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    She src homology 2 domain-containing transforming protein E [ Mus musculus (house mouse) ]

    Gene ID: 214547, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sheprovided by MGI
    Official Full Name
    src homology 2 domain-containing transforming protein Eprovided by MGI
    Primary source
    MGI:MGI:1099462
    See related
    Ensembl:ENSMUSG00000046280 AllianceGenome:MGI:1099462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9430022A14
    Summary
    Predicted to enable phosphotyrosine residue binding activity. Is expressed in embryo mesenchyme; endocardial lining; heart trabecula; and heart valve. Orthologous to human SHE (Src homology 2 domain containing E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 7.4), ovary adult (RPKM 2.5) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See She in Genome Data Viewer
    Location:
    3 F1; 3 39.19 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89738667..89766149)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89831370..89858846)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2Q family member 1 Neighboring gene STARR-seq mESC enhancer starr_08252 Neighboring gene STARR-seq mESC enhancer starr_08253 Neighboring gene STARR-positive B cell enhancer ABC_E2083 Neighboring gene STARR-seq mESC enhancer starr_08257 Neighboring gene predicted gene 8969 Neighboring gene STARR-positive B cell enhancer ABC_E9217 Neighboring gene STARR-positive B cell enhancer ABC_E4556 Neighboring gene interleukin 6 receptor, alpha Neighboring gene STARR-seq mESC enhancer starr_08265 Neighboring gene STARR-positive B cell enhancer ABC_E2670 Neighboring gene STARR-seq mESC enhancer starr_08266 Neighboring gene STARR-positive B cell enhancer ABC_E7921 Neighboring gene ATPase, class I, type 8B, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E7922

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. Oda T, et al. Oncogene, 1997 Sep. PMID 9315092
    2. Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Takase H, et al. Blood, 2012 Jul 26. PMID 22535667
    3. Endothelial Cyp26b1 restrains murine heart valve growth during development. Ahuja N, et al. Dev Biol, 2022 Jun. PMID 35364055
    4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130415

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    SH2 domain-containing adapter protein E
    Names
    Src homology 2 domain containing E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411269.1 → NP_001398198.1  SH2 domain-containing adapter protein E isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102392

    2. NM_172530.4 → NP_766118.3  SH2 domain-containing adapter protein E isoform 1

      See identical proteins and their annotated locations for NP_766118.3

      Status: VALIDATED

      Source sequence(s)
      AC102392
      Consensus CDS
      CCDS17518.1
      UniProtKB/Swiss-Prot
      Q3TZT0, Q8BSD5
      Related
      ENSMUSP00000059658.6, ENSMUST00000050401.6
      Conserved Domains (1) summary
      cd10391
      Location:391 → 488
      SH2_SHE; Src homology 2 domain found in SH2 domain-containing adapter protein E (SHE)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89738667..89766149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BSD5.1 GenPept UniProtKB/Swiss-Prot:Q8BSD5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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