Cracr2a calcium release activated channel regulator 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cracr2aprovided by MGI
Official Full Name: calcium release activated channel regulator 2Aprovided by MGI
Primary source: MGI:MGI:2685919
See related: Ensembl:ENSMUSG00000061414 AllianceGenome:MGI:2685919
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm462; Gm1073; Efcab4b
Summary: Predicted to enable GTPase activity and calcium ion binding activity. Involved in T-helper 1 cell differentiation and positive regulation of JNK cascade. Acts upstream of or within positive regulation of calcium ion transport. Predicted to be located in several cellular components, including Golgi apparatus; Weibel-Palade body; and immunological synapse. Is expressed in several structures, including alimentary system; bladder; cerebellum; male reproductive gland or organ; and trigeminal nerve. Orthologous to human CRACR2A (calcium release activated channel regulator 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in colon adult (RPKM 2.8), lung adult (RPKM 2.7) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 62.39 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (127538299..127651197)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (127561062..127674234)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study demonstrates the requirement of CRACR2A-mediated TCR signaling in Th1 responses as well as pathogenic conversion of Th17 cells, which occurs at the site of inflammation
Title: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.
GTP binding and prenylation of CRACR2A were associated with its localization near the Golgi and its stability
Title: A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

D6Mit335 (e-PCR), detects polymorphism
- UniSTS:130889

D6Mit368 (e-PCR), detects polymorphism
- UniSTS:130922

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in T-helper 1 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in activation of store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info
involved_in activation of store-operated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in endosomal transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of calcium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of positive regulation of store-operated calcium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization	IEA Inferred from Electronic Annotation more info
involved_in response to histamine	ISO Inferred from Sequence Orthology more info
involved_in response to histamine	ISS Inferred from Sequence or Structural Similarity more info
involved_in store-operated calcium entry	ISO Inferred from Sequence Orthology more info
involved_in store-operated calcium entry	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in Weibel-Palade body	ISO Inferred from Sequence Orthology more info
located_in Weibel-Palade body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule organizing center	IEA Inferred from Electronic Annotation more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in vesicle	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: EF-hand calcium-binding domain-containing protein 4B

Names: EF-hand calcium binding domain 4B; ras-related protein Rab-46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033464.4 → NP_001028636.1 EF-hand calcium-binding domain-containing protein 4B isoform 2

See identical proteins and their annotated locations for NP_001028636.1

Status: VALIDATED

Source sequence(s)

AC173480

Consensus CDS

CCDS20566.1

UniProtKB/Swiss-Prot

Q3UP38

Related

ENSMUSP00000071494.5, ENSMUST00000071563.5

Conserved Domains (1) summary

pfam13499
Location:49 → 103

EF-hand_7; EF-hand domain pair
NM_001368877.1 → NP_001355806.1 EF-hand calcium-binding domain-containing protein 4B isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC127373, AC173480

Consensus CDS

CCDS90125.1

UniProtKB/Swiss-Prot

A0A1D5RLZ8, B9EKF2, Q3UP38

Related

ENSMUSP00000148569.2, ENSMUST00000212051.2

Conserved Domains (3) summary

PRK12309
Location:7 → 107

PRK12309; transaldolase

cd00154
Location:541 → 699

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

COG1196
Location:117 → 403

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

127538299..127651197

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506341.5 → XP_006506404.1 EF-hand calcium-binding domain-containing protein 4B isoform X1

See identical proteins and their annotated locations for XP_006506404.1

Conserved Domains (3) summary

PRK12309
Location:32 → 132

PRK12309; transaldolase

cd00154
Location:566 → 724

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

COG1196
Location:142 → 428

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_006506343.5 → XP_006506406.1 EF-hand calcium-binding domain-containing protein 4B isoform X2

Conserved Domains (3) summary

PRK12309
Location:20 → 120

PRK12309; transaldolase

cd00154
Location:554 → 712

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

COG1196
Location:130 → 416

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_006506351.5 → XP_006506414.1 EF-hand calcium-binding domain-containing protein 4B isoform X5

See identical proteins and their annotated locations for XP_006506414.1

Conserved Domains (3) summary

PRK12309
Location:32 → 132

PRK12309; transaldolase

COG4372
Location:135 → 355

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

PRK12704
Location:228 → 305

PRK12704; phosphodiesterase; Provisional
XM_036166263.1 → XP_036022156.1 EF-hand calcium-binding domain-containing protein 4B isoform X5

Conserved Domains (3) summary

PRK12309
Location:32 → 132

PRK12309; transaldolase

COG4372
Location:135 → 355

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

PRK12704
Location:228 → 305

PRK12704; phosphodiesterase; Provisional
XM_006506345.5 → XP_006506408.1 EF-hand calcium-binding domain-containing protein 4B isoform X3

Conserved Domains (3) summary

PRK12309
Location:32 → 132

PRK12309; transaldolase

cd00154
Location:566 → 664

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

COG1196
Location:142 → 428

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_006506346.5 → XP_006506409.1 EF-hand calcium-binding domain-containing protein 4B isoform X4

Conserved Domains (3) summary

PRK12309
Location:32 → 132

PRK12309; transaldolase

cd00154
Location:566 → 670

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

COG1196
Location:142 → 428

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_011241400.4 → XP_011239702.1 EF-hand calcium-binding domain-containing protein 4B isoform X1

See identical proteins and their annotated locations for XP_011239702.1

Conserved Domains (3) summary

PRK12309
Location:32 → 132

PRK12309; transaldolase

cd00154
Location:566 → 724

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

COG1196
Location:142 → 428

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]