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    TAS2R41 taste 2 receptor member 41 [ Homo sapiens (human) ]

    Gene ID: 259287, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TAS2R41provided by HGNC
    Official Full Name
    taste 2 receptor member 41provided by HGNC
    Primary source
    HGNC:HGNC:18883
    See related
    Ensembl:ENSG00000221855 MIM:613965; AllianceGenome:HGNC:18883
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T2R41; T2R59
    Summary
    This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. Chloramphenicol is an agonist for the encoded protein. [provided by RefSeq, Jul 2017]
    Orthologs
    all
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    Genomic context

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    See TAS2R41 in Genome Data Viewer
    Location:
    7q35
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (143477873..143478796)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (144833246..144834169)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143174966..143175889)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene EPHA1 antisense RNA 1 Neighboring gene taste 2 receptor member 62 pseudogene Neighboring gene taste 2 receptor member 60 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:143169186-143170385 Neighboring gene Sharpr-MPRA regulatory region 6558 Neighboring gene uncharacterized LOC105375547 Neighboring gene olfactory receptor family 2 subfamily R member 1, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol. Thalmann S, et al. Biochem Biophys Res Commun, 2013 May 31. PMID 23632330
    2. Identification and characterization of human taste receptor genes belonging to the TAS2R family. Conte C, et al. Cytogenet Genome Res, 2002. PMID 12584440
    3. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Bufe B, et al. Nat Genet, 2002 Nov. PMID 12379855
    4. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. Go Y, et al. Genetics, 2005 May. PMID 15744053, Free PMC Article
    5. The molecular receptive ranges of human TAS2R bitter taste receptors. Meyerhof W, et al. Chem Senses, 2010 Feb. PMID 20022913

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119928, MGC119929

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables bitter taste receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in detection of chemical stimulus involved in sensory perception of bitter taste IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    taste receptor type 2 member 41
    Names
    taste receptor type 2 member 59
    taste receptor, type 2, member 41

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176883.2 → NP_795364.2  taste receptor type 2 member 41

      See identical proteins and their annotated locations for NP_795364.2

      Status: REVIEWED

      Source sequence(s)
      AY114093
      Consensus CDS
      CCDS43663.1
      UniProtKB/Swiss-Prot
      P59536, P59550, Q495I2, Q50KJ5, Q50KJ6, Q50KJ7, Q645W7
      Related
      ENSP00000386201.1, ENST00000408916.1
      Conserved Domains (1) summary
      cd15018
      Location:20 → 295
      7tm_TAS2R41-like; mammalian taste receptor 2, subtype 41, member of the seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      143477873..143478796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654714.1 Reference GRCh38.p14 PATCHES

      Range
      97237..98160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      144833246..144834169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59536.2 GenPept UniProtKB/Swiss-Prot:P59536

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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