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    Fam76b family with sequence similarity 76, member B [ Mus musculus (house mouse) ]

    Gene ID: 72826, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fam76bprovided by MGI
    Official Full Name
    family with sequence similarity 76, member Bprovided by MGI
    Primary source
    MGI:MGI:1920076
    See related
    Ensembl:ENSMUSG00000037808 AllianceGenome:MGI:1920076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810485I05Rik
    Summary
    Predicted to be active in nuclear speck. Is expressed in esophagus and heart ventricle. Orthologous to human FAM76B (family with sequence similarity 76 member B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 10.9), whole brain E14.5 (RPKM 9.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam76b in Genome Data Viewer
    Location:
    9 A1; 9 3.51 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (13738490..13766033)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (13827194..13854687)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39291 Neighboring gene predicted gene, 53498 Neighboring gene myotubularin related protein 2 Neighboring gene STARR-seq mESC enhancer starr_23340 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:13631030-13631139 Neighboring gene STARR-positive B cell enhancer ABC_E3815 Neighboring gene STARR-positive B cell enhancer ABC_E363 Neighboring gene centrosomal protein 57 Neighboring gene peptidylprolyl isomerase B pseudogene Neighboring gene STARR-seq mESC enhancer starr_23341 Neighboring gene RIKEN cDNA 1700019J19 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FAM76B regulates PI3K/Akt/NF-κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA. Wang J, et al. Cell Mol Life Sci, 2024 Feb 29. PMID 38421448, Free PMC Article
    2. FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1. Wang D, et al. Elife, 2023 Aug 10. PMID 37643469, Free PMC Article
    3. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in mRNA stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM76B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358259.2 → NP_001345188.1  protein FAM76B isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT010488
      Conserved Domains (1) summary
      pfam16046
      Location:6 → 327
      FAM76; FAM76 protein

    2. NM_176836.5 → NP_789806.1  protein FAM76B isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT010488
      Consensus CDS
      CCDS22819.1
      UniProtKB/Swiss-Prot
      Q3UMA6, Q80XP8, Q80YR1, Q8CI69
      Related
      ENSMUSP00000062642.6, ENSMUST00000059579.12
      Conserved Domains (1) summary
      pfam16046
      Location:6 → 328
      FAM76; FAM76 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      13738490..13766033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155320.1 → XP_036011213.1  protein FAM76B isoform X1

      Conserved Domains (1) summary
      pfam16046
      Location:6 → 313
      FAM76; FAM76 protein

    2. XM_030244637.1 → XP_030100497.1  protein FAM76B isoform X3

      Conserved Domains (1) summary
      pfam16046
      Location:16 → 222
      FAM76; FAM76 protein

    3. XM_011242612.4 → XP_011240914.1  protein FAM76B isoform X2

      Conserved Domains (1) summary
      pfam16046
      Location:6 → 310
      FAM76; FAM76 protein

    RNA

    1. XR_004935577.1 RNA Sequence

    2. XR_004935578.1 RNA Sequence

    3. XR_001779022.2 RNA Sequence

      Related
      ENSMUST00000156680.2

    4. XR_003948022.1 RNA Sequence

    5. XR_004935576.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80XP8.1 GenPept UniProtKB/Swiss-Prot:Q80XP8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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