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    TMEM81 transmembrane protein 81 [ Homo sapiens (human) ]

    Gene ID: 388730, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TMEM81provided by HGNC
    Official Full Name
    transmembrane protein 81provided by HGNC
    Primary source
    HGNC:HGNC:32349
    See related
    Ensembl:ENSG00000174529 AllianceGenome:HGNC:32349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HC3107; UNQ2788; KVLA2788
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    mouse all
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    Genomic context

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    See TMEM81 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (205083129..205084460, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (204347508..204348839, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205052257..205053588, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene neurofascin Neighboring gene ribosomal protein L13a pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2373 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:204981530-204982083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:204983191-204983742 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:204987113-204987910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:204987911-204988706 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:204994888-204995728 Neighboring gene melanoma risk locus-associated MPRA allelic enhancers 1:205012106 and 1:205012198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205016337-205016841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205023369-205024096 Neighboring gene contactin 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:205041546-205042745 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:205044866 Neighboring gene melanoma risk locus-associated MPRA allelic enhancers 1:205044354 and 1:205044416 Neighboring gene Sharpr-MPRA regulatory region 1805 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:205074018 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:205075359 Neighboring gene RB binding protein 5, histone lysine methyltransferase complex subunit Neighboring gene glycogenin 2 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205089166-205089724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2374 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2375 Neighboring gene Sharpr-MPRA regulatory region 3970 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205101461-205101961 Neighboring gene signal peptidase complex subunit 1-like Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:205104550 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:205106956-205107504

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved fertilization complex bridges sperm and egg in vertebrates. Deneke VE, et al. Cell, 2024 Dec 12. PMID 39423812
    2. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC75217

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 81

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203376.2 → NP_976310.1  transmembrane protein 81 precursor

      See identical proteins and their annotated locations for NP_976310.1

      Status: VALIDATED

      Source sequence(s)
      AY359081, BC061592
      Consensus CDS
      CCDS1450.1
      UniProtKB/Swiss-Prot
      Q6P7N7, Q6UVZ4
      UniProtKB/TrEMBL
      B4E0M0
      Related
      ENSP00000356135.3, ENST00000367167.4
      Conserved Domains (1) summary
      cl11960
      Location:93 → 163
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      205083129..205084460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      204347508..204348839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P7N7.1 GenPept UniProtKB/Swiss-Prot:Q6P7N7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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