Esr1 estrogen receptor 1 (alpha) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Esr1provided by MGI
Official Full Name: estrogen receptor 1 (alpha)provided by MGI
Primary source: MGI:MGI:1352467
See related: Ensembl:ENSMUSG00000019768 AllianceGenome:MGI:1352467
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ER; ERa; ESR; Estr; Estra; Nr3a1; ERalpha; ER-alpha
Summary: This gene encodes an estrogen receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression: Biased expression in ovary adult (RPKM 13.9), subcutaneous fat pad adult (RPKM 12.1) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A1; 10 2.03 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (4561989..4955633)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (4611989..5005633)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of the p-Estrogen Receptor at Serine on Its Function and Breast Growth.
Title: Effect of the p-Estrogen Receptor at Serine on Its Function and Breast Growth.
Transcription repression of estrogen receptor alpha by ghrelin/Gq/11/YAP signaling in granulosa cells promotes polycystic ovary syndrome.
Title: Transcription repression of estrogen receptor alpha by ghrelin/Gq/11/YAP signaling in granulosa cells promotes polycystic ovary syndrome.
Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice.
Title: Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice.
Estrogen receptor-alpha signaling in tanycytes lies at the crossroads of fertility and metabolism.
Title: Estrogen receptor-α signaling in tanycytes lies at the crossroads of fertility and metabolism.
Knockdown of Esr1 from DRD1-Rich Brain Regions Affects Adipose Tissue Metabolism: Potential Crosstalk between Nucleus Accumbens and Adipose Tissue.
Title: Knockdown of Esr1 from DRD1-Rich Brain Regions Affects Adipose Tissue Metabolism: Potential Crosstalk between Nucleus Accumbens and Adipose Tissue.
An estrogen receptor alpha-derived peptide improves glucose homeostasis during obesity.
Title: An estrogen receptor α-derived peptide improves glucose homeostasis during obesity.
Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor alpha.
Title: Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor α.
Sex-specific regulation of miR-22 and ERalpha in white adipose tissue of obese dam's female offspring impairs the early postnatal development of functional beige adipocytes in mice.
Title: Sex-specific regulation of miR-22 and ERα in white adipose tissue of obese dam's female offspring impairs the early postnatal development of functional beige adipocytes in mice.
Linking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse model.
Title: Linking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse model.
Increased palmitoylation improves estrogen receptor alpha-dependent hippocampal synaptic deficits in a mouse model of synucleinopathy.
Title: Increased palmitoylation improves estrogen receptor alpha-dependent hippocampal synaptic deficits in a mouse model of synucleinopathy.

Submit: New GeneRIF Correction See all GeneRIFs (683)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (15) 1 citation
Targeted (38) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Esr1 (e-PCR), detects polymorphism
- UniSTS:506887

NoName (e-PCR)
- UniSTS:236299

AU018232 (e-PCR)
- UniSTS:208488

Esr1 (e-PCR), detects polymorphism
- UniSTS:256888

PMC25853P1 (e-PCR)
- UniSTS:272290

RH124384 (e-PCR)
- UniSTS:161206

Esr1 (e-PCR), detects polymorphism
- UniSTS:143041

Esr1 (e-PCR), detects polymorphism
- UniSTS:257222

Esr1 (e-PCR), detects polymorphism
- UniSTS:257223

Esr1 (e-PCR), detects polymorphism
- UniSTS:275685

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IEA Inferred from Electronic Annotation more info
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables G protein-coupled estrogen receptor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables TBP-class protein binding	IEA Inferred from Electronic Annotation more info
enables TBP-class protein binding	ISO Inferred from Sequence Orthology more info
enables TFIIB-class transcription factor binding	IEA Inferred from Electronic Annotation more info
enables TFIIB-class transcription factor binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables estrogen response element binding	IEA Inferred from Electronic Annotation more info
enables estrogen response element binding	ISO Inferred from Sequence Orthology more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear steroid receptor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables steroid binding	ISO Inferred from Sequence Orthology more info
enables steroid binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables type 1 metabotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
involved_in Sertoli cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within androgen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within antral ovarian follicle growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to estradiol stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to estradiol stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to estradiol stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to estrogen stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to estrogen stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in estrogen receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland branching involved in pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic nuclear division	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nuclear receptor-mediated steroid hormone signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nuclear receptor-mediated steroid hormone signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric-oxide synthase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prostate epithelial cord elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to chromatin	IEA Inferred from Electronic Annotation more info
involved_in protein localization to chromatin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in stem cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in steroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within uterus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vagina development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in euchromatin	IEA Inferred from Electronic Annotation more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: estrogen receptor

Names: C-terminally-truncated estrogen receptor alpha product-4; C-terminally-truncated estrogen receptor alpha product-5; C-terminally-truncated estrogen receptor alpha product-6; C-terminally-truncated estrogen receptor alpha product-7; estradiol receptor; nuclear receptor subfamily 3 group A member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302531.2 → NP_001289460.1 estrogen receptor isoform 1

See identical proteins and their annotated locations for NP_001289460.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 6 all encode the same isoform (1).

Source sequence(s)

AC153573, AC156393

Consensus CDS

CCDS56678.1

UniProtKB/Swiss-Prot

P19785, Q9JJT5, Q9QY51, Q9QY52

UniProtKB/TrEMBL

B3VQI7, E7FJU2

Related

ENSMUSP00000101214.2, ENSMUST00000105589.2

Conserved Domains (4) summary

cd06949
Location:314 → 551

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:184 → 265

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 185

Oest_recep; Oestrogen receptor

pfam12743
Location:556 → 599

ESR1_C; Oestrogen-type nuclear receptor final C-terminal
NM_001302532.2 → NP_001289461.1 estrogen receptor isoform 1

See identical proteins and their annotated locations for NP_001289461.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 6 all encode the same isoform (1).

