U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FOXB1 forkhead box B1 [ Homo sapiens (human) ]

    Gene ID: 27023, updated on 10-Dec-2024

    Summary

    Official Symbol
    FOXB1provided by HGNC
    Official Full Name
    forkhead box B1provided by HGNC
    Primary source
    HGNC:HGNC:3799
    See related
    Ensembl:ENSG00000171956 MIM:619961; AllianceGenome:HGNC:3799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FKH5; HFKH-5
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including mammary gland development; nervous system development; and visual learning. Predicted to be located in chromatin and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FOXB1 in Genome Data Viewer
    Location:
    15q22.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (60004311..60007444)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (57805997..57809133)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (60296510..60299643)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 18 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9501 Neighboring gene NMNAT1 pseudogene 5 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:60287460-60288247 Neighboring gene NANOG hESC enhancer GRCh37_chr15:60296191-60296706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9503 Neighboring gene Sharpr-MPRA regulatory region 13950 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:60301179-60301777 Neighboring gene uncharacterized LOC105370838 Neighboring gene mesoderm specific transcript pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axon target recognition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration in diencephalon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epithelial cell differentiation involved in mammary gland alveolus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in floor plate development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hypothalamus cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inferior colliculus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lactation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mammary gland lobule development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mammillary body development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mammillothalamic axonal tract development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in midbrain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in somitogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spinal cord development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in telencephalon cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in thalamus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in urogenital system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in visual learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    forkhead box protein B1
    Names
    transcription factor FKH-5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012182.3NP_036314.2  forkhead box protein B1

      See identical proteins and their annotated locations for NP_036314.2

      Status: VALIDATED

      Source sequence(s)
      AC009654, AF071554, DA685771
      Consensus CDS
      CCDS32255.1
      UniProtKB/Swiss-Prot
      O60652, O75917, Q14CL2, Q99853
      Related
      ENSP00000379369.4, ENST00000396057.6
      Conserved Domains (1) summary
      cd20043
      Location:1110
      FH_FOXB2; Forkhead (FH) domain found in Forkhead box protein B2 (FOXB2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      60004311..60007444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      57805997..57809133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)