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    HPGDS hematopoietic prostaglandin D synthase [ Homo sapiens (human) ]

    Gene ID: 27306, updated on 10-Dec-2024

    Summary

    Official Symbol
    HPGDSprovided by HGNC
    Official Full Name
    hematopoietic prostaglandin D synthaseprovided by HGNC
    Primary source
    HGNC:HGNC:17890
    See related
    Ensembl:ENSG00000163106 MIM:602598; AllianceGenome:HGNC:17890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GSTS; PGD2; PGDS; GSTS1; GSTS1-1
    Summary
    Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 12.7), lung (RPKM 6.6) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HPGDS in Genome Data Viewer
    Location:
    4q22.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (94298535..94342836, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (97614053..97658342, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (95219686..95263987, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SMARCAD1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21729 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:95129093-95129596 Neighboring gene high mobility group box 3 pseudogene 15 Neighboring gene SNF2 related chromatin remodeling ATPase with DExD box 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:95303965-95304818 Neighboring gene NANOG hESC enhancer GRCh37_chr4:95305750-95306251 Neighboring gene ribosomal protein L35a pseudogene 11 Neighboring gene Sharpr-MPRA regulatory region 14184 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:95361510-95361672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15575 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:95417748-95417936 Neighboring gene PDZ and LIM domain 5 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:95455489-95456413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:95456414-95457337

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables prostaglandin-D synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in locomotory behavior TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of male germ cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prostaglandin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prostaglandin metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to nematode IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to selenium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    hematopoietic prostaglandin D synthase
    Names
    GST class-sigma
    epididymis secretory sperm binding protein
    glutathione S-transferase sigma
    glutathione-dependent PGD synthase
    glutathione-dependent PGD synthetase
    glutathione-requiring prostaglandin D synthase
    hematopoietic prostaglandin D2 synthase
    prostaglandin-H2 D-isomerase
    NP_055300.1
    XP_005262989.1
    XP_054205671.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032150.1 RefSeqGene

      Range
      5041..49342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_014485.3NP_055300.1  hematopoietic prostaglandin D synthase

      See identical proteins and their annotated locations for NP_055300.1

      Status: REVIEWED

      Source sequence(s)
      AC096746, BC020734
      Consensus CDS
      CCDS3640.1
      UniProtKB/Swiss-Prot
      O60760, Q6FHT9
      UniProtKB/TrEMBL
      A0A384P5J0
      Related
      ENSP00000295256.5, ENST00000295256.10
      Conserved Domains (2) summary
      cd10295
      Location:82181
      GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases
      cd03039
      Location:473
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      94298535..94342836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262932.4XP_005262989.1  hematopoietic prostaglandin D synthase isoform X1

      Conserved Domains (3) summary
      PTZ00057
      Location:3166
      PTZ00057; glutathione s-transferase; Provisional
      cd10295
      Location:51150
      GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases
      cd03039
      Location:443
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      97614053..97658342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349696.1XP_054205671.1  hematopoietic prostaglandin D synthase isoform X1