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    ZNF749 zinc finger protein 749 [ Homo sapiens (human) ]

    Gene ID: 388567, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF749provided by HGNC
    Official Full Name
    zinc finger protein 749provided by HGNC
    Primary source
    HGNC:HGNC:32783
    See related
    Ensembl:ENSG00000186230 AllianceGenome:HGNC:32783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF749 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57428565..57447101)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60522676..60544137)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57946693..57958469)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15138 Neighboring gene zinc finger protein 548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:57915187-57915686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15141 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:57923026-57923228 Neighboring gene zinc finger protein 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15143 Neighboring gene vomeronasal 1 receptor 1 Neighboring gene vomeronasal 1 receptor 107 pseudogene

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ16263, FLJ16360

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001023561.4NP_001018855.2  zinc finger protein 749 isoform 1

      See identical proteins and their annotated locations for NP_001018855.2

      Status: VALIDATED

      Source sequence(s)
      AC004076, AK122794, BP872084, DB099619
      Consensus CDS
      CCDS33132.2
      UniProtKB/Swiss-Prot
      O43361
      Related
      ENSP00000333980.4, ENST00000334181.5
      Conserved Domains (5) summary
      smart00349
      Location:862
      KRAB; krueppel associated box
      COG5048
      Location:295689
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1047
      KRAB; KRAB box
      pfam13465
      Location:599623
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001321952.2NP_001308881.1  zinc finger protein 749 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC004076, BP872084
      Conserved Domains (5) summary
      smart00349
      Location:155
      KRAB; krueppel associated box
      COG5048
      Location:288682
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:579599
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:340
      KRAB; KRAB box
      pfam13465
      Location:592616
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001321953.2NP_001308882.1  zinc finger protein 749 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC004076, BP872084
      UniProtKB/Swiss-Prot
      O43361
      Conserved Domains (3) summary
      COG5048
      Location:208602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:499519
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:512536
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001321954.2NP_001308883.1  zinc finger protein 749 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC004076, BP872084, DB099619
      UniProtKB/Swiss-Prot
      O43361
      Conserved Domains (3) summary
      COG5048
      Location:208602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:499519
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:512536
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57428565..57447101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526956.3XP_011525258.1  zinc finger protein 749 isoform X1

      See identical proteins and their annotated locations for XP_011525258.1

      Conserved Domains (5) summary
      smart00349
      Location:155
      KRAB; krueppel associated box
      COG5048
      Location:288682
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:579599
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:340
      KRAB; KRAB box
      pfam13465
      Location:592616
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      60522676..60544137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320972.1XP_054176947.1  zinc finger protein 749 isoform X2

    2. XM_054320973.1XP_054176948.1  zinc finger protein 749 isoform X1