Muc21 mucin 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Muc21provided by MGI
Official Full Name: mucin 21provided by MGI
Primary source: MGI:MGI:3779983
See related: Ensembl:ENSMUSG00000090588 AllianceGenome:MGI:3779983
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm9573
Summary: Acts upstream of or within negative regulation of cell-cell adhesion and negative regulation of cell-substrate adhesion. Located in plasma membrane. Orthologous to human MUC21 (mucin 21, cell surface associated). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in genital fat pad adult (RPKM 1.8) and testis adult (RPKM 0.1) See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.7 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (35928815..35937529, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35617923..35626637, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mucin 21/epiglycanin modulates cell adhesion
Title: Mucin 21/epiglycanin modulates cell adhesion.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mucin-21

Names: epiglycanin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001244654.1 → NP_001231583.1 mucin-21 precursor

Status: VALIDATED

Source sequence(s)

CR974473

Consensus CDS

CCDS57077.1

UniProtKB/TrEMBL

F7C950

Related

ENSMUSP00000130987.3, ENSMUST00000164502.3

Conserved Domains (1) summary

pfam14654
Location:1518 → 1605

Epiglycanin_C; Mucin, catalytic, TM and cytoplasmic tail region