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    Rnf212b ring finger protein 212B [ Mus musculus (house mouse) ]

    Gene ID: 102632837, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf212bprovided by MGI
    Official Full Name
    ring finger protein 212Bprovided by MGI
    Primary source
    MGI:MGI:5589964
    See related
    Ensembl:ENSMUSG00000112858 AllianceGenome:MGI:5589964
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm10332; Gm30805
    Summary
    Enables ubiquitin protein ligase activity. Involved in chiasma assembly and protein ubiquitination. Located in synaptonemal complex. Orthologous to human RNF212B (ring finger protein 212B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 2.1), testis adult (RPKM 2.0) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf212b in Genome Data Viewer
    Location:
    14; 14 C2- C3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55020798..55091567)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54783341..54854110)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CCAAT/enhancer binding protein epsilon Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 Neighboring gene STARR-seq mESC enhancer starr_36747 Neighboring gene predicted gene, 17772 Neighboring gene STARR-positive B cell enhancer ABC_E4110 Neighboring gene homeodomain leucine zipper-encoding gene Neighboring gene protein phosphatase 1, regulatory subunit 3E Neighboring gene BCL2-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse. Condezo YB, et al. Proc Natl Acad Sci U S A, 2024 Jun 18. PMID 38865271, Free PMC Article
    2. BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing. Yao X, et al. FASEB J, 2024 Jan. PMID 38085152
    3. Lineage-specific biology revealed by a finished genome assembly of the mouse. Church DM, et al. PLoS Biol, 2009 May 5. PMID 19468303, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse.
      Title: RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chiasma assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in homologous chromosome pairing at meiosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF212B; rING finger protein 212B
    Names
    RING finger protein C14orf164 homolog
    NP_001357828.1
    XP_006519928.1
    XP_006519930.1
    XP_011243591.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370899.1 → NP_001357828.1  E3 ubiquitin-protein ligase RNF212B

      Status: VALIDATED

      Source sequence(s)
      AC116591
      Consensus CDS
      CCDS88665.1
      UniProtKB/Swiss-Prot
      D3Z2T6, D3Z423
      Related
      ENSMUSP00000151344.2, ENSMUST00000218311.2
      Conserved Domains (2) summary
      cd16747
      Location:5 → 40
      RING-HC_RNF212B; RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins
      cl21462
      Location:93 → 124
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55020798..55091567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245289.3 → XP_011243591.1  rING finger protein 212B isoform X1

      See identical proteins and their annotated locations for XP_011243591.1

      UniProtKB/Swiss-Prot
      D3Z2T6, D3Z423
      Conserved Domains (2) summary
      cd16747
      Location:5 → 40
      RING-HC_RNF212B; RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins
      cl21462
      Location:93 → 124
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    2. XM_006519865.3 → XP_006519928.1  rING finger protein 212B isoform X1

      See identical proteins and their annotated locations for XP_006519928.1

      UniProtKB/Swiss-Prot
      D3Z2T6, D3Z423
      Conserved Domains (2) summary
      cd16747
      Location:5 → 40
      RING-HC_RNF212B; RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins
      cl21462
      Location:93 → 124
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    3. XM_006519867.4 → XP_006519930.1  rING finger protein 212B isoform X2

      See identical proteins and their annotated locations for XP_006519930.1

      Conserved Domains (2) summary
      cd16747
      Location:5 → 40
      RING-HC_RNF212B; RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins
      cl21462
      Location:93 → 124
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3Z423.1 GenPept UniProtKB/Swiss-Prot:D3Z423

    Gene LinkOut

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