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    Serpine3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 319433, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Serpine3provided by MGI
    Official Full Name
    serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3provided by MGI
    Primary source
    MGI:MGI:2442020
    See related
    Ensembl:ENSMUSG00000091155 AllianceGenome:MGI:2442020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E130113E03Rik
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Orthologous to human SERPINE3 (serpin family E member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 1.1), CNS E18 (RPKM 1.0) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Serpine3 in Genome Data Viewer
    Location:
    14 D1; 14 33.23 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (62900743..62929692)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (62663298..62692243)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 124, member A Neighboring gene predicted gene, 23816 Neighboring gene predicted gene, 25162 Neighboring gene 60S ribosomal protein L38 pseudogene Neighboring gene integrator complex subunit 6 Neighboring gene STARR-seq mESC enhancer starr_36903 Neighboring gene RIKEN cDNA 4931440J10 gene Neighboring gene STARR-positive B cell enhancer ABC_E756 Neighboring gene predicted gene, 35678 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7323 Neighboring gene predicted gene, 26536 Neighboring gene microRNA 8098 Neighboring gene WD repeat and FYVE domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Vision-related convergent gene losses reveal SERPINE3's unknown role in the eye. Indrischek H, et al. Elife, 2022 Jun 21. PMID 35727138, Free PMC Article
    2. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vision-related convergent gene losses reveal SERPINE3's unknown role in the eye.
      Title: Vision-related convergent gene losses reveal SERPINE3's unknown role in the eye.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serpin E3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199945.1 → NP_001186874.1  serpin E3 precursor

      Status: VALIDATED

      Source sequence(s)
      AK053602
      Consensus CDS
      CCDS49518.1
      UniProtKB/TrEMBL
      E9Q6A2
      Related
      ENSMUSP00000125769.2, ENSMUST00000171692.2
      Conserved Domains (1) summary
      pfam00079
      Location:33 → 399
      Serpin; Serpin (serine protease inhibitor)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      62900743..62929692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316054.3 → XP_017171543.1  serpin E3 isoform X1

      Conserved Domains (1) summary
      cl38926
      Location:20 → 388
      serpin; SERine Proteinase INhibitors (serpin) family
    Nucleotide Protein Strain
    Heading Accession and Version

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