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    Crebl2 cAMP responsive element binding protein-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 232430, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Crebl2provided by MGI
    Official Full Name
    cAMP responsive element binding protein-like 2provided by MGI
    Primary source
    MGI:MGI:1889385
    See related
    Ensembl:ENSMUSG00000032652 AllianceGenome:MGI:1889385
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230205M03
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including positive regulation of D-glucose import; positive regulation of macromolecule metabolic process; and protein stabilization. Located in nucleus. Orthologous to human CREBL2 (cAMP responsive element binding protein like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.4), cerebellum adult (RPKM 4.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Crebl2 in Genome Data Viewer
    Location:
    6 G1; 6 65.77 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (134807090..134835894)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (134830127..134880580)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 16 Neighboring gene STARR-seq mESC enhancer starr_17547 Neighboring gene predicted gene, 36328 Neighboring gene RIKEN cDNA 1700055D16 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:134742531-134742832 Neighboring gene STARR-positive B cell enhancer ABC_E3688 Neighboring gene predicted gene, 53343 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:134779903-134780086 Neighboring gene G protein-coupled receptor 19 Neighboring gene RIKEN cDNA 2810454H06 gene Neighboring gene CRISPRi-validated cis-regulatory element for Cdkn1b and Gpr19 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:134848417-134848526 Neighboring gene predicted gene, 53344

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Parathyroid hormone receptor-1 signaling aggravates hepatic fibrosis through upregulating cAMP response element-binding protein-like 2. Hong T, et al. Hepatology, 2023 Dec 1. PMID 36939197
    2. CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes. Ma X, et al. Biochem J, 2011 Oct 1. PMID 21728997
    3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Parathyroid hormone receptor-1 signaling aggravates hepatic fibrosis through upregulating cAMP response element-binding protein-like 2.
      Title: Parathyroid hormone receptor-1 signaling aggravates hepatic fibrosis through upregulating cAMP response element-binding protein-like 2.
    2. Results of the present study indicate that CREBL2 plays a critical role in adipogenesis and lipogenesis via interaction with CREB.
      Title: CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130380, MGC130381

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of D-glucose import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cAMP-responsive element-binding protein-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177687.3 → NP_808355.1  cAMP-responsive element-binding protein-like 2

      See identical proteins and their annotated locations for NP_808355.1

      Status: PROVISIONAL

      Source sequence(s)
      AK045467
      Consensus CDS
      CCDS20640.1
      UniProtKB/TrEMBL
      A0A0R4J0D8
      Related
      ENSMUSP00000035304.6, ENSMUST00000046303.12
      Conserved Domains (1) summary
      cd14709
      Location:25 → 80
      bZIP_CREBL2; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      134807090..134835894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241329.4 → XP_011239631.2  cAMP-responsive element-binding protein-like 2 isoform X1

      UniProtKB/TrEMBL
      A0A0R4J0D8
      Conserved Domains (1) summary
      cd14709
      Location:25 → 80
      bZIP_CREBL2; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain

    2. XM_036166087.1 → XP_036021980.1  cAMP-responsive element-binding protein-like 2 isoform X2

      Conserved Domains (1) summary
      cd14709
      Location:21 → 76
      bZIP_CREBL2; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32M00.1 GenPept UniProtKB/Swiss-Prot:Q32M00

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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