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    TRMT11 tRNA methyltransferase 11 homolog [ Homo sapiens (human) ]

    Gene ID: 60487, updated on 21-Dec-2024

    Summary

    Official Symbol
    TRMT11provided by HGNC
    Official Full Name
    tRNA methyltransferase 11 homologprovided by HGNC
    Primary source
    HGNC:HGNC:21080
    See related
    Ensembl:ENSG00000066651 AllianceGenome:HGNC:21080
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRM11; MDS024; C6orf75; TRMT11-1
    Summary
    Predicted to enable methyltransferase activity. Predicted to be involved in methylation and tRNA processing. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in endometrium (RPKM 2.2), duodenum (RPKM 1.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRMT11 in Genome Data Viewer
    Location:
    6q22.32
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (125986540..126272343)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (127175155..127468301)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (126307686..126400874)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 7 Neighboring gene uncharacterized LOC124901397 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:126239365-126240564 Neighboring gene NCOA7-HINT3 intergenic CAGE-defined high expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25033 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:126306909-126307739 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:126307740-126308569 Neighboring gene RNA, 5S ribosomal pseudogene 216 Neighboring gene histidine triad nucleotide binding protein 3 Neighboring gene Sharpr-MPRA regulatory region 12057 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25035 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25036 Neighboring gene centromere protein W Neighboring gene microRNA 588

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (62 hits/1271 screens)

    EBI GWAS Catalog

    Description
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables methyltransferase activity  
    enables protein binding PubMed 
    enables tRNA (guanine(10)-N2)-methyltransferase activity  
    enables tRNA binding  
    Process Evidence Code Pubs
    involved_in methylation  
    involved_in tRNA processing  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    tRNA (guanine(10)-N(2))-methyltransferase homolog
    Names
    tRNA (guanine(10)-N2)-methyltransferase homolog
    tRNA guanosine-2'-O-methyltransferase TRM11 homolog
    NP_001026882.2
    NP_001337509.1
    NP_001337510.1
    NP_001337511.1
    NP_001337512.1
    NP_001337513.1
    NP_001337514.1
    NP_001337515.1
    NP_001337516.1
    NP_001337517.1
    NP_001337518.1
    NP_001337519.1
    NP_001337520.1
    NP_001337521.1
    NP_001337522.1
    NP_001337523.1
    NP_001337524.1
    NP_001337525.1
    NP_001337526.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031712.3 → NP_001026882.2  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform a

      See identical proteins and their annotated locations for NP_001026882.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AF532977, BC056878
      Consensus CDS
      CCDS35496.1
      UniProtKB/Swiss-Prot
      E1P570, Q5JY11, Q6PGQ5, Q7Z4G4, Q9HC13
      Related
      ENSP00000333934.5, ENST00000334379.11
      Conserved Domains (2) summary
      COG1041
      Location:9 → 416
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
      cl17173
      Location:190 → 321
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001350580.2 → NP_001337509.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform b

      Status: VALIDATED

      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:9 → 404
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    3. NM_001350581.2 → NP_001337510.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 4-6, encodes isoform c.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:7 → 353
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    4. NM_001350582.2 → NP_001337511.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 3, 5, and 6, encodes isoform c.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:7 → 353
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    5. NM_001350583.2 → NP_001337512.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 3, 4, and 6, encodes isoform c.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:7 → 353
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    6. NM_001350584.2 → NP_001337513.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 3-5, encodes isoform c.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:7 → 353
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    7. NM_001350585.2 → NP_001337514.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform d

      Status: VALIDATED

      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      COG1041
      Location:1 → 218
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    8. NM_001350586.2 → NP_001337515.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 9-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    9. NM_001350587.2 → NP_001337516.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 8 and 10-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    10. NM_001350588.2 → NP_001337517.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 8, 9, and 11-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    11. NM_001350589.2 → NP_001337518.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 8-10 and 12-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    12. NM_001350590.2 → NP_001337519.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 8-11 and 13-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    13. NM_001350591.2 → NP_001337520.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 8-12 and 14-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    14. NM_001350592.2 → NP_001337521.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 8-13 and 15-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    15. NM_001350593.2 → NP_001337522.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variants 8-14 and 16-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    16. NM_001350594.2 → NP_001337523.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variants 8-15 and 17-19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    17. NM_001350595.2 → NP_001337524.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17), as well as variants 8-16, 18, and 19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    18. NM_001350596.2 → NP_001337525.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variants 8-17 and 19, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    19. NM_001350597.2 → NP_001337526.1  tRNA (guanine(10)-N(2))-methyltransferase homolog isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19), as well as variants 8-18, encodes isoform e.
      Source sequence(s)
      AL035689
      Conserved Domains (1) summary
      cl28094
      Location:35 → 183
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    RNA

    1. NR_146795.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689
      Related
      ENST00000479748.5
    2. NR_146796.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689
    3. NR_146797.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689, AL391115
    4. NR_146798.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689
    5. NR_146799.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689, AL391115
    6. NR_146800.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689
    7. NR_146801.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689
    8. NR_146802.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689
    9. NR_146803.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689, AL391115
    10. NR_146804.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL035689, AL391115

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      125986540..126272343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007059327.1 RNA Sequence

    2. XR_007059304.1 RNA Sequence

    3. XR_007059310.1 RNA Sequence

    4. XR_007059309.1 RNA Sequence

    5. XR_007059298.1 RNA Sequence

    6. XR_007059293.1 RNA Sequence

    7. XR_007059296.1 RNA Sequence

    8. XR_007059311.1 RNA Sequence

    9. XR_007059324.1 RNA Sequence

    10. XR_007059325.1 RNA Sequence

    11. XR_007059326.1 RNA Sequence

    12. XR_007059301.1 RNA Sequence

    13. XR_007059299.1 RNA Sequence

    14. XR_007059297.1 RNA Sequence

    15. XR_007059290.1 RNA Sequence

    16. XR_007059302.1 RNA Sequence

    17. XR_007059314.1 RNA Sequence

    18. XR_007059289.1 RNA Sequence

    19. XR_007059303.1 RNA Sequence

    20. XR_007059307.1 RNA Sequence

    21. XR_007059312.1 RNA Sequence

    22. XR_007059291.1 RNA Sequence

    23. XR_007059306.1 RNA Sequence

    24. XR_007059295.1 RNA Sequence

    25. XR_007059313.1 RNA Sequence

    26. XR_007059322.1 RNA Sequence

    27. XR_007059323.1 RNA Sequence

    28. XR_007059316.1 RNA Sequence

    29. XR_007059317.1 RNA Sequence

    30. XR_007059320.1 RNA Sequence

    31. XR_007059305.1 RNA Sequence

    32. XR_007059321.1 RNA Sequence

    33. XR_007059300.1 RNA Sequence

    34. XR_007059294.1 RNA Sequence

    35. XR_007059315.1 RNA Sequence

    36. XR_007059292.1 RNA Sequence

    37. XR_007059318.1 RNA Sequence

    38. XR_007059319.1 RNA Sequence

    39. XR_007059308.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      127175155..127468301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008487421.1 RNA Sequence

    2. XR_008487389.1 RNA Sequence

    3. XR_008487395.1 RNA Sequence

    4. XR_008487394.1 RNA Sequence

    5. XR_008487383.1 RNA Sequence

    6. XR_008487379.1 RNA Sequence

    7. XR_008487382.1 RNA Sequence

    8. XR_008487396.1 RNA Sequence

    9. XR_008487419.1 RNA Sequence

    10. XR_008487420.1 RNA Sequence

    11. XR_008487386.1 RNA Sequence

    12. XR_008487384.1 RNA Sequence

    13. XR_008487376.1 RNA Sequence

    14. XR_008487387.1 RNA Sequence

    15. XR_008487375.1 RNA Sequence

    16. XR_008487388.1 RNA Sequence

    17. XR_008487392.1 RNA Sequence

    18. XR_008487397.1 RNA Sequence

    19. XR_008487377.1 RNA Sequence

    20. XR_008487391.1 RNA Sequence

    21. XR_008487381.1 RNA Sequence

    22. XR_008487398.1 RNA Sequence

    23. XR_008487417.1 RNA Sequence

    24. XR_008487400.1 RNA Sequence

    25. XR_008487401.1 RNA Sequence

    26. XR_008487399.1 RNA Sequence

    27. XR_008487403.1 RNA Sequence

    28. XR_008487405.1 RNA Sequence

    29. XR_008487402.1 RNA Sequence

    30. XR_008487404.1 RNA Sequence

    31. XR_008487406.1 RNA Sequence

    32. XR_008487407.1 RNA Sequence

    33. XR_008487413.1 RNA Sequence

    34. XR_008487416.1 RNA Sequence

    35. XR_008487418.1 RNA Sequence

    36. XR_008487410.1 RNA Sequence

    37. XR_008487414.1 RNA Sequence

    38. XR_008487390.1 RNA Sequence

    39. XR_008487415.1 RNA Sequence

    40. XR_008487385.1 RNA Sequence

    41. XR_008487380.1 RNA Sequence

    42. XR_008487409.1 RNA Sequence

    43. XR_008487378.1 RNA Sequence

    44. XR_008487411.1 RNA Sequence

    45. XR_008487412.1 RNA Sequence

    46. XR_008487393.1 RNA Sequence

    47. XR_008487408.1 RNA Sequence

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