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    Zfp622 zinc finger protein 622 [ Mus musculus (house mouse) ]

    Gene ID: 52521, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Zfp622provided by MGI
    Official Full Name
    zinc finger protein 622provided by MGI
    Primary source
    MGI:MGI:1289282
    See related
    Ensembl:ENSMUSG00000052253 AllianceGenome:MGI:1289282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZPR9; Znf622; D15Ertd806e; 1110033B05Rik
    Summary
    Predicted to enable preribosome binding activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of JNK cascade; and positive regulation of kinase activity. Predicted to be located in Golgi apparatus; cytosol; and nuclear lumen. Predicted to be part of preribosome, large subunit precursor. Is expressed in several structures, including central nervous system; early conceptus; and neural retina. Orthologous to human ZNF622 (zinc finger protein 622). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in colon adult (RPKM 15.0), ovary adult (RPKM 12.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp622 in Genome Data Viewer
    Location:
    15 B1; 15 9.71 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (25984452..25998568)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (25984366..25998482)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene reticulophagy regulator 1 Neighboring gene microRNA 7212 Neighboring gene STARR-positive B cell enhancer ABC_E7362 Neighboring gene predicted gene, 53887 Neighboring gene STARR-positive B cell enhancer mm9_chr15:25946080-25946381 Neighboring gene STARR-seq mESC enhancer starr_38204 Neighboring gene predicted gene, 41279 Neighboring gene predicted gene, 57625 Neighboring gene STARR-seq mESC enhancer starr_38206 Neighboring gene STARR-seq mESC enhancer starr_38207 Neighboring gene predicted gene, 52201

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    2. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables preribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables preribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic 60S subunit biogenesis factor ZNF622

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144523.3 → NP_653106.1  cytoplasmic 60S subunit biogenesis factor ZNF622

      Status: VALIDATED

      Source sequence(s)
      AC162303
      Consensus CDS
      CCDS27400.1
      UniProtKB/Swiss-Prot
      Q91VY9
      UniProtKB/TrEMBL
      Q3U343
      Related
      ENSMUSP00000059678.7, ENSMUST00000061875.8
      Conserved Domains (4) summary
      sd00020
      Location:6 → 28
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:70 → 93
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam12756
      Location:253 → 352
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
      cl00635
      Location:87 → 144
      Ntn_Asparaginase_2_like; L-Asparaginase type 2-like enzymes of the NTN-hydrolase superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      25984452..25998568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VY9.1 GenPept UniProtKB/Swiss-Prot:Q91VY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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