Kcna10 potassium voltage-gated channel, shaker-related subfamily, member 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcna10provided by MGI
Official Full Name: potassium voltage-gated channel, shaker-related subfamily, member 10provided by MGI
Primary source: MGI:MGI:3037820
See related: Ensembl:ENSMUSG00000042861 AllianceGenome:MGI:3037820
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kcna8; Kv1.8; Gm1962
Summary: Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in several structures, including inner ear and skeletal muscle. Used to study vestibular disease. Orthologous to human KCNA10 (potassium voltage-gated channel subfamily A member 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 3 F2.3; 3 46.64 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (107090459..107103037)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (107183143..107195721)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kcna10 is expressed primarily in hair cells of the inner ear and null mutations cause significant vestibular/mild hearing dysfunction.
Title: A null mutation of mouse Kcna10 causes significant vestibular and mild hearing dysfunction.
Kcna10 is most strikingly expressed in the hair cells in late embryonic stage however, at adult stages, however, Kcna10 expression is no longer specific to hair cells.
Title: Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily A member 10

Names: cyclic GMP gated potassium channel; potassium voltage gated channel, shaker related subfamily, member 8; voltage-gated potassium channel subunit Kv1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081140.1 → NP_001074609.1 potassium voltage-gated channel subfamily A member 10

See identical proteins and their annotated locations for NP_001074609.1

Status: PROVISIONAL

Source sequence(s)

AC121825, AC132405

Consensus CDS

CCDS38587.1

UniProtKB/Swiss-Prot

B2RQA1, B2RXZ4

Related

ENSMUSP00000088118.6, ENSMUST00000055064.8

Conserved Domains (4) summary

smart00225
Location:88 → 171

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:267 → 467

Ion_trans; Ion transport protein

pfam02214
Location:88 → 179

BTB_2; BTB/POZ domain

pfam07885
Location:382 → 458

Ion_trans_2; Ion channel