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    Cntn5 contactin 5 [ Mus musculus (house mouse) ]

    Gene ID: 244682, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cntn5provided by MGI
    Official Full Name
    contactin 5provided by MGI
    Primary source
    MGI:MGI:3042287
    See related
    Ensembl:ENSMUSG00000039488 AllianceGenome:MGI:3042287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NB-2; Gm507; 6720426O10Rik; A830025P08Rik
    Summary
    Predicted to enable cell-cell adhesion mediator activity. Involved in presynapse assembly. Acts upstream of or within sensory perception of sound. Is active in GABA-ergic synapse and presynaptic membrane. Is expressed in central nervous system. Orthologous to human CNTN5 (contactin 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 1.7), whole brain E14.5 (RPKM 0.8) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cntn5 in Genome Data Viewer
    Location:
    9 A1; 9 2.46 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (9627928..10904992, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (9634223..10904775, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23268 Neighboring gene STARR-seq mESC enhancer starr_23269 Neighboring gene protein cornichon homolog 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23270 Neighboring gene predicted gene, 46102 Neighboring gene STARR-seq mESC enhancer starr_23272 Neighboring gene STARR-seq mESC enhancer starr_23273 Neighboring gene microRNA 6237 Neighboring gene STARR-seq mESC enhancer starr_23275 Neighboring gene STARR-seq mESC enhancer starr_23276 Neighboring gene STARR-seq mESC enhancer starr_23277 Neighboring gene predicted gene, 39289 Neighboring gene STARR-seq mESC enhancer starr_23278 Neighboring gene STARR-seq mESC enhancer starr_23281 Neighboring gene STARR-seq mESC enhancer starr_23283 Neighboring gene STARR-seq mESC enhancer starr_23284 Neighboring gene predicted gene, 57548 Neighboring gene STARR-seq mESC enhancer starr_23285 Neighboring gene STARR-seq mESC enhancer starr_23286 Neighboring gene CD2-associated protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_23287 Neighboring gene predicted gene, 32710 Neighboring gene STARR-seq mESC enhancer starr_23288 Neighboring gene STARR-seq mESC enhancer starr_23289 Neighboring gene STARR-seq mESC enhancer starr_23290 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23291 Neighboring gene STARR-seq mESC enhancer starr_23292 Neighboring gene RAB11 family interacting protein 5 (class I) pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Unexpected phenotypic effects of a transgene integration causing a knockout of the endogenous Contactin-5 gene in mice. Smirnov AV, et al. Transgenic Res, 2018 Feb. PMID 29264679
    2. Deficiency of neural recognition molecule NB-2 affects the development of glutamatergic auditory pathways from the ventral cochlear nucleus to the superior olivary complex in mouse. Toyoshima M, et al. Dev Biol, 2009 Dec 15. PMID 19818338
    3. Aberrant responses to acoustic stimuli in mice deficient for neural recognition molecule NB-2. Li H, et al. Eur J Neurosci, 2003 Mar. PMID 12653969
    4. A cis-complex of NB-2/contactin-5 with amyloid precursor-like protein 1 is localized on the presynaptic membrane. Shimoda Y, et al. Neurosci Lett, 2012 Feb 29. PMID 22285261
    5. Structural abnormalities in the primary somatosensory cortex and a normal behavioral profile in Contactin-5 deficient mice. Kleijer KTE, et al. Cell Adh Migr, 2018 Jan 2. PMID 28346043, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. demonstrate a selective role of Cntn5 in development of the cerebral cortex without overt behavioral phenotypes
      Title: Structural abnormalities in the primary somatosensory cortex and a normal behavioral profile in Contactin-5 deficient mice.
    2. These findings link Cntn5 deficiency to obesity and hypertension
      Title: Unexpected phenotypic effects of a transgene integration causing a knockout of the endogenous Contactin-5 gene in mice.
    3. Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system
      Title: Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.
    4. The results of this study indicated that the Cntn5 are exploited for circuit formation and connectivity in early development and for synaptic maintenance during adulthood. Subtle alterations in the formation of the thalamocortical circuit
      Title: Contactin-5 expression during development and wiring of the thalamocortical system.
    5. findings demonstrated that NB-2 interacts with APLP and that both NB-2 and APLP1 are localized at presynaptic sites, suggesting that NB-2 associates with APLP1 in a cis manner on the presynaptic membrane
      Title: A cis-complex of NB-2/contactin-5 with amyloid precursor-like protein 1 is localized on the presynaptic membrane.
    6. NB-2 deficiency causes a deficit in synapse formation and then induces apoptosis in MNTB and VCN neurons, affecting auditory brainstem function
      Title: Deficiency of neural recognition molecule NB-2 affects the development of glutamatergic auditory pathways from the ventral cochlear nucleus to the superior olivary complex in mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in presynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic membrane IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    contactin-5
    Names
    neural recognition molecule NB-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033359.2 → NP_001028531.2  contactin-5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three alternate in-frame exons in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC118029, AK162856, CT033779
      Consensus CDS
      CCDS52721.1
      UniProtKB/TrEMBL
      E9PYK7, Q3TRE5
      Related
      ENSMUSP00000124214.2, ENSMUST00000162484.8
      Conserved Domains (5) summary
      cd04969
      Location:290 → 362
      Ig5_Contactin_like; Fifth Ig domain of contactin
      smart00410
      Location:18 → 72
      IG_like; Immunoglobulin like
      cd00063
      Location:465 → 562
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:274 → 362
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:94 → 181
      Ig; Immunoglobulin domain

