Pick1 protein interacting with C kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pick1provided by MGI
Official Full Name: protein interacting with C kinase 1provided by MGI
Primary source: MGI:MGI:894645
See related: Ensembl:ENSMUSG00000068206 AllianceGenome:MGI:894645
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prkcabp
Summary: Enables protein kinase C binding activity and signaling receptor binding activity. Involved in receptor clustering. Acts upstream of or within protein targeting. Located in several cellular components, including Golgi apparatus; perinuclear region of cytoplasm; and postsynaptic density. Is expressed in brain; cerebellum Purkinje cell layer; cerebellum molecular layer; cerebral cortex ventricular layer; and cortical plate. Orthologous to human PICK1 (protein interacting with PRKCA 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 26.1), CNS E14 (RPKM 24.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.7 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (79113373..79133666)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (79229140..79249466)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment.
Title: Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment.
Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells.
Title: Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells.
Circulating ovarian hormones interact with protein interacting with C kinase (PICK1) within the medial prefrontal cortex to influence cocaine seeking in female mice.
Title: Circulating ovarian hormones interact with protein interacting with C kinase (PICK1) within the medial prefrontal cortex to influence cocaine seeking in female mice.
A vital role for PICK1 in the differential regulation of metabotropic glutamate receptor internalization and synaptic AMPA receptor endocytosis.
Title: A vital role for PICK1 in the differential regulation of metabotropic glutamate receptor internalization and synaptic AMPA receptor endocytosis.
Truncating PICK1 Variant Identified in Azoospermia Affected Mitochondrial Dysfunction in Knockout Mice.
Title: Truncating PICK1 Variant Identified in Azoospermia Affected Mitochondrial Dysfunction in Knockout Mice.
The M1 muscarinic acetylcholine receptor regulates the surface expression of the AMPA receptor subunit GluA2 via PICK1.
Title: The M1 muscarinic acetylcholine receptor regulates the surface expression of the AMPA receptor subunit GluA2 via PICK1.
PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.
Title: PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.
FSC231 can alleviate paclitaxel-induced neuralgia by inhibiting PICK1 and affecting related factors.
Title: FSC231 can alleviate paclitaxel-induced neuralgia by inhibiting PICK1 and affecting related factors.
PICK1 attenuates high glucose-induced pancreatic beta-cell death through the PI3K/Akt pathway and is negatively regulated by miR-139-5p.
Title: PICK1 attenuates high glucose-induced pancreatic β-cell death through the PI3K/Akt pathway and is negatively regulated by miR-139-5p.
These data support a novel interaction and model where PICK1 mediates Arc regulation of AMPARs particularly under depolarizing conditions.
Title: Arc/Arg3.1 has an activity-regulated interaction with PICK1 that results in altered spatial dynamics.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	ISO Inferred from Sequence Orthology more info
enables Arp2/3 complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables G protein-coupled glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables SNAP receptor activity	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables membrane curvature sensor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase C binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase C binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables protein kinase C binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to decreased oxygen levels	ISO Inferred from Sequence Orthology more info
involved_in cellular response to decreased oxygen levels	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendritic spine maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendritic spine organization	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in glial cell development	ISO Inferred from Sequence Orthology more info
involved_in glial cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic depression	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoamine transport	ISO Inferred from Sequence Orthology more info
involved_in monoamine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein targeting	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse structure or activity	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic early endosome	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic endocytic zone	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PRKCA-binding protein

Names: protein kinase C-alpha-binding protein; protein that interacts with C kinase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045558.1 → NP_001039023.1 PRKCA-binding protein

See identical proteins and their annotated locations for NP_001039023.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AI385692, AI893973, AK090155, BU698586

Consensus CDS

CCDS27635.1

UniProtKB/TrEMBL

E9PUZ5, Q80VC8

Related

ENSMUSP00000018295.8, ENSMUST00000018295.14

Conserved Domains (2) summary

cd07659
Location:146 → 360

BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1

smart00228
Location:19 → 99

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
NM_008837.3 → NP_032863.2 PRKCA-binding protein

See identical proteins and their annotated locations for NP_032863.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AI385692, AI893973, AK090155, AL591921, BU698586

Consensus CDS

CCDS27635.1

UniProtKB/TrEMBL

E9PUZ5, Q80VC8

Related

ENSMUSP00000128126.2, ENSMUST00000163571.8

Conserved Domains (2) summary

cd07659
Location:146 → 360

BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1

smart00228
Location:19 → 99

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2