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    DDIAS DNA damage induced apoptosis suppressor [ Homo sapiens (human) ]

    Gene ID: 220042, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DDIASprovided by HGNC
    Official Full Name
    DNA damage induced apoptosis suppressorprovided by HGNC
    Primary source
    HGNC:HGNC:26351
    See related
    Ensembl:ENSG00000165490 MIM:618045; AllianceGenome:HGNC:26351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    noxin; C11orf82
    Summary
    Involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage and regulation of DNA stability. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 5.9), lymph node (RPKM 1.9) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DDIAS in Genome Data Viewer
    Location:
    11q14.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (82901736..82934659)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (82825989..82871120)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (82612778..82645701)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 6 Neighboring gene prolylcarboxypeptidase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:82569102-82570301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5335 Neighboring gene MIR3 retrotransposon enhancer-blocking element Neighboring gene uncharacterized LOC124902602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5337 Neighboring gene ribosomal protein L7a pseudogene 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5340 Neighboring gene RAB30, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5341 Neighboring gene small nucleolar RNA, H/ACA box 70E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells. Im JY, et al. Oncogene, 2018 Mar. PMID 29242605
    2. DNA damage induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes β-catenin-mediated invasion. Im JY, et al. Biochim Biophys Acta, 2016 Nov. PMID 27412911
    3. NOXIN as a cofactor of DNA polymerase-primase complex could promote hepatocellular carcinoma. Zhang ZZ, et al. Int J Cancer, 2015 Aug 15. PMID 25612832
    4. DNA damage-induced apoptosis suppressor (DDIAS), a novel target of NFATc1, is associated with cisplatin resistance in lung cancer. Im JY, et al. Biochim Biophys Acta, 2016 Jan. PMID 26493727
    5. Human Noxin is an anti-apoptotic protein in response to DNA damage of A549 non-small cell lung carcinoma. Won KJ, et al. Int J Cancer, 2014 Jun 1. PMID 24214091

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High DDIAS expression suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in lung and liver cancer.
      Title: DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells.
    2. these findings indicate that the stability of the DDIAS protein is regulated by CHIP/HSP70-mediated proteasomal degradation and that CHIP overexpression stimulates the apoptosis of lung cancer cells in response to DNA-damaging agents
      Title: Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells.
    3. Noxin facilitated the expression of Cyclin D1 and Cyclin E1 through activating P38-activating transcription factor 2 signaling pathway, thus enhanced cell growth of breast cancer
      Title: Noxin promotes proliferation of breast cancer cells via P38-ATF2 signaling pathway.
    4. EGF activates the ERK5/MEF2 pathway, which in turn induces DDIAS expression to promote cancer cell invasion by activating beta-catenin target genes
      Title: DNA damage induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes β-catenin-mediated invasion.
    5. DDIAS is a target of NFATc1 and is associated with cisplatin resistance in lung cancer cells.
      Title: DNA damage-induced apoptosis suppressor (DDIAS), a novel target of NFATc1, is associated with cisplatin resistance in lung cancer.
    6. NOXIN overexpression, as a result of genomic DNA gain or amplification, promotes HCC tumorigenesis by accelerating DNA synthesis and cell cycle progression, where NOXIN functions as a cofactor of DNA polymerase-primase complex
      Title: NOXIN as a cofactor of DNA polymerase-primase complex could promote hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13936, FLJ25416, FLJ38838

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA damage-induced apoptosis suppressor protein
    Names
    nitric oxide-inducible gene protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363481.2 → NP_001350410.1  DNA damage-induced apoptosis suppressor protein

      Status: VALIDATED

      Source sequence(s)
      AP001646
      Consensus CDS
      CCDS8263.1
      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
      UniProtKB/TrEMBL
      A8K8N4
      Related
      ENSP00000329930.4, ENST00000329143.4
      Conserved Domains (1) summary
      cl09930
      Location:8 → 130
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

    2. NM_145018.4 → NP_659455.3  DNA damage-induced apoptosis suppressor protein

      See identical proteins and their annotated locations for NP_659455.3

      Status: VALIDATED

      Source sequence(s)
      AA477171, AK096157, BC039268, DB023053, DB454086
      Consensus CDS
      CCDS8263.1
      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
      UniProtKB/TrEMBL
      A8K8N4
      Related
      ENSP00000435421.1, ENST00000533655.6
      Conserved Domains (1) summary
      cl09930
      Location:8 → 130
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      82901736..82934659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448400.2 → XP_024304168.1  DNA damage-induced apoptosis suppressor protein isoform X1

      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
      UniProtKB/TrEMBL
      A8K8N4
      Conserved Domains (1) summary
      cl09930
      Location:8 → 130
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

    2. XM_011544836.3 → XP_011543138.1  DNA damage-induced apoptosis suppressor protein isoform X1

      See identical proteins and their annotated locations for XP_011543138.1

      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
      UniProtKB/TrEMBL
      A8K8N4
      Conserved Domains (1) summary
      cl09930
      Location:8 → 130
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

    3. XM_011544837.2 → XP_011543139.1  DNA damage-induced apoptosis suppressor protein isoform X2

      See identical proteins and their annotated locations for XP_011543139.1

      UniProtKB/TrEMBL
      B4DMA1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      82825989..82871120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368021.1 → XP_054223996.1  DNA damage-induced apoptosis suppressor protein isoform X1

      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
      UniProtKB/TrEMBL
      A8K8N4

    2. XM_054368019.1 → XP_054223994.1  DNA damage-induced apoptosis suppressor protein isoform X1

      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
      UniProtKB/TrEMBL
      A8K8N4

    3. XM_054368022.1 → XP_054223997.1  DNA damage-induced apoptosis suppressor protein isoform X1

      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
      UniProtKB/TrEMBL
      A8K8N4

    4. XM_054368020.1 → XP_054223995.1  DNA damage-induced apoptosis suppressor protein isoform X1

      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
      UniProtKB/TrEMBL
      A8K8N4

    5. XM_054368023.1 → XP_054223998.1  DNA damage-induced apoptosis suppressor protein isoform X1

      UniProtKB/Swiss-Prot
      Q8IXT1, Q96LK6, Q9H856
      UniProtKB/TrEMBL
      A8K8N4

    6. XM_054368024.1 → XP_054223999.1  DNA damage-induced apoptosis suppressor protein isoform X2

      UniProtKB/TrEMBL
      B4DMA1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IXT1.2 GenPept UniProtKB/Swiss-Prot:Q8IXT1

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