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    Tpst1 protein-tyrosine sulfotransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 22021, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tpst1provided by MGI
    Official Full Name
    protein-tyrosine sulfotransferase 1provided by MGI
    Primary source
    MGI:MGI:1298231
    See related
    Ensembl:ENSMUSG00000034118 AllianceGenome:MGI:1298231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tango13a
    Summary
    Enables protein-tyrosine sulfotransferase activity. Involved in peptidyl-tyrosine sulfation and post-translational protein modification. Is active in Golgi lumen and trans-Golgi network. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human TPST1 (tyrosylprotein sulfotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 26.6), testis adult (RPKM 22.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tpst1 in Genome Data Viewer
    Location:
    5 G1.3; 5 68.53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (130102167..130164575)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (130073326..130135734)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40334 Neighboring gene calcitonin gene-related peptide-receptor component protein Neighboring gene STARR-positive B cell enhancer ABC_E3625 Neighboring gene STARR-positive B cell enhancer ABC_E1690 Neighboring gene predicted gene, 54305 Neighboring gene STARR-positive B cell enhancer ABC_E233 Neighboring gene potassium channel tetramerisation domain containing 7 Neighboring gene STARR-seq mESC enhancer starr_14469 Neighboring gene STARR-positive B cell enhancer ABC_E3626 Neighboring gene RAB guanine nucleotide exchange factor (GEF) 1 Neighboring gene STARR-seq mESC enhancer starr_14471 Neighboring gene NADH:ubiquinone oxidoreductase subunit A12, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reduced body weight and increased postimplantation fetal death in tyrosylprotein sulfotransferase-1-deficient mice. Ouyang YB, et al. J Biol Chem, 2002 Jun 28. PMID 11964405
    2. Salivary gland hypofunction in tyrosylprotein sulfotransferase-2 knockout mice is due to primary hypothyroidism. Westmuckett AD, et al. PLoS One, 2013. PMID 23951251, Free PMC Article
    3. Tyrosine sulfation is a trans-Golgi-specific protein modification. Baeuerle PA, et al. J Cell Biol, 1987 Dec. PMID 3121635, Free PMC Article
    4. Early postnatal pulmonary failure and primary hypothyroidism in mice with combined TPST-1 and TPST-2 deficiency. Westmuckett AD, et al. Gen Comp Endocrinol, 2008 Mar 1. PMID 18243191, Free PMC Article
    5. Tyrosylprotein sulfotransferase-2 expression is required for sulfation of RNase 9 and Mfge8 in vivo. Hoffhines AJ, et al. J Biol Chem, 2009 Jan 30. PMID 19047058, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results demonstrate the importance of protein-tyrosine sulfation for proper development of the retina and suggest different phenotypes resulting from elimination of TPST-1 or -2 may reflect differential expression patterns or levels of the enzymes.
      Title: Differential developmental deficits in retinal function in the absence of either protein tyrosine sulfotransferase-1 or -2.
    2. two genes identified in this analysis, PLEC1 and TPST1, reduced IL-6 production by macrophages
      Title: Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands.
    3. Data show that Tpst1/Tpst2 DKO leukocytes bound less P-selectin than wild type leukocytes despite equivalent surface expression of Psgl-1.
      Title: Tyrosine sulfation of native mouse Psgl-1 is required for optimal leukocyte rolling on P-selectin in vivo.
    4. These results indicate that protein-tyrosine sulfation by Tpst1/2 is essential for proper outer segment morphogenesis and synaptic function, but is not critical for overall retinal structure or synapse formation.
      Title: Lack of protein-tyrosine sulfation disrupts photoreceptor outer segment morphogenesis, retinal function and retinal anatomy.
    5. Tpst1 and Tpst2 are the only Tpst genes in mice, tyrosine sulfation is required for normal pulmonary function at birth, and TPST-2 is required for normal thyroid gland function.
      Title: Early postnatal pulmonary failure and primary hypothyroidism in mice with combined TPST-1 and TPST-2 deficiency.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-tyrosine sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-tyrosine sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-tyrosine sulfotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-tyrosine sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-tyrosine sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine sulfation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-translational protein modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in post-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi lumen ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein-tyrosine sulfotransferase 1
    Names
    TPST-1
    tyrosylprotein sulfotransferase 1
    NP_001123948.1
    NP_038865.1
    XP_006504481.1
    XP_036020889.1
    XP_036020890.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130476.2 → NP_001123948.1  protein-tyrosine sulfotransferase 1

      See identical proteins and their annotated locations for NP_001123948.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI183198, AK150753, CJ046784
      Consensus CDS
      CCDS39293.1
      UniProtKB/Swiss-Prot
      O70281
      UniProtKB/TrEMBL
      Q4FK50
      Related
      ENSMUSP00000035614.9, ENSMUST00000040721.9
      Conserved Domains (1) summary
      pfam13469
      Location:72 → 261
      Sulfotransfer_3; Sulfotransferase family

    2. NM_013837.2 → NP_038865.1  protein-tyrosine sulfotransferase 1

      See identical proteins and their annotated locations for NP_038865.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF038008, AI183198
      Consensus CDS
      CCDS39293.1
      UniProtKB/Swiss-Prot
      O70281
      UniProtKB/TrEMBL
      Q4FK50
      Related
      ENSMUSP00000112571.2, ENSMUST00000118993.8
      Conserved Domains (1) summary
      pfam13469
      Location:72 → 261
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      130102167..130164575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164996.1 → XP_036020889.1  protein-tyrosine sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O70281
      UniProtKB/TrEMBL
      Q4FK50
      Conserved Domains (1) summary
      pfam13469
      Location:72 → 261
      Sulfotransfer_3; Sulfotransferase family

    2. XM_036164997.1 → XP_036020890.1  protein-tyrosine sulfotransferase 1 isoform X2

      Conserved Domains (1) summary
      pfam13469
      Location:72 → 261
      Sulfotransfer_3; Sulfotransferase family

    3. XM_006504418.3 → XP_006504481.1  protein-tyrosine sulfotransferase 1 isoform X2

      Conserved Domains (1) summary
      pfam13469
      Location:72 → 261
      Sulfotransfer_3; Sulfotransferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70281.1 GenPept UniProtKB/Swiss-Prot:O70281

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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