Prrg4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prrg4provided by MGI
Official Full Name: proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)provided by MGI
Primary source: MGI:MGI:2442211
See related: Ensembl:ENSMUSG00000027171 AllianceGenome:MGI:2442211
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TMG4; 9930111I18Rik
Summary: Predicted to enable WW domain binding activity and serine-type endopeptidase activity. Predicted to be involved in blood coagulation. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment membrane and extracellular region. Predicted to be active in extracellular space and plasma membrane. Orthologous to human PRRG4 (proline rich and Gla domain 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in placenta adult (RPKM 2.9), bladder adult (RPKM 1.7) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E2; 2 54.98 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (104657374..104680216, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (104830741..104849872, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables WW domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in blood coagulation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transmembrane gamma-carboxyglutamic acid protein 4

Names: proline-rich Gla protein 4; proline-rich gamma-carboxyglutamic acid protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178695.5 → NP_848810.3 transmembrane gamma-carboxyglutamic acid protein 4 precursor

See identical proteins and their annotated locations for NP_848810.3

Status: VALIDATED

Source sequence(s)

AK035530, AK038703

Consensus CDS

CCDS16493.1

UniProtKB/Swiss-Prot

Q8BGN6, Q8BM25

UniProtKB/TrEMBL

Q3TLN5, Q4KL73

Related

ENSMUSP00000028593.5, ENSMUST00000028593.11

Conserved Domains (2) summary

pfam00594
Location:57 → 97

Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

cl15239
Location:78 → 178

PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

104657374..104680216 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250334.2 → XP_030106194.1 transmembrane gamma-carboxyglutamic acid protein 4 isoform X1

UniProtKB/Swiss-Prot

Q8BGN6, Q8BM25

UniProtKB/TrEMBL

Q3TLN5, Q4KL73

Conserved Domains (2) summary

pfam00594
Location:57 → 97

Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

cl15239
Location:78 → 178

PLDc_SF; Catalytic domain of phospholipase D superfamily proteins