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    MROH5 maestro heat like repeat family member 5 (gene/pseudogene) [ Homo sapiens (human) ]

    Gene ID: 389690, updated on 10-Dec-2024

    Summary

    Official Symbol
    MROH5provided by HGNC
    Official Full Name
    maestro heat like repeat family member 5 (gene/pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:42976
    See related
    Ensembl:ENSG00000226807 AllianceGenome:HGNC:42976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: suggests misassembly
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Biased expression in testis (RPKM 3.5) and heart (RPKM 0.2) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MROH5 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (141433825..141507229, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (142561183..142635781, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (142443925..142517329, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928037 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142385104-142385878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142385879-142386654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142386655-142387429 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142394223-142394840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142401193-142401813 Neighboring gene antisense transcript of PTP4A3, liver carcinoma survival associated Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142413010-142413773 Neighboring gene protein tyrosine phosphatase 4A3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:142417407-142417907 Neighboring gene VISTA enhancer hs1882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142441707-142442687 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142443451-142444139 Neighboring gene Putative chemokine-related protein FP248 Neighboring gene uncharacterized LOC105375789 Neighboring gene small nucleolar RNA SNORD5 Neighboring gene heterogeneous nuclear ribonucleoprotein A1pseudogene 38 Neighboring gene CEB42 minisatellite repeat instability region Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142501938-142502812 Neighboring gene uncharacterized LOC124902031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142517660-142518180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19593 Neighboring gene uncharacterized LOC105375791

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (5 hits/279 screens)

    EBI GWAS Catalog

    Description
    Genetics of coronary artery calcification among African Americans, a meta-analysis.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of FLJ43860 protein by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Clone Names

    • FLJ43860

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in cytoplasm  

    General protein information

    Preferred Names
    maestro heat-like repeat family member 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207414.3NP_997297.2  maestro heat-like repeat family member 5

      See identical proteins and their annotated locations for NP_997297.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, coding) differs at a polymorphic nucleotide compared to the reference genome sequence and represents the protein coding allele.
      Source sequence(s)
      ABBA01013690, AC100803, AC138647, KF459654, KF459918
      UniProtKB/Swiss-Prot
      Q6ZUA9

    RNA

    1. NR_102363.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two internal exons and uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC100803, AC138647, BC144560, KF459654, KF459918
      Related
      ENST00000521053.5
    2. NR_102364.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks four internal exons but it includes one additional exon, and it uses three alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC100803, AC138647, BC144560, KF459654, KF459918
      Related
      ENST00000523857.5
    3. NR_160399.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, non-coding) contains a polymorphic nt that creates an early termination codon compared to variant 1, coding. The resulting transcript is considered to be non-protein coding since it is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC100803, AC138647, KF459654, KF459918
      Related
      ENST00000430863.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      141433825..141507229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791786.1 Reference GRCh38.p14 PATCHES

      Range
      100379..173783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187574.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      106281..123607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      142561183..142635781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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