BRSK2 BR serine/threonine kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: BRSK2provided by HGNC
Official Full Name: BR serine/threonine kinase 2provided by HGNC
Primary source: HGNC:HGNC:11405
See related: Ensembl:ENSG00000174672 MIM:609236; AllianceGenome:HGNC:11405
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SAD1; SADA; SAD-A; STK29; PEN11B; C11orf7
Summary: Enables several functions, including ATP binding activity; ATPase binding activity; and protein kinase activity. Involved in several processes, including G2/M transition of mitotic cell cycle; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of insulin secretion involved in cellular response to glucose stimulus. Located in centrosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in brain (RPKM 8.8), pancreas (RPKM 3.6) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.5

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (1389934..1462689)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (1461201..1537121)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (1411164..1483919)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BRSK2 in pancreatic beta cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes.
Title: BRSK2 in pancreatic β cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes.
STK39 is a novel kinase contributing to the progression of hepatocellular carcinoma by the PLK1/ERK signaling pathway.
Title: STK39 is a novel kinase contributing to the progression of hepatocellular carcinoma by the PLK1/ERK signaling pathway.
damaging variation in BRSK2 is a source of neurodevelopmental disease
Title: Deleterious Variation in BRSK2 Associates with a Neurodevelopmental Disorder.
the intrinsic molecular merit that BRSK2 provides is a survival advantage to PDAC cells and strengthens the invasiveness of these neoplastic cells in energy-deprived environments.
Title: BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity.
SAD-A and AMPK kinases are regulators of mTORC1 signaling in the pancreatic beta-cells.
Title: SAD-A and AMPK kinases: the "yin and yang" regulators of mTORC1 signaling in pancreatic β cells.
BRSK2 interacted with VCP/p97 via three of the four functional domains of VCP/p97. Immunofluorescence demonstrated that BRSK2 and VCP/p97 were co-localized and also that knockdown of endogenous BRSK2 induced increased levels of CD3delta.
Title: BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation.
Anaphase-promoting complex/cyclosome-Cdh1, rather than Cdc20, promotes the degradation of BRSK2 in vivo.
Title: APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway.
a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs.
Title: Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells.
these findings demonstrate ER stress may reduce BRSK2 protein and change BRSK2 subcellular localization, which in turn alleviate ER stress-induced apoptosis.
Title: BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis.
these findings provide a novel regulatory mechanism of BRSK2 through direct interaction with Jab1.
Title: Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH91860 (e-PCR)
- UniSTS:90637

SHGC-146355 (e-PCR)
- UniSTS:172591

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATPase binding	IDA Inferred from Direct Assay more info	PubMed
enables ATPase regulator activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables tau protein binding	NAS Non-traceable Author Statement more info	PubMed
enables tau-protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tau-protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables tau-protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tau-protein kinase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization involved in establishment of planar polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cell cycle checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of ATP-dependent activity	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of retrograde protein transport, ER to cytosol	IC Inferred by Curator more info	PubMed
involved_in regulation of retrograde protein transport, ER to cytosol	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of synaptic vesicle clustering	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in distal axon	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase BRSK2

Names: BR serine/threonine-protein kinase 2; brain-selective kinase 2; brain-specific serine/threonine-protein kinase 2; protein kinase SAD1B; serine/threonine-protein kinase 29; serine/threonine-protein kinase SAD-A; testicular tissue protein Li 30

NP_001243556.1

EC 2.7.11.1

EC 2.7.11.26

NP_001243558.1

EC 2.7.11.1

EC 2.7.11.26

NP_001243559.1

EC 2.7.11.1

EC 2.7.11.26

NP_001269147.1

EC 2.7.11.1

EC 2.7.11.26

NP_003948.2

EC 2.7.11.1

EC 2.7.11.26

XP_005253275.1

EC 2.7.11.1

EC 2.7.11.26

XP_006718437.1

EC 2.7.11.1

EC 2.7.11.26

XP_006718439.1

EC 2.7.11.1

EC 2.7.11.26

XP_011518763.1

EC 2.7.11.1

EC 2.7.11.26

XP_011518764.1

EC 2.7.11.1

EC 2.7.11.26

XP_016874021.1

EC 2.7.11.1

EC 2.7.11.26

XP_016874022.1

EC 2.7.11.1

EC 2.7.11.26

XP_016874023.1

EC 2.7.11.1

EC 2.7.11.26

XP_016874024.1

EC 2.7.11.1

EC 2.7.11.26

XP_016874025.1

EC 2.7.11.1

EC 2.7.11.26

XP_016874026.1

EC 2.7.11.1

EC 2.7.11.26

XP_047283806.1

EC 2.7.11.1

EC 2.7.11.26

XP_047283807.1

EC 2.7.11.1

EC 2.7.11.26

XP_047283808.1

EC 2.7.11.1

EC 2.7.11.26

XP_047283809.1

EC 2.7.11.1

EC 2.7.11.26

XP_047283810.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189097.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189098.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189099.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189100.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189101.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189102.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189103.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189104.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189105.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189106.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189107.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189108.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189109.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189110.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189111.1

EC 2.7.11.1

EC 2.7.11.26

XP_054189112.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226408.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226409.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226410.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226411.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226412.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226413.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226414.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226415.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226416.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226417.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226418.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226419.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226420.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226421.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226422.1

EC 2.7.11.1

EC 2.7.11.26

XP_054226423.1

EC 2.7.11.1

EC 2.7.11.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256627.2 → NP_001243556.1 serine/threonine-protein kinase BRSK2 isoform 1

See identical proteins and their annotated locations for NP_001243556.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.

Source sequence(s)

AC091196, AC136297, AF533879, AK131534

Consensus CDS

CCDS58107.1

UniProtKB/Swiss-Prot

B3KVE9, E9PLM7, O60843, O95099, Q5J5B4, Q6ZMQ4, Q8IWQ3, Q8TB60

Related

ENSP00000432000.1, ENST00000528841.6

Conserved Domains (3) summary

smart00220
Location:19 → 269

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14340
Location:297 → 350

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:17 → 270

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
NM_001256629.2 → NP_001243558.1 serine/threonine-protein kinase BRSK2 isoform 3

See identical proteins and their annotated locations for NP_001243558.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC091196, AC136297, AF533877, AK131534

Consensus CDS

CCDS58106.1

Related

ENSP00000431152.1, ENST00000531197.5

Conserved Domains (2) summary

cd14340
Location:297 → 350

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:17 → 270

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
NM_001256630.1 → NP_001243559.1 serine/threonine-protein kinase BRSK2 isoform 4

See identical proteins and their annotated locations for NP_001243559.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, initiates translation at an alternate start codon and uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is longer and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC091196, AK131534

Consensus CDS

CCDS58108.1

UniProtKB/Swiss-Prot

Q8IWQ3

Related

ENSP00000371614.1, ENST00000382179.5

Conserved Domains (3) summary

smart00220
Location:77 → 315

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14340
Location:343 → 396

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:62 → 316

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
NM_001282218.2 → NP_001269147.1 serine/threonine-protein kinase BRSK2 isoform 5

See identical proteins and their annotated locations for NP_001269147.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in both UTRs and has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The resulting protein (isoform 5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC091196, AK122851, AK297211

Consensus CDS

CCDS60696.1

UniProtKB/Swiss-Prot

Q8IWQ3

UniProtKB/TrEMBL

B4DLY3

Related

ENSP00000433235.1, ENST00000528710.5

Conserved Domains (2) summary

cd14340
Location:237 → 290

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:1 → 210

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
NM_003957.4 → NP_003948.2 serine/threonine-protein kinase BRSK2 isoform 2

See identical proteins and their annotated locations for NP_003948.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC091196, AC136297, AY166857, DA059153

Consensus CDS

CCDS41590.1

UniProtKB/TrEMBL

A0A140VJF6

Related

ENSP00000310697.9, ENST00000308219.13

Conserved Domains (2) summary

cd14340
Location:297 → 350

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:17 → 270

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2

RNA

NR_046331.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) contains two alternate exons in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC091196, AC136297, AF533880, AK131534

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

1389934..1462689

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017018533.2 → XP_016874022.1 serine/threonine-protein kinase BRSK2 isoform X1
XM_047427850.1 → XP_047283806.1 serine/threonine-protein kinase BRSK2 isoform X3
XM_006718374.3 → XP_006718437.1 serine/threonine-protein kinase BRSK2 isoform X5

Conserved Domains (3) summary

smart00220
Location:19 → 269

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14340
Location:297 → 350

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:17 → 270

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_017018536.2 → XP_016874025.1 serine/threonine-protein kinase BRSK2 isoform X2
XM_047427851.1 → XP_047283807.1 serine/threonine-protein kinase BRSK2 isoform X4
XM_005253218.4 → XP_005253275.1 serine/threonine-protein kinase BRSK2 isoform X6

Conserved Domains (3) summary

smart00220
Location:19 → 269

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14340
Location:297 → 350

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:17 → 270

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_017018532.2 → XP_016874021.1 serine/threonine-protein kinase BRSK2 isoform X7
XM_017018534.2 → XP_016874023.1 serine/threonine-protein kinase BRSK2 isoform X8
XM_017018537.2 → XP_016874026.1 serine/threonine-protein kinase BRSK2 isoform X10
XM_006718376.3 → XP_006718439.1 serine/threonine-protein kinase BRSK2 isoform X11

See identical proteins and their annotated locations for XP_006718439.1

Conserved Domains (3) summary

smart00220
Location:2 → 209

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14340
Location:237 → 290

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:1 → 210

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_047427852.1 → XP_047283808.1 serine/threonine-protein kinase BRSK2 isoform X12
XM_047427853.1 → XP_047283809.1 serine/threonine-protein kinase BRSK2 isoform X15
XM_017018535.2 → XP_016874024.1 serine/threonine-protein kinase BRSK2 isoform X9
XM_011520461.3 → XP_011518763.1 serine/threonine-protein kinase BRSK2 isoform X13

Conserved Domains (3) summary

smart00220
Location:2 → 209

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14340
Location:237 → 290

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:1 → 210

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_011520462.3 → XP_011518764.1 serine/threonine-protein kinase BRSK2 isoform X14

Conserved Domains (3) summary

smart00220
Location:2 → 209

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14340
Location:237 → 290

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:1 → 210

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_047427854.1 → XP_047283810.1 serine/threonine-protein kinase BRSK2 isoform X16

Reference GRCh38.p14 PATCHES

Genomic

NW_025791792.1 Reference GRCh38.p14 PATCHES

Range

124200..196955

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054333123.1 → XP_054189098.1 serine/threonine-protein kinase BRSK2 isoform X1
XM_054333128.1 → XP_054189103.1 serine/threonine-protein kinase BRSK2 isoform X3
XM_054333131.1 → XP_054189106.1 serine/threonine-protein kinase BRSK2 isoform X5
XM_054333126.1 → XP_054189101.1 serine/threonine-protein kinase BRSK2 isoform X2
XM_054333129.1 → XP_054189104.1 serine/threonine-protein kinase BRSK2 isoform X4
XM_054333135.1 → XP_054189110.1 serine/threonine-protein kinase BRSK2 isoform X6
XM_054333122.1 → XP_054189097.1 serine/threonine-protein kinase BRSK2 isoform X17
XM_054333124.1 → XP_054189099.1 serine/threonine-protein kinase BRSK2 isoform X18
XM_054333125.1 → XP_054189100.1 serine/threonine-protein kinase BRSK2 isoform X19
XM_054333127.1 → XP_054189102.1 serine/threonine-protein kinase BRSK2 isoform X20
XM_054333130.1 → XP_054189105.1 serine/threonine-protein kinase BRSK2 isoform X21
XM_054333132.1 → XP_054189107.1 serine/threonine-protein kinase BRSK2 isoform X22
XM_054333133.1 → XP_054189108.1 serine/threonine-protein kinase BRSK2 isoform X23
XM_054333134.1 → XP_054189109.1 serine/threonine-protein kinase BRSK2 isoform X24
XM_054333136.1 → XP_054189111.1 serine/threonine-protein kinase BRSK2 isoform X25
XM_054333137.1 → XP_054189112.1 serine/threonine-protein kinase BRSK2 isoform X26

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

1461201..1537121

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054370434.1 → XP_054226409.1 serine/threonine-protein kinase BRSK2 isoform X1
XM_054370439.1 → XP_054226414.1 serine/threonine-protein kinase BRSK2 isoform X3
XM_054370442.1 → XP_054226417.1 serine/threonine-protein kinase BRSK2 isoform X5
XM_054370437.1 → XP_054226412.1 serine/threonine-protein kinase BRSK2 isoform X2
XM_054370440.1 → XP_054226415.1 serine/threonine-protein kinase BRSK2 isoform X4
XM_054370446.1 → XP_054226421.1 serine/threonine-protein kinase BRSK2 isoform X6
XM_054370433.1 → XP_054226408.1 serine/threonine-protein kinase BRSK2 isoform X27
XM_054370435.1 → XP_054226410.1 serine/threonine-protein kinase BRSK2 isoform X28
XM_054370436.1 → XP_054226411.1 serine/threonine-protein kinase BRSK2 isoform X29
XM_054370438.1 → XP_054226413.1 serine/threonine-protein kinase BRSK2 isoform X30
XM_054370441.1 → XP_054226416.1 serine/threonine-protein kinase BRSK2 isoform X31
XM_054370443.1 → XP_054226418.1 serine/threonine-protein kinase BRSK2 isoform X32
XM_054370444.1 → XP_054226419.1 serine/threonine-protein kinase BRSK2 isoform X33
XM_054370445.1 → XP_054226420.1 serine/threonine-protein kinase BRSK2 isoform X34
XM_054370447.1 → XP_054226422.1 serine/threonine-protein kinase BRSK2 isoform X35
XM_054370448.1 → XP_054226423.1 serine/threonine-protein kinase BRSK2 isoform X36