Tmem86a transmembrane protein 86A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem86aprovided by MGI
Official Full Name: transmembrane protein 86Aprovided by MGI
Primary source: MGI:MGI:1915143
See related: Ensembl:ENSMUSG00000010307 AllianceGenome:MGI:1915143
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810054O13Rik
Summary: Enables alkenylglycerophosphocholine hydrolase activity. Predicted to be involved in lipid metabolic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including brain; gut; orbito-sphenoid; retina; and submandibular gland primordium. Orthologous to human TMEM86A (transmembrane protein 86A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in ovary adult (RPKM 385.9), duodenum adult (RPKM 94.2) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 30.68 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (46700388..46704524)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (47050640..47054776)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages.
Title: Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages.
Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism.
Title: Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

AI414959 (e-PCR)
- UniSTS:159646

AW742698 (e-PCR)
- UniSTS:208119

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alkenylglycerophosphocholine hydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alkenylglycerophosphocholine hydrolase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: lysoplasmalogenase TMEM86A

Names: lysoplasmalogenase-like protein TMEM86A

NP_080712.1

EC 3.3.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.