MAS1 MAS1 proto-oncogene, G protein-coupled receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAS1provided by HGNC
Official Full Name: MAS1 proto-oncogene, G protein-coupled receptorprovided by HGNC
Primary source: HGNC:HGNC:6899
See related: Ensembl:ENSG00000130368 MIM:165180; AllianceGenome:HGNC:6899
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MAS; MGRA
Summary: This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]
Orthologs: mouse all
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Genomic context

Location:: 6q25.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (159888787..159917447)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (161134461..161165992)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (160312020..160338479)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myeloid-Mas Signaling Modulates Pathogenic Crosstalk among MYC[+]CD63[+] Endothelial Cells, MMP12[+] Macrophages, and Monocytes in Acetaminophen-Induced Liver Injury.
Title: Myeloid-Mas Signaling Modulates Pathogenic Crosstalk among MYC(+)CD63(+) Endothelial Cells, MMP12(+) Macrophages, and Monocytes in Acetaminophen-Induced Liver Injury.
Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1-7)/MasR signaling in normal and hypertensive pregnancy.
Title: Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1-7)/MasR signaling in normal and hypertensive pregnancy.
Mas receptor endocytosis and signaling in health and disease.
Title: Mas receptor endocytosis and signaling in health and disease.
Sex Difference in MasR Expression and Functions in the Renal System.
Title: Sex Difference in MasR Expression and Functions in the Renal System.
The function of the ACE2/Ang(1-7)/Mas receptor axis of the renin-angiotensin system in myocardial ischemia reperfusion injury.
Title: The function of the ACE2/Ang(1-7)/Mas receptor axis of the renin-angiotensin system in myocardial ischemia reperfusion injury.
Human placenta mesenchymal stem cell protection in ischemic stroke is angiotensin converting enzyme-2 and masR receptor-dependent.
Title: Human placenta mesenchymal stem cell protection in ischemic stroke is angiotensin converting enzyme-2 and masR receptor-dependent.
Neuroinflammation and COVID-19 Ischemic Stroke Recovery-Evolving Evidence for the Mediating Roles of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis and NLRP3 Inflammasome.
Title: Neuroinflammation and COVID-19 Ischemic Stroke Recovery-Evolving Evidence for the Mediating Roles of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis and NLRP3 Inflammasome.
Impact of angiotensin II type 1 and G-protein-coupled Mas receptor expression on the pulmonary performance of patients with idiopathic pulmonary fibrosis.
Title: Impact of angiotensin II type 1 and G-protein-coupled Mas receptor expression on the pulmonary performance of patients with idiopathic pulmonary fibrosis.
Localization of angiotensin-(1-7) and Mas receptor in the rat ovary throughout the estrous cycle.
Title: Localization of angiotensin-(1-7) and Mas receptor in the rat ovary throughout the estrous cycle.
Angiotensin- and angiotensin-(1-7) imbalance affects comorbidity of depression and coronary heart disease.
Title: Angiotensin-Ⅱ and angiotensin-(1-7) imbalance affects comorbidity of depression and coronary heart disease.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:481078

RH17660 (e-PCR)
- UniSTS:78654

HUEST-M13150 (e-PCR)
- UniSTS:78654

RH93491 (e-PCR)
- UniSTS:84053

GDB:181539 (e-PCR)
- UniSTS:155265

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables angiotensin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables angiotensin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables angiotensin type II receptor activity	TAS Traceable Author Statement more info	PubMed
enables peptide binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating angiotensin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in response to gonadotropin	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proto-oncogene Mas

Names: MAS1 oncogene; Mas-related G protein-coupled receptor A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001366704.2 → NP_001353633.1 proto-oncogene Mas

Status: REVIEWED

Source sequence(s)

AL035691

Consensus CDS

CCDS5272.1

UniProtKB/Swiss-Prot

E1P5B3, P04201, Q2TBC9, Q6FG47

UniProtKB/TrEMBL

W8W3P4

Related

ENSP00000252660.4, ENST00000252660.5

Conserved Domains (1) summary

cd15110
Location:33 → 307

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_002377.4 → NP_002368.1 proto-oncogene Mas

See identical proteins and their annotated locations for NP_002368.1

Status: REVIEWED

Source sequence(s)

AL035691, DB475311

Consensus CDS

CCDS5272.1

UniProtKB/Swiss-Prot

E1P5B3, P04201, Q2TBC9, Q6FG47

UniProtKB/TrEMBL

W8W3P4

Related

ENSP00000501180.2, ENST00000674077.2

Conserved Domains (1) summary

cd15110
Location:33 → 307

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors