Lpin3 lipin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lpin3provided by MGI
Official Full Name: lipin 3provided by MGI
Primary source: MGI:MGI:1891342
See related: Ensembl:ENSMUSG00000027412 AllianceGenome:MGI:1891342
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA4023; 9130206L11Rik
Summary: Enables phosphatidate phosphatase activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; positive regulation of transcription by RNA polymerase II; and triglyceride biosynthetic process. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; genitourinary system; gut; skin; and trachea. Orthologous to human LPIN3 (lipin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in adrenal adult (RPKM 11.4), large intestine adult (RPKM 11.0) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H2; 2 80.98 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (160722590..160747920)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (160880670..160906000)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1.
Title: Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1.
These data implicate lipin 2/3 as a control point for enterocyte phospholipid homeostasis and chylomicron biogenesis.
Title: Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis.
Data suggest that phosphorylation does not affect catalytic activity of lipin 3 or its ability to associate with phosphatidic acid in vitro; different polybasic domains in lipin 1 and lipin 3 are responsible for phospho-regulation on the former but not the latter enzyme.
Title: The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3.
Lipin-3 exhibits phosphatidate phosphatase type-1 (PAP1) activity, which has a key role in glycerolipid synthesis.
Title: Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234567

AV236139 (e-PCR)
- UniSTS:165231

MARC_23321-23322:1024689677:5 (e-PCR)
- UniSTS:268673

Lpin3 (e-PCR), detects polymorphism
- UniSTS:206987

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISA Inferred from Sequence Alignment more info	PubMed

General protein information

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Preferred Names: phosphatidate phosphatase LPIN3

NP_001186047.1

EC 3.1.3.4

NP_075021.1

EC 3.1.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199118.2 → NP_001186047.1 phosphatidate phosphatase LPIN3

See identical proteins and their annotated locations for NP_001186047.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL590389

Consensus CDS

CCDS16998.1

UniProtKB/Swiss-Prot

Q3TQ75, Q8C7R9, Q99PI4

UniProtKB/TrEMBL

A2A4B1, Q149B0

Related

ENSMUSP00000043053.7, ENSMUST00000040872.13

Conserved Domains (4) summary

COG5083
Location:1 → 816

SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]

pfam04571
Location:1 → 106

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:589 → 814

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:435 → 525

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
NM_022883.4 → NP_075021.1 phosphatidate phosphatase LPIN3

See identical proteins and their annotated locations for NP_075021.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL590389

Consensus CDS

CCDS16998.1

UniProtKB/Swiss-Prot

Q3TQ75, Q8C7R9, Q99PI4

UniProtKB/TrEMBL

A2A4B1, Q149B0

Related

ENSMUSP00000105082.3, ENSMUST00000109456.9

Conserved Domains (4) summary

COG5083
Location:1 → 816

SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]

pfam04571
Location:1 → 106

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:589 → 814

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:435 → 525

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain