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    Snx11 sorting nexin 11 [ Mus musculus (house mouse) ]

    Gene ID: 74479, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx11provided by MGI
    Official Full Name
    sorting nexin 11provided by MGI
    Primary source
    MGI:MGI:1921729
    See related
    Ensembl:ENSMUSG00000020876 AllianceGenome:MGI:1921729
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933439F10Rik; A930041K09Rik
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in vesicle organization. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in endosome. Is expressed in central nervous system and olfactory epithelium. Orthologous to human SNX11 (sorting nexin 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 11.2), whole brain E14.5 (RPKM 11.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snx11 in Genome Data Viewer
    Location:
    11 D; 11 60.1 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96658372..96668538, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96767546..96777712, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11529 Neighboring gene src family associated phosphoprotein 1 Neighboring gene predicted gene, 38960 Neighboring gene STARR-seq mESC enhancer starr_30554 Neighboring gene STARR-seq mESC enhancer starr_30556 Neighboring gene STARR-seq mESC enhancer starr_30559 Neighboring gene STARR-seq mESC enhancer starr_30560 Neighboring gene STARR-positive B cell enhancer ABC_E1146 Neighboring gene STARR-seq mESC enhancer starr_30562 Neighboring gene STARR-seq mESC enhancer starr_30564 Neighboring gene STARR-seq mESC enhancer starr_30565 Neighboring gene STARR-positive B cell enhancer ABC_E9144 Neighboring gene STARR-positive B cell enhancer ABC_E9371 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene Neighboring gene chromobox 1 Neighboring gene nuclear factor, erythroid derived 2,-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sorting nexin 11 knockout mice exhibit enhanced thermosensing behaviour. Huang HL, et al. Genes Brain Behav, 2020 Jul. PMID 31730264
    2. Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Joyal JS, et al. Nat Med, 2014 Oct. PMID 25216639
    3. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sorting nexin 11 knockout mice exhibit enhanced thermosensing behaviour.
      Title: Sorting nexin 11 knockout mice exhibit enhanced thermosensing behaviour.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163389.1 → NP_001156861.1  sorting nexin-11

      See identical proteins and their annotated locations for NP_001156861.1

      Status: VALIDATED

      Source sequence(s)
      AK042409, AL607127, AV350384
      Consensus CDS
      CCDS25302.1
      UniProtKB/Swiss-Prot
      Q3V3A6, Q91WL6
      UniProtKB/TrEMBL
      Q9CUA3
      Related
      ENSMUSP00000103288.4, ENSMUST00000107661.10
      Conserved Domains (1) summary
      cd06898
      Location:18 → 129
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    2. NM_028965.4 → NP_083241.1  sorting nexin-11

      See identical proteins and their annotated locations for NP_083241.1

      Status: VALIDATED

      Source sequence(s)
      AK076332, AL607127, AV350384
      Consensus CDS
      CCDS25302.1
      UniProtKB/Swiss-Prot
      Q3V3A6, Q91WL6
      UniProtKB/TrEMBL
      Q9CUA3
      Related
      ENSMUSP00000021246.3, ENSMUST00000021246.9
      Conserved Domains (1) summary
      cd06898
      Location:18 → 129
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      96658372..96668538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249289.3 → XP_011247591.1  sorting nexin-11 isoform X1

      See identical proteins and their annotated locations for XP_011247591.1

      UniProtKB/Swiss-Prot
      Q3V3A6, Q91WL6
      UniProtKB/TrEMBL
      Q9CUA3
      Conserved Domains (1) summary
      cd06898
      Location:18 → 129
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    2. XM_006534375.4 → XP_006534438.1  sorting nexin-11 isoform X1

      See identical proteins and their annotated locations for XP_006534438.1

      UniProtKB/Swiss-Prot
      Q3V3A6, Q91WL6
      UniProtKB/TrEMBL
      Q9CUA3
      Conserved Domains (1) summary
      cd06898
      Location:18 → 129
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WL6.1 GenPept UniProtKB/Swiss-Prot:Q91WL6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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