Source sequence(s)

AC153573, AC156393, AC158617

Consensus CDS

CCDS56678.1

UniProtKB/Swiss-Prot

P19785, Q9JJT5, Q9QY51, Q9QY52

UniProtKB/TrEMBL

B3VQI7, E7FJU2

Related

ENSMUSP00000101215.2, ENSMUST00000105590.8

Conserved Domains (4) summary

cd06949
Location:314 → 551

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:184 → 265

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 185

Oest_recep; Oestrogen receptor

pfam12743
Location:556 → 599

ESR1_C; Oestrogen-type nuclear receptor final C-terminal
NM_001302533.2 → NP_001289462.1 estrogen receptor isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, contains an alternate exon in the 3' coding region and uses an upstream alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC153573, AC156393

UniProtKB/TrEMBL

D3Z6V3

Related

ENSMUSP00000101213.2, ENSMUST00000105588.8

Conserved Domains (3) summary

cd07171
Location:184 → 265

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 185

Oest_recep; Oestrogen receptor

cl11397
Location:314 → 416

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001428459.1 → NP_001415388.1 estrogen receptor isoform 1

Status: REVIEWED

Source sequence(s)

AC153573, AC156393, AC158617

UniProtKB/Swiss-Prot

P19785, Q9JJT5, Q9QY51, Q9QY52

UniProtKB/TrEMBL

B3VQI7, E7FJU2
NM_007956.6 → NP_031982.1 estrogen receptor isoform 1

See identical proteins and their annotated locations for NP_031982.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, 3, and 6 all encode the same isoform (1).

Source sequence(s)

AC153573, AC156393, AC158617

Consensus CDS

CCDS56678.1

UniProtKB/Swiss-Prot

P19785, Q9JJT5, Q9QY51, Q9QY52

UniProtKB/TrEMBL

B3VQI7, E7FJU2

Related

ENSMUSP00000070070.8, ENSMUST00000067086.14

Conserved Domains (4) summary

cd06949
Location:314 → 551

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:184 → 265

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 185

Oest_recep; Oestrogen receptor

pfam12743
Location:556 → 599

ESR1_C; Oestrogen-type nuclear receptor final C-terminal

RNA

NR_126357.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains an alternate exon in the 5' region, contains an alternate internal exon and uses an upstream alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC153573, AC158617, AC158639

Related

ENSMUST00000149195.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

4561989..4955633

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243066.4 → XP_011241368.1 estrogen receptor isoform X1

See identical proteins and their annotated locations for XP_011241368.1

UniProtKB/Swiss-Prot

P19785, Q9JJT5, Q9QY51, Q9QY52

UniProtKB/TrEMBL

B3VQI7, E7FJU2

Conserved Domains (4) summary

cd06949
Location:314 → 551

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:184 → 265

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 185

Oest_recep; Oestrogen receptor

pfam12743
Location:556 → 599

ESR1_C; Oestrogen-type nuclear receptor final C-terminal
XM_011243068.4 → XP_011241370.1 estrogen receptor isoform X1

See identical proteins and their annotated locations for XP_011241370.1

UniProtKB/Swiss-Prot

P19785, Q9JJT5, Q9QY51, Q9QY52

UniProtKB/TrEMBL

B3VQI7, E7FJU2

Conserved Domains (4) summary

cd06949
Location:314 → 551

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:184 → 265

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 185

Oest_recep; Oestrogen receptor

pfam12743
Location:556 → 599

ESR1_C; Oestrogen-type nuclear receptor final C-terminal
XM_006512435.3 → XP_006512498.1 estrogen receptor isoform X1

See identical proteins and their annotated locations for XP_006512498.1

UniProtKB/Swiss-Prot

P19785, Q9JJT5, Q9QY51, Q9QY52

UniProtKB/TrEMBL

B3VQI7, E7FJU2

Conserved Domains (4) summary

cd06949
Location:314 → 551

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:184 → 265

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 185

Oest_recep; Oestrogen receptor

pfam12743
Location:556 → 599

ESR1_C; Oestrogen-type nuclear receptor final C-terminal
XM_006512434.5 → XP_006512497.1 estrogen receptor isoform X1

See identical proteins and their annotated locations for XP_006512497.1

UniProtKB/Swiss-Prot

P19785, Q9JJT5, Q9QY51, Q9QY52

UniProtKB/TrEMBL

B3VQI7, E7FJU2

Conserved Domains (4) summary

cd06949
Location:314 → 551

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:184 → 265

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 185

Oest_recep; Oestrogen receptor

pfam12743
Location:556 → 599

ESR1_C; Oestrogen-type nuclear receptor final C-terminal
XM_036155590.1 → XP_036011483.1 estrogen receptor isoform X2

UniProtKB/TrEMBL

A0A1W7GYW9, A0A1W7GYY4

Conserved Domains (3) summary

cd07171
Location:184 → 265

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 185

Oest_recep; Oestrogen receptor

cl11397
Location:314 → 370

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
XM_006512433.5 → XP_006512496.1 estrogen receptor isoform X1

See identical proteins and their annotated locations for XP_006512496.1

UniProtKB/Swiss-Prot

P19785, Q9JJT5, Q9QY51, Q9QY52

UniProtKB/TrEMBL

B3VQI7, E7FJU2

Conserved Domains (4) summary

cd06949
Location:314 → 551

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:184 → 265

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 185

Oest_recep; Oestrogen receptor

pfam12743
Location:556 → 599

ESR1_C; Oestrogen-type nuclear receptor final C-terminal