Vgf VGF nerve growth factor inducible [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vgfprovided by MGI
Official Full Name: VGF nerve growth factor inducibleprovided by MGI
Primary source: MGI:MGI:1343180
See related: Ensembl:ENSMUSG00000037428 AllianceGenome:MGI:1343180
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1052
Summary: Enables neuropeptide hormone activity. Acts upstream of or within several processes, including insulin secretion; response to dietary excess; and response to insulin. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and neuronal cell body. Predicted to be active in extracellular space and glutamatergic synapse. Is expressed in brain and thalamus. Orthologous to human VGF (VGF nerve growth factor inducible). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 24.6), frontal lobe adult (RPKM 19.9) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.13 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137054156..137062205)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137025301..137033351)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis.
Title: Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis.
SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells.
Title: SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells.
Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease.
Title: Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease.
the roles of VGF using transgenic mice and its relevance to pathologies in major depressive disorder and schizophrenia, are discussed.
Title: VGF has Roles in the Pathogenesis of Major Depressive Disorder and Schizophrenia: Evidence from Transgenic Mouse Models.
Results indicate that the rapid onset antidepressant-like actions of ketamine require VGF to regulate TrkB/mTOR/BICC1 signaling and AMPA receptor GluA1 phosphorylation.
Title: Essential roles of neuropeptide VGF regulated TrkB/mTOR/BICC1 signaling and phosphorylation of AMPA receptor subunit GluA1 in the rapid antidepressant-like actions of ketamine in mice.
implicate VGF in the development of cerebellar granule cells via promoting MAPK signaling and motor function in the adult stage
Title: Impaired Cerebellar Development in Mice Overexpressing VGF.
Study demonstrates that VGF-overexpressing mice exhibit behavioral and morphological abnormalities that may be related to the mental illnesses such as schizophrenia and depression. These findings indicate that VGF may be implicated in the pathogenesis of several mental illnesses and in brain development.
Title: Behavioral abnormalities with disruption of brain structure in mice overexpressing VGF.
Upregulation of VGF may be implicated in the pathophysiology of schizophrenia.
Title: Sensorimotor gating deficits and effects of antipsychotics on the hyperactivity in VGF-overexpressing mice.
conclude that the metabolic profile of germline VGF knockout mice is largely the result of VGF ablation in embryonic CNS neurons
Title: Embryonic ablation of neuronal VGF increases energy expenditure and reduces body weight.
VGF neuropeptides promote oligodendrogenesis in vitro, whereas Snf2h cKO mice treated with full-length VGF-encoding adenoviruses removed the requirement of exercise for survival.
Title: Voluntary Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within generation of precursor metabolites and energy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within generation of precursor metabolites and energy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within insulin secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cAMP	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cold	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to dietary excess	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to dietary excess	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to insulin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sexual reproduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synaptic signaling via neuropeptide	IEA Inferred from Electronic Annotation more info
involved_in synaptic signaling via neuropeptide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neurosecretory protein VGF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039385.1 → NP_001034474.1 neurosecretory protein VGF precursor

See identical proteins and their annotated locations for NP_001034474.1

Status: VALIDATED

Source sequence(s)

AC147986, CX236774

Consensus CDS

CCDS19760.1

UniProtKB/Swiss-Prot

Q0VGU4

Related

ENSMUSP00000048273.9, ENSMUST00000041543.9

Conserved Domains (1) summary

PRK14086
Location:24 → 248

dnaA; chromosomal replication initiator protein DnaA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

137054156..137062205

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254624.2 → XP_030110484.1 neurosecretory protein VGF isoform X1

UniProtKB/Swiss-Prot

Q0VGU4

Conserved Domains (1) summary

PRK14086
Location:24 → 248

dnaA; chromosomal replication initiator protein DnaA
XM_006504438.3 → XP_006504501.1 neurosecretory protein VGF isoform X1

See identical proteins and their annotated locations for XP_006504501.1

UniProtKB/Swiss-Prot

Q0VGU4

Related

ENSMUSP00000140815.2, ENSMUST00000190827.7

Conserved Domains (1) summary

PRK14086
Location:24 → 248

dnaA; chromosomal replication initiator protein DnaA
XM_006504436.3 → XP_006504499.1 neurosecretory protein VGF isoform X1

See identical proteins and their annotated locations for XP_006504499.1

UniProtKB/Swiss-Prot

Q0VGU4

Conserved Domains (1) summary

PRK14086
Location:24 → 248

dnaA; chromosomal replication initiator protein DnaA
XM_006504434.3 → XP_006504497.1 neurosecretory protein VGF isoform X1

See identical proteins and their annotated locations for XP_006504497.1

UniProtKB/Swiss-Prot

Q0VGU4

Conserved Domains (1) summary

PRK14086
Location:24 → 248

dnaA; chromosomal replication initiator protein DnaA
XM_017320939.2 → XP_017176428.1 neurosecretory protein VGF isoform X1

UniProtKB/Swiss-Prot

Q0VGU4

Conserved Domains (1) summary

PRK14086
Location:24 → 248

dnaA; chromosomal replication initiator protein DnaA
XM_030254618.1 → XP_030110478.1 neurosecretory protein VGF isoform X1

UniProtKB/Swiss-Prot

Q0VGU4

Conserved Domains (1) summary

PRK14086
Location:24 → 248

dnaA; chromosomal replication initiator protein DnaA
XM_030254622.1 → XP_030110482.1 neurosecretory protein VGF isoform X1

UniProtKB/Swiss-Prot

Q0VGU4

Conserved Domains (1) summary

PRK14086
Location:24 → 248

dnaA; chromosomal replication initiator protein DnaA
XM_036165241.1 → XP_036021134.1 neurosecretory protein VGF isoform X1

UniProtKB/Swiss-Prot

Q0VGU4

Conserved Domains (1) summary

PRK14086
Location:24 → 248

dnaA; chromosomal replication initiator protein DnaA
XM_006504435.3 → XP_006504498.1 neurosecretory protein VGF isoform X1

See identical proteins and their annotated locations for XP_006504498.1

UniProtKB/Swiss-Prot

Q0VGU4

Conserved Domains (1) summary

PRK14086
Location:24 → 248

dnaA; chromosomal replication initiator protein DnaA
XM_030254621.2 → XP_030110481.1 neurosecretory protein VGF isoform X1

UniProtKB/Swiss-Prot

Q0VGU4

Conserved Domains (1) summary

PRK14086
Location:24 → 248

dnaA; chromosomal replication initiator protein DnaA
XM_017320938.2 → XP_017176427.1 neurosecretory protein VGF isoform X1

UniProtKB/Swiss-Prot

Q0VGU4

Conserved Domains (1) summary

PRK14086
Location:24 → 248

dnaA; chromosomal replication initiator protein DnaA