shroom1 isoform X1

UniProtKB/TrEMBL

D3Z3D5

Related

ENSMUSP00000090802.5, ENSMUST00000093114.5

Conserved Domains (2) summary

pfam08687
Location:519 → 772

ASD2; Apx/Shroom domain ASD2

pfam08688
Location:140 → 244

ASD1; Apx/Shroom domain ASD1