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    Prss30 serine protease 30 [ Mus musculus (house mouse) ]

    Gene ID: 30943, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prss30provided by MGI
    Official Full Name
    serine protease 30provided by MGI
    Primary source
    MGI:MGI:1353645
    See related
    Ensembl:ENSMUSG00000024124 AllianceGenome:MGI:1353645
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Disp; Disp1; Tmprss8; 2010015P21Rik
    Summary
    Predicted to enable serine-type endopeptidase activity and sodium channel regulator activity. Predicted to be involved in proteolysis and sodium ion transport. Predicted to be located in plasma membrane and side of membrane. Predicted to be active in extracellular space. Is expressed in embryo; prostate gland; and smooth muscle tissue. Orthologous to human PRSS30P (serine protease 30, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 83.0), large intestine adult (RPKM 60.3) and 2 other tissues See more
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    Genomic context

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    See Prss30 in Genome Data Viewer
    Location:
    17 12.17 cM; 17 A3.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24191100..24199545, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23972126..23980571, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41545 Neighboring gene spermine binding protein Neighboring gene spermine binding protein-like Neighboring gene predicted gene, 41546 Neighboring gene serine protease 22 Neighboring gene predicted gene, 41547

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterisation of a novel murine intestinal serine protease, DISP. Shaw-Smith CJ, et al. Biochim Biophys Acta, 2000 Jan 31. PMID 10786627
    2. Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns. Wong GW, et al. J Biol Chem, 2004 Jan 23. PMID 14583634
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine-type peptidase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine protease 30
    Names
    distal intestinal serine protease
    protease, serine 30
    transmembrane protease, serine 8 (intestinal)
    transmembrane serine protease 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013921.3 → NP_038949.2  serine protease 30 precursor

      See identical proteins and their annotated locations for NP_038949.2

      Status: VALIDATED

      Source sequence(s)
      AC110262
      Consensus CDS
      CCDS28470.1
      UniProtKB/Swiss-Prot
      Q91XC4, Q9QYZ9
      Related
      ENSMUSP00000024936.4, ENSMUST00000024936.11
      Conserved Domains (1) summary
      cd00190
      Location:37 → 275
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24191100..24199545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524382.4 → XP_006524445.1  serine protease 30 isoform X3

      See identical proteins and their annotated locations for XP_006524445.1

      UniProtKB/Swiss-Prot
      Q91XC4, Q9QYZ9
      Related
      ENSMUSP00000157077.2, ENSMUST00000234765.2
      Conserved Domains (1) summary
      cd00190
      Location:37 → 275
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. XM_011246484.2 → XP_011244786.1  serine protease 30 isoform X2

      Conserved Domains (1) summary
      cd00190
      Location:74 → 296
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. XM_011246483.2 → XP_011244785.1  serine protease 30 isoform X1

      Conserved Domains (1) summary
      cd00190
      Location:74 → 312
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    4. XM_011246485.1 → XP_011244787.1  serine protease 30 isoform X4

      UniProtKB/TrEMBL
      D6REI2
      Related
      ENSMUSP00000117647.2, ENSMUST00000151448.8
      Conserved Domains (1) summary
      cd00190
      Location:74 → 213
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYZ9.2 GenPept UniProtKB/Swiss-Prot:Q9QYZ9

    Gene LinkOut

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