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    PINLYP phospholipase A2 inhibitor and LY6/PLAUR domain containing [ Homo sapiens (human) ]

    Gene ID: 390940, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PINLYPprovided by HGNC
    Official Full Name
    phospholipase A2 inhibitor and LY6/PLAUR domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:44206
    See related
    Ensembl:ENSG00000234465 AllianceGenome:HGNC:44206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable phospholipase inhibitor activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 1.9), endometrium (RPKM 1.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PINLYP in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43575509..43582098)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46397139..46403730)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44079953..44086250)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44017305-44017805 Neighboring gene ETHE1 persulfide dioxygenase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44029999-44030504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44030505-44031009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10721 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:44035307-44035478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10722 Neighboring gene zinc finger protein 575 Neighboring gene X-ray repair cross complementing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44067237-44067737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:44080053-44080579 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:44080580-44081105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14728 Neighboring gene immunity related GTPase Q Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:44098910-44099706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14730 Neighboring gene zinc finger protein 576

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article
    2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phospholipase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193621.3 → NP_001180550.2  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
      Source sequence(s)
      AC006276, L34079
      Consensus CDS
      CCDS74385.2
      UniProtKB/Swiss-Prot
      A6NC86, B7Z457, O95053
      Related
      ENSP00000469886.1, ENST00000599207.6
      Conserved Domains (1) summary
      cl10471
      Location:27 → 107
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    2. NM_001193622.2 → NP_001180551.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_001180551.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same protein.
      Source sequence(s)
      AI298189, BC071811
      Consensus CDS
      CCDS58667.1
      UniProtKB/Swiss-Prot
      A6NC86
      Related
      ENSP00000457623.1, ENST00000562255.5
      Conserved Domains (1) summary
      cl10471
      Location:38 → 88
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    3. NM_001321124.2 → NP_001308053.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same protein.
      Source sequence(s)
      CN355575, HY005068
      Consensus CDS
      CCDS58667.1
      UniProtKB/Swiss-Prot
      A6NC86
      Related
      ENSP00000457369.1, ENST00000569031.6
      Conserved Domains (1) summary
      cl10471
      Location:38 → 88
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      43575509..43582098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438830.1 → XP_047294786.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform X1

    2. XM_011526971.3 → XP_011525273.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform X2

      See identical proteins and their annotated locations for XP_011525273.1

      UniProtKB/Swiss-Prot
      A6NC86
      Conserved Domains (1) summary
      cl10471
      Location:38 → 88
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46397139..46403730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321012.1 → XP_054176987.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform X1

    2. XM_054321013.1 → XP_054176988.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NC86.3 GenPept UniProtKB/Swiss-Prot:A6NC86

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