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    Pycr3 pyrroline-5-carboxylate reductase 3 [ Mus musculus (house mouse) ]

    Gene ID: 66194, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pycr3provided by MGI
    Official Full Name
    pyrroline-5-carboxylate reductase 3provided by MGI
    Primary source
    MGI:MGI:1913444
    See related
    Ensembl:ENSMUSG00000022571 AllianceGenome:MGI:1913444
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pycrl; 1110058B13Rik; 2700073G24Rik
    Summary
    Predicted to enable cytidine deaminase activity and pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Predicted to act upstream of or within cytidine deamination. Predicted to be located in cytosol; intercellular bridge; and mitotic spindle. Orthologous to human PYCR3 (pyrroline-5-carboxylate reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 50.1), duodenum adult (RPKM 48.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pycr3 in Genome Data Viewer
    Location:
    15 D3; 15 35.09 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75788319..75793369, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75916463..75921560, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 delta Neighboring gene tigger transposable element derived 5 Neighboring gene GDP-L-fucose synthase Neighboring gene zinc finger protein 623

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    2. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    5. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytidine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-proline biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-proline biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cytidine deamination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pyrroline-5-carboxylate reductase 3
    Names
    P5C reductase 3
    P5CR 3
    pyrroline-5-carboxylate reductase-like protein
    NP_079688.2
    XP_006521315.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025412.3 → NP_079688.2  pyrroline-5-carboxylate reductase 3

      See identical proteins and their annotated locations for NP_079688.2

      Status: VALIDATED

      Source sequence(s)
      AC116520
      Consensus CDS
      CCDS37109.1
      UniProtKB/Swiss-Prot
      Q8R0P9, Q9D0X2, Q9DCC4
      Related
      ENSMUSP00000049605.8, ENSMUST00000053918.9
      Conserved Domains (3) summary
      PLN02688
      Location:10 → 273
      PLN02688; pyrroline-5-carboxylate reductase
      pfam03807
      Location:12 → 104
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
      pfam14748
      Location:166 → 270
      P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      75788319..75793369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521252.4 → XP_006521315.1  pyrroline-5-carboxylate reductase 3 isoform X1

      Conserved Domains (1) summary
      TIGR00112
      Location:1 → 161
      proC; pyrroline-5-carboxylate reductase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCC4.2 GenPept UniProtKB/Swiss-Prot:Q9DCC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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