    2. NM_001170787.1 → NP_001164258.1  contactin-5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001164258.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102350, AC107635, AC113470, AC118029, AC153417, AC154645, AC154651, CT033779
      Consensus CDS
      CCDS52722.1
      UniProtKB/Swiss-Prot
      E0CYC2, P68500
      Related
      ENSMUSP00000124327.2, ENSMUST00000160216.8
      Conserved Domains (4) summary
      cd00063
      Location:670 → 767
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cd04969
      Location:479 → 567
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      9627928..10904992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154952.1 → XP_036010845.1  contactin-5 isoform X6

      Conserved Domains (4) summary
      cd00063
      Location:670 → 767
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cd04969
      Location:479 → 567
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    2. XM_036154939.1 → XP_036010832.1  contactin-5 isoform X2

      Conserved Domains (6) summary
      cd00063
      Location:1006 → 1103
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00552
      Location:243 → 288
      IN_DBD_C; Integrase DNA binding domain
      pfam00665
      Location:78 → 172
      rve; Integrase core domain
      pfam02022
      Location:26 → 62
      Integrase_Zn; Integrase Zinc binding domain
      cd00096
      Location:406 → 410
      Ig; Ig strand A [structural motif]
      cl11960
      Location:404 → 499
      Ig; Immunoglobulin domain

    3. XM_036154954.1 → XP_036010847.1  contactin-5 isoform X8

      Conserved Domains (4) summary
      cd00063
      Location:602 → 699
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cd04969
      Location:411 → 499
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    4. XM_006509867.5 → XP_006509930.1  contactin-5 isoform X4

      See identical proteins and their annotated locations for XP_006509930.1

      Conserved Domains (3) summary
      cd00063
      Location:699 → 796
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    5. XM_036154953.1 → XP_036010846.1  contactin-5 isoform X8

      Conserved Domains (4) summary
      cd00063
      Location:602 → 699
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cd04969
      Location:411 → 499
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    6. XM_006509873.5 → XP_006509936.1  contactin-5 isoform X7

      Conserved Domains (2) summary
      cd00063
      Location:631 → 728
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:97 → 190
      Ig; Immunoglobulin domain

    7. XM_006509872.5 → XP_006509935.1  contactin-5 isoform X5

      See identical proteins and their annotated locations for XP_006509935.1

      UniProtKB/Swiss-Prot
      E0CYC2, P68500
      Conserved Domains (4) summary
      cd00063
      Location:670 → 767
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cd04969
      Location:479 → 567
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    8. XM_006509866.5 → XP_006509929.1  contactin-5 isoform X4

      See identical proteins and their annotated locations for XP_006509929.1

      Conserved Domains (3) summary
      cd00063
      Location:699 → 796
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    9. XM_036154968.1 → XP_036010861.1  contactin-5 isoform X12

      UniProtKB/TrEMBL
      Q3TRE5
      Conserved Domains (4) summary
      cd00063
      Location:388 → 485
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:17 → 22
      Ig; Ig strand A [structural motif]
      cd04969
      Location:197 → 285
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:17 → 104
      Ig; Immunoglobulin domain

    10. XM_036154967.1 → XP_036010860.1  contactin-5 isoform X11

      UniProtKB/TrEMBL
      Q3TRE5
      Conserved Domains (3) summary
      cd00063
      Location:417 → 514
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:17 → 22
      Ig; Ig strand A [structural motif]
      cl11960
      Location:17 → 104
      Ig; Immunoglobulin domain

    11. XM_036154961.1 → XP_036010854.1  contactin-5 isoform X10

      UniProtKB/TrEMBL
      Q3TRE5
      Conserved Domains (4) summary
      cd00063
      Location:456 → 553
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:85 → 90
      Ig; Ig strand A [structural motif]
      cd04969
      Location:265 → 353
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:85 → 172
      Ig; Immunoglobulin domain

    12. XM_036154956.1 → XP_036010849.1  contactin-5 isoform X9

      UniProtKB/TrEMBL
      Q3TRE5
      Conserved Domains (3) summary
      cd00063
      Location:485 → 582
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:85 → 90
      Ig; Ig strand A [structural motif]
      cl11960
      Location:85 → 172
      Ig; Immunoglobulin domain

    13. XM_036154945.1 → XP_036010838.1  contactin-5 isoform X5

      UniProtKB/Swiss-Prot
      E0CYC2, P68500
      Conserved Domains (4) summary
      cd00063
      Location:670 → 767
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cd04969
      Location:479 → 567
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    14. XM_036154941.1 → XP_036010834.1  contactin-5 isoform X4

      Conserved Domains (3) summary
      cd00063
      Location:699 → 796
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    15. XM_036154963.1 → XP_036010856.1  contactin-5 isoform X10

      UniProtKB/TrEMBL
      Q3TRE5
      Conserved Domains (4) summary
      cd00063
      Location:456 → 553
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:85 → 90
      Ig; Ig strand A [structural motif]
      cd04969
      Location:265 → 353
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:85 → 172
      Ig; Immunoglobulin domain

    16. XM_036154947.1 → XP_036010840.1  contactin-5 isoform X5

      UniProtKB/Swiss-Prot
      E0CYC2, P68500
      Conserved Domains (4) summary
      cd00063
      Location:670 → 767
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cd04969
      Location:479 → 567
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    17. XM_036154942.1 → XP_036010835.1  contactin-5 isoform X4

      Conserved Domains (3) summary
      cd00063
      Location:699 → 796
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    18. XM_036154965.1 → XP_036010858.1  contactin-5 isoform X10

      UniProtKB/TrEMBL
      Q3TRE5
      Conserved Domains (4) summary
      cd00063
      Location:456 → 553
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:85 → 90
      Ig; Ig strand A [structural motif]
      cd04969
      Location:265 → 353
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:85 → 172
      Ig; Immunoglobulin domain

    19. XM_036154962.1 → XP_036010855.1  contactin-5 isoform X10

      UniProtKB/TrEMBL
      Q3TRE5
      Conserved Domains (4) summary
      cd00063
      Location:456 → 553
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:85 → 90
      Ig; Ig strand A [structural motif]
      cd04969
      Location:265 → 353
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:85 → 172
      Ig; Immunoglobulin domain

    20. XM_036154957.1 → XP_036010850.1  contactin-5 isoform X9

      UniProtKB/TrEMBL
      Q3TRE5
      Conserved Domains (3) summary
      cd00063
      Location:485 → 582
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:85 → 90
      Ig; Ig strand A [structural motif]
      cl11960
      Location:85 → 172
      Ig; Immunoglobulin domain

    21. XM_036154949.1 → XP_036010842.1  contactin-5 isoform X5

      UniProtKB/Swiss-Prot
      E0CYC2, P68500
      Conserved Domains (4) summary
      cd00063
      Location:670 → 767
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cd04969
      Location:479 → 567
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    22. XM_011242366.3 → XP_011240668.1  contactin-5 isoform X4

      See identical proteins and their annotated locations for XP_011240668.1

      Conserved Domains (3) summary
      cd00063
      Location:699 → 796
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    23. XM_036154943.1 → XP_036010836.1  contactin-5 isoform X4

      Conserved Domains (3) summary
      cd00063
      Location:699 → 796
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    24. XM_036154955.1 → XP_036010848.1  contactin-5 isoform X8

      Conserved Domains (4) summary
      cd00063
      Location:602 → 699
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cd04969
      Location:411 → 499
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    25. XM_036154948.1 → XP_036010841.1  contactin-5 isoform X5

      UniProtKB/Swiss-Prot
      E0CYC2, P68500
      Conserved Domains (4) summary
      cd00063
      Location:670 → 767
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cd04969
      Location:479 → 567
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    26. XM_006509869.4 → XP_006509932.1  contactin-5 isoform X4

      See identical proteins and their annotated locations for XP_006509932.1

      Conserved Domains (3) summary
      cd00063
      Location:699 → 796
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    27. XM_036154966.1 → XP_036010859.1  contactin-5 isoform X10

      UniProtKB/TrEMBL
      Q3TRE5
      Conserved Domains (4) summary
      cd00063
      Location:456 → 553
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:85 → 90
      Ig; Ig strand A [structural motif]
      cd04969
      Location:265 → 353
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:85 → 172
      Ig; Immunoglobulin domain

    28. XM_036154959.1 → XP_036010852.1  contactin-5 isoform X9

      UniProtKB/TrEMBL
      Q3TRE5
      Conserved Domains (3) summary
      cd00063
      Location:485 → 582
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:85 → 90
      Ig; Ig strand A [structural motif]
      cl11960
      Location:85 → 172
      Ig; Immunoglobulin domain

    29. XM_036154944.1 → XP_036010837.1  contactin-5 isoform X4

      Conserved Domains (3) summary
      cd00063
      Location:699 → 796
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    30. XM_036154946.1 → XP_036010839.1  contactin-5 isoform X5

      UniProtKB/Swiss-Prot
      E0CYC2, P68500
      Conserved Domains (4) summary
      cd00063
      Location:670 → 767
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cd04969
      Location:479 → 567
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    31. XM_006509868.3 → XP_006509931.1  contactin-5 isoform X4

      See identical proteins and their annotated locations for XP_006509931.1

      Conserved Domains (3) summary
      cd00063
      Location:699 → 796
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    32. XM_036154964.1 → XP_036010857.1  contactin-5 isoform X10

      UniProtKB/TrEMBL
      Q3TRE5
      Conserved Domains (4) summary
      cd00063
      Location:456 → 553
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:85 → 90
      Ig; Ig strand A [structural motif]
      cd04969
      Location:265 → 353
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:85 → 172
      Ig; Immunoglobulin domain

    33. XM_036154958.1 → XP_036010851.1  contactin-5 isoform X9

      UniProtKB/TrEMBL
      Q3TRE5
      Conserved Domains (3) summary
      cd00063
      Location:485 → 582
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:85 → 90
      Ig; Ig strand A [structural motif]
      cl11960
      Location:85 → 172
      Ig; Immunoglobulin domain

    34. XM_036154951.1 → XP_036010844.1  contactin-5 isoform X5

      UniProtKB/Swiss-Prot
      E0CYC2, P68500
      Conserved Domains (4) summary
      cd00063
      Location:670 → 767
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cd04969
      Location:479 → 567
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    35. XM_036154950.1 → XP_036010843.1  contactin-5 isoform X5

      UniProtKB/Swiss-Prot
      E0CYC2, P68500
      Conserved Domains (4) summary
      cd00063
      Location:670 → 767
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:99 → 103
      Ig; Ig strand A [structural motif]
      cd04969
      Location:479 → 567
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:97 → 192
      Ig; Immunoglobulin domain

    36. XM_036154940.1 → XP_036010833.1  contactin-5 isoform X3

      Conserved Domains (7) summary
      cd00063
      Location:977 → 1074
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00552
      Location:243 → 288
      IN_DBD_C; Integrase DNA binding domain
      pfam00665
      Location:78 → 172
      rve; Integrase core domain
      pfam02022
      Location:26 → 62
      Integrase_Zn; Integrase Zinc binding domain
      cd00096
      Location:406 → 410
      Ig; Ig strand A [structural motif]
      cd04969
      Location:786 → 874
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:404 → 499
      Ig; Immunoglobulin domain

    37. XM_036154938.1 → XP_036010831.1  contactin-5 isoform X1

      Conserved Domains (6) summary
      cd00063
      Location:1006 → 1103
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00552
      Location:243 → 288
      IN_DBD_C; Integrase DNA binding domain
      pfam00665
      Location:78 → 172
      rve; Integrase core domain
      pfam02022
      Location:26 → 62
      Integrase_Zn; Integrase Zinc binding domain
      cd00096
      Location:406 → 410
      Ig; Ig strand A [structural motif]
      cl11960
      Location:404 → 499
      Ig; Immunoglobulin domain

    38. XM_036154960.1 → XP_036010853.1  contactin-5 isoform X9

      UniProtKB/TrEMBL
      Q3TRE5
      Conserved Domains (3) summary
      cd00063
      Location:485 → 582
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:85 → 90
      Ig; Ig strand A [structural motif]
      cl11960
      Location:85 → 172
      Ig; Immunoglobulin domain

    RNA

    1. XR_004935436.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P68500.2 GenPept UniProtKB/Swiss-Prot:P68500

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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