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    TMEM179B transmembrane protein 179B [ Homo sapiens (human) ]

    Gene ID: 374395, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TMEM179Bprovided by HGNC
    Official Full Name
    transmembrane protein 179Bprovided by HGNC
    Primary source
    HGNC:HGNC:33744
    See related
    Ensembl:ENSG00000185475 AllianceGenome:HGNC:33744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Located in nuclear speck and nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 21.9), thyroid (RPKM 20.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM179B in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62787402..62790400)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62776793..62779792)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62554874..62557872)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4844 Neighboring gene RNA polymerase II subunit G Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4845 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4846 Neighboring gene transmembrane protein 223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4847 Neighboring gene TATA-box binding protein associated factor 6 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4848 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3431 Neighboring gene microRNA 6748 Neighboring gene microRNA 6514 Neighboring gene nuclear RNA export factor 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62572705-62573204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4851 Neighboring gene syntaxin 5 Neighboring gene RNA, U6 small nuclear 118, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of gene expression in human trabecular meshwork using single-pass sequencing of 1060 clones. Gonzalez P, et al. Invest Ophthalmol Vis Sci, 2000 Nov. PMID 11053263
    2. Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2. Snieder B, et al. SLAS Discov, 2019 Oct. PMID 31318583
    3. Assessment of community efforts to advance network-based prediction of protein-protein interactions. Wang XW, et al. Nat Commun, 2023 Mar 22. PMID 36949045, Free PMC Article
    4. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
    5. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in azurophil granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 179B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363599.1 → NP_001350528.1  transmembrane protein 179B isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AP001160
      Consensus CDS
      CCDS91494.1
      UniProtKB/TrEMBL
      G3V185
      Related
      ENSP00000433055.1, ENST00000533861.5

    2. NM_001363600.1 → NP_001350529.1  transmembrane protein 179B isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AP001160

    3. NM_001363601.1 → NP_001350530.1  transmembrane protein 179B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AP001160

    4. NM_199337.3 → NP_955369.1  transmembrane protein 179B isoform 1 precursor

      See identical proteins and their annotated locations for NP_955369.1

      Status: VALIDATED

      Source sequence(s)
      BC051355, BE439533, BM684628
      Consensus CDS
      CCDS8036.1
      UniProtKB/Swiss-Prot
      Q7Z7N9
      Related
      ENSP00000333697.3, ENST00000333449.9

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      62787402..62790400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      62776793..62779792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z7N9.1 GenPept UniProtKB/Swiss-Prot:Q7Z7N9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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