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    Pde4dip phosphodiesterase 4D interacting protein (myomegalin) [ Mus musculus (house mouse) ]

    Gene ID: 83679, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pde4dipprovided by MGI
    Official Full Name
    phosphodiesterase 4D interacting protein (myomegalin)provided by MGI
    Primary source
    MGI:MGI:1891434
    See related
    Ensembl:ENSMUSG00000038170 AllianceGenome:MGI:1891434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Usmg4; mKIAA0454; D3Bwg1078e; 4732458A06Rik; 9430063L05Rik; D130016K21Rik
    Summary
    Predicted to enable enzyme binding activity and molecular adaptor activity. Predicted to be involved in microtubule cytoskeleton organization; protein-containing complex assembly; and regulation of organelle organization. Predicted to be located in myofibril and nucleus. Predicted to be active in Golgi apparatus and centrosome. Predicted to colocalize with cortical microtubule plus-end. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human PDE4DIP (phosphodiesterase 4D interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 75.3), mammary gland adult (RPKM 16.2) and 13 other tissues See more
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    Genomic context

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    See Pde4dip in Genome Data Viewer
    Location:
    3 F2.2; 3 42.28 cM
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (97597144..97796023, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (97689828..97888707, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9010 Neighboring gene STARR-positive B cell enhancer ABC_E6086 Neighboring gene protein kinase, AMP-activated, beta 2 non-catalytic subunit Neighboring gene nuclear encoded tRNA glutamine 2 (anticodon CTG) Neighboring gene predicted gene, 31242 Neighboring gene microRNA 7225 Neighboring gene predicted gene, 31305 Neighboring gene STARR-positive B cell enhancer ABC_E7930 Neighboring gene predicted gene, 46816 Neighboring gene transformer 2 alpha homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_08475 Neighboring gene STARR-positive B cell enhancer ABC_E4564 Neighboring gene SEC22 homolog B, vesicle trafficking protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:97732943-97733126 Neighboring gene STARR-positive B cell enhancer ABC_E3452 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:97737302-97737411 Neighboring gene VISTA enhancer mm576 Neighboring gene predicted gene 5544

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hemodynamic stress-induced cardiac remodelling is not modulated by ablation of phosphodiesterase 4D interacting protein. Mohamed BA, et al. J Cell Mol Med, 2022 Aug. PMID 35860864, Free PMC Article
    2. Generation of mice lacking DUF1220 protein domains: effects on fecundity and hyperactivity. Keeney JG, et al. Mamm Genome, 2015 Feb. PMID 25308000, Free PMC Article
    3. Direct interaction of the Usher syndrome 1G protein SANS and myomegalin in the retina. Overlack N, et al. Biochim Biophys Acta, 2011 Oct. PMID 21767579
    4. Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. Verde I, et al. J Biol Chem, 2001 Apr 6. PMID 11134006
    5. Global/temporal gene expression in diaphragm and hindlimb muscles of dystrophin-deficient (mdx) mice. Rouger K, et al. Am J Physiol Cell Physiol, 2002 Sep. PMID 12176734

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0477, MGC176146

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in astral microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    colocalizes_with cortical microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myofibril ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    myomegalin
    Names
    phosphodiesterase 4D-interacting protein
    upregulated during skeletal muscle growth 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039376.2 → NP_001034465.2  myomegalin isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 5. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 5.
      Source sequence(s)
      AA727946, AC130541, AK122286, BB636676, BC028274, BC046620, BM950385, BQ042855, BQ554472, BU613416, BX517394, CB523595, CF532518, CO428791, CO432192, CR757260
      UniProtKB/TrEMBL
      B2RUJ9
      Conserved Domains (4) summary
      TIGR02168
      Location:123 → 770
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06758
      Location:1684 → 1745
      DUF1220; Repeat of unknown function (DUF1220)
      pfam07851
      Location:362 → 457
      TMPIT; TMPIT-like protein
      pfam07989
      Location:126 → 193
      Cnn_1N; Centrosomin N-terminal motif 1

    2. NM_001289701.1 → NP_001276630.1  myomegalin isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
      Source sequence(s)
      AC130541, AC131746, AC153661
      Consensus CDS
      CCDS79985.1
      UniProtKB/TrEMBL
      B2RUJ9, G3X9L9
      Related
      ENSMUSP00000088254.6, ENSMUST00000090750.12
      Conserved Domains (4) summary
      TIGR02168
      Location:123 → 770
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06758
      Location:1684 → 1745
      DUF1220; Repeat of unknown function (DUF1220)
      pfam07851
      Location:362 → 457
      TMPIT; TMPIT-like protein
      pfam07989
      Location:126 → 193
      Cnn_1N; Centrosomin N-terminal motif 1

    3. NM_001289702.1 → NP_001276631.1  myomegalin isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 5. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 5.
      Source sequence(s)
      AC130541, AC131746, AC153661
      Consensus CDS
      CCDS79984.1
      UniProtKB/TrEMBL
      B7ZNY0, E9Q1A0
      Related
      ENSMUSP00000131170.3, ENSMUST00000168438.9
      Conserved Domains (4) summary
      TIGR02168
      Location:123 → 770
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06758
      Location:1684 → 1745
      DUF1220; Repeat of unknown function (DUF1220)
      pfam07851
      Location:362 → 457
      TMPIT; TMPIT-like protein
      pfam07989
      Location:126 → 193
      Cnn_1N; Centrosomin N-terminal motif 1

    4. NM_178080.4 → NP_835181.2  myomegalin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the UTRs and coding region compared to variant 5. The resulting isoform (2) has much shorter and distinct N- and C-termini compared to isoform 5.
      Source sequence(s)
      BC050783, BU506330, CJ127389
      Consensus CDS
      CCDS38562.1
      UniProtKB/Swiss-Prot
      Q80YT7
      Related
      ENSMUSP00000040905.9, ENSMUST00000045243.15
      Conserved Domains (3) summary
      PRK02224
      Location:637 → 1116
      PRK02224; chromosome segregation protein; Provisional
      pfam07776
      Location:4 → 78
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam07851
      Location:405 → 500
      TMPIT; TMPIT-like protein

    RNA

    1. NR_110360.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC153661, AK122286, BC057350, BP760882

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      97597144..97796023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001110163.1: Suppressed sequence

      Description
      NM_001110163.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_031401.2: Suppressed sequence

      Description
      NM_031401.2: This RefSeq was permanently suppressed because it comprises 3' UTR sequence and does not encode any part of the Pde4dip protein.

    3. NM_177145.3: Suppressed sequence

      Description
      NM_177145.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YT7.2 GenPept UniProtKB/Swiss-Prot:Q80YT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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