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    Cdc42bpg CDC42 binding protein kinase gamma [ Mus musculus (house mouse) ]

    Gene ID: 240505, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdc42bpgprovided by MGI
    Official Full Name
    CDC42 binding protein kinase gammaprovided by MGI
    Primary source
    MGI:MGI:2652845
    See related
    Ensembl:ENSMUSG00000024769 AllianceGenome:MGI:2652845
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MRCKgamma
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in actomyosin structure organization and protein phosphorylation. Predicted to be located in cell leading edge; centriolar satellite; and cytosol. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human CDC42BPG (CDC42 binding protein kinase gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 55.3), colon adult (RPKM 31.8) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdc42bpg in Genome Data Viewer
    Location:
    19 A; 19 4.43 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6356465..6375682)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6306253..6325653)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene 14963 Neighboring gene STARR-positive B cell enhancer ABC_E8732 Neighboring gene EH-domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_45427 Neighboring gene predicted gene, 52380 Neighboring gene STARR-positive B cell enhancer ABC_E5682 Neighboring gene STARR-positive B cell enhancer ABC_E11670 Neighboring gene STARR-positive B cell enhancer ABC_E3239 Neighboring gene STARR-positive B cell enhancer ABC_E11015 Neighboring gene multiple endocrine neoplasia 1 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene microRNA 6989

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model. Kwa MQ, et al. Cells, 2021 Apr 19. PMID 33921698, Free PMC Article
    2. Proteomic studies of a single CNS synapse type: the parallel fiber/purkinje cell synapse. Selimi F, et al. PLoS Biol, 2009 Apr 14. PMID 19402746, Free PMC Article
    3. Rebalancing gene haploinsufficiency in vivo by targeting chromatin. Fulcoli FG, et al. Nat Commun, 2016 Jun 3. PMID 27256596, Free PMC Article
    4. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    5. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MRCKalpha Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model.
      Title: MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model.
    2. MRCKgamma can modulate maturation of dendritic spines in cultured cortical neurons, and it is localized specifically to parallel fiber/Purkinje cell synapses in vivo.
      Title: Proteomic studies of a single CNS synapse type: the parallel fiber/purkinje cell synapse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell leading edge ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase MRCK gamma
    Names
    CDC42 binding protein kinase gamma (DMPK-like)
    DMPK-like gamma
    MRCK gamma
    myotonic dystrophy kinase-related CDC42-binding kinase gamma
    myotonic dystrophy protein kinase-like alpha
    myotonic dystrophy protein kinase-like gamma
    NP_001028514.1
    XP_036017481.1
    XP_036017482.1
    XP_036017483.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033342.1 → NP_001028514.1  serine/threonine-protein kinase MRCK gamma

      See identical proteins and their annotated locations for NP_001028514.1

      Status: VALIDATED

      Source sequence(s)
      AC127556
      Consensus CDS
      CCDS50365.1
      UniProtKB/Swiss-Prot
      Q80UW5
      Related
      ENSMUSP00000025681.8, ENSMUST00000025681.8
      Conserved Domains (7) summary
      pfam08826
      Location:743 → 798
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:71 → 337
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01243
      Location:937 → 1069
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69 → 399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:878 → 926
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1096 → 1359
      CNH; CNH domain
      pfam09728
      Location:452 → 774
      Taxilin; Myosin-like coiled-coil protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6356465..6375682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161588.1 → XP_036017481.1  serine/threonine-protein kinase MRCK gamma isoform X1

      Conserved Domains (5) summary
      cd01243
      Location:937 → 1069
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69 → 399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      TIGR02168
      Location:444 → 802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00780
      Location:1096 → 1359
      CNH; CNH domain
      cd20866
      Location:878 → 929
      C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins

    2. XM_036161589.1 → XP_036017482.1  serine/threonine-protein kinase MRCK gamma isoform X2

      Conserved Domains (5) summary
      cd01243
      Location:936 → 1068
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69 → 399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      TIGR02168
      Location:444 → 802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00780
      Location:1095 → 1358
      CNH; CNH domain
      cd20866
      Location:877 → 928
      C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins

    3. XM_036161590.1 → XP_036017483.1  serine/threonine-protein kinase MRCK gamma isoform X3

      Conserved Domains (4) summary
      cd01243
      Location:937 → 1069
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69 → 399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      TIGR02168
      Location:444 → 802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd20866
      Location:878 → 929
      C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80UW5.2 GenPept UniProtKB/Swiss-Prot:Q80UW5

    Gene LinkOut